公开(公告)号：US4563442A

公开(公告)日：1986-01-07

申请号：US653259

申请日：1984-09-24

申请人： Gladys M. Clem ,  LaVerne D. Boeck ,  Marie T. Anderson ,  Karl H. Michel

发明人： Gladys M. Clem ,  LaVerne D. Boeck ,  Marie T. Anderson ,  Karl H. Michel

IPC分类号： C07G11/00 ,  A23K20/195 ,  A61K38/00 ,  A61P31/04 ,  C07K9/00 ,  C07K14/195 ,  C07K14/41 ,  C12P19/60 ,  C12P21/04 ,  C12R1/045 ,  A61K37/00 ,  A61K35/00

CPC分类号： C12R1/045 ,  A23K20/195 ,  C07K9/008 ,  Y10S930/19 ,  Y10S930/27

摘要： New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B.sub.1, B.sub.2, B.sub.3, C.sub.1, C.sub.2, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N, O and actaplanin .psi.aglycone, and salts thereof, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.

摘要翻译： 新型糖肽抗生素，其结构式如下：其中W是选自actaplanin因子B1，B2，B3，C1，C2，C3，D1，D2，E1，G，K，L，M的糖肽抗生素的剩余部分， N，O和actaplanin psi糖苷配基及其盐，特别是其药学上可接受的盐是有用的新型抗生素对革兰氏阳性细菌具有活性，并增加饲料效率的利用并提高反刍动物中的牛奶生产。

公开(公告)号：US4663282A

公开(公告)日：1987-05-05

申请号：US729785

申请日：1985-05-02

申请人： LaVerne D. Boeck ,  Gladys M. Clem ,  Charles L. Hershberger ,  Marie T. Anderson ,  Karl H. Michel

发明人： LaVerne D. Boeck ,  Gladys M. Clem ,  Charles L. Hershberger ,  Marie T. Anderson ,  Karl H. Michel

IPC分类号： A23K20/195 ,  C07K9/00 ,  C12P21/00 ,  C12N1/20 ,  C12P21/02 ,  C12R1/045

CPC分类号： C12R1/045 ,  A23K20/195 ,  C07K9/008 ,  Y10S435/827

摘要： New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.

摘要翻译： 新型糖肽抗生素CUC / CSV，其具有下式：其中R为L-赖氨酰胺基; R1是二糖甘露糖基 - 葡糖基; R2和R3是甘露糖基，其盐，特别是药学上可接受的盐是有用的，新的抗生素对革兰氏阳性细菌具有活性，并增加了饲料效率的利用，提高了反刍动物的产奶量。

公开(公告)号：US4537715A

公开(公告)日：1985-08-27

申请号：US544338

申请日：1983-10-21

申请人： LaVerne D. Boeck ,  Gladys M. Clem ,  Charles L. Hershberger ,  Marie T. Anderson ,  Karl H. Michel

发明人： LaVerne D. Boeck ,  Gladys M. Clem ,  Charles L. Hershberger ,  Marie T. Anderson ,  Karl H. Michel

IPC分类号： A23K20/195 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/04 ,  C07H17/00 ,  C07K9/00 ,  C12P19/62 ,  C12P21/04 ,  C12R1/045 ,  C07C103/52 ,  A23K1/22

CPC分类号： C12R1/045 ,  A23K20/195 ,  C07K9/008 ,  Y10S930/19 ,  Y10S930/27

摘要： New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.

公开(公告)号：US5496931A

公开(公告)日：1996-03-05

申请号：US406760

申请日：1995-03-17

申请人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

发明人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

IPC分类号： A01N43/22 ,  A01N43/90 ,  C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62 ,  C12R1/01 ,  A01N27/00

CPC分类号： C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62 ,  Y10S435/822

摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.

摘要翻译： 包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。

公开(公告)号：US5571901A

公开(公告)日：1996-11-05

申请号：US479500

申请日：1995-06-07

申请人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

发明人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

IPC分类号： A01N43/22 ,  A01N43/90 ,  C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62 ,  C12R1/01 ,  C07H7/06

CPC分类号： C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62 ,  Y10S435/822

摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.

摘要翻译： 包含主要成分A83543A和A83543D以及次要成分A83543B，A83543C，A83543E，A83543F，A83543G，A83543H和A83543J的发酵产品A83543由新描述的种类，酿酒酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫，杀螨或外寄生疫苗组合，组合物和方法。

公开(公告)号：US5362634A

公开(公告)日：1994-11-08

申请号：US773754

申请日：1991-10-10

申请人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

发明人： LaVerne D. Boeck ,  Hang Chio ,  Tom E. Eaton ,  Otis W. Godfrey, Jr. ,  Karl H. Michel ,  Walter M. Nakatsukasa ,  Raymond C. Yao

IPC分类号： C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62

CPC分类号： C07H17/08 ,  C12N1/20 ,  C12P1/06 ,  C12P19/62 ,  Y10S435/822

摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.

摘要翻译： 包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。

公开(公告)号：US5286631A

公开(公告)日：1994-02-15

申请号：US663194

申请日：1991-02-28

申请人： LaVerne D. Boeck ,  Otis W. Godfrey, Jr. ,  Karl H. Michel

发明人： LaVerne D. Boeck ,  Otis W. Godfrey, Jr. ,  Karl H. Michel

IPC分类号： A61K20060101 ,  C07K20060101 ,  C12N1/20 ,  C12P1/06 ,  C12P19/54 ,  C12P21/04

CPC分类号： C12P1/06 ,  Y10S435/822 ,  Y10S435/886

摘要： Newly-discovered antibiotic A10255 factors B, C, E, and F are produced by submerged aerobic fermentation of previously-unknown Streptomyces gardneri strain NRRL 15922, or an A10255-producing variant, mutant or recombinant thereof. The antibiotics are active against a wide variety of pathogenic bacteria, and also enhance feed-utilization efficiency in chickens, weanling pigs and cattle.

摘要翻译： 新发现的抗生素A10255因子B，C，E和F通过先前未知的前列腺链球菌菌株NRRL 15922或其产生A10255的突变体或重组体的潜在需氧发酵产生。 抗生素对各种致病菌具有活性，并且还提高了鸡，断奶仔猪和牛的饲料利用效率。

公开(公告)号：US4537777A

公开(公告)日：1985-08-27

申请号：US562256

申请日：1983-12-16

申请人： Marie T. Anderson ,  Karl H. Michel ,  Thomas H. Sands

发明人： Marie T. Anderson ,  Karl H. Michel ,  Thomas H. Sands

IPC分类号： C07G11/00 ,  A61K35/74 ,  A61K36/06 ,  A61P35/00 ,  C12P1/02 ,  C12P7/40 ,  C12P13/00 ,  C12R1/645 ,  A01N37/34 ,  C07C119/02

CPC分类号： C12P13/002 ,  C12R1/645

摘要： New A52688 factors A, C, D, E, F, G, H, J and K which have the common general formula: ##STR1## are antibacterial and antineoplastic agents. Methods of preparing the antibiotics by culturing a strain of Mycoleptodiscus terrestris are provided.

摘要翻译： 新的A52688因子A，C，D，E，F，G，H，J和K具有以下通用的通式：是抗细菌和抗肿瘤药物。 提供了通过培养Mycoleptodiscus terrestris菌株制备抗生素的方法。

公开(公告)号：US4492650A

公开(公告)日：1985-01-08

申请号：US423948

申请日：1982-09-27

申请人： Karl H. Michel ,  Ralph E. Kastner

发明人： Karl H. Michel ,  Ralph E. Kastner

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07C103/52

CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S930/19 ,  Y10S930/27

摘要： Antibiotic A54556, a complex of 8 individual factors, produced by submerged, aerobic fermentation of new Streptomyces hawaiiensis NRRL 15010. The complex and the individual, separated factors are active against Staphylococcus and Streptococcus which are penicillin resistant.

摘要翻译： 抗生素A54556是8种独立因子的复合物，通过新型链霉菌（Streptomyces hawaiiensis）NRRL 15010的浸没式好氧发酵产生。复合物和个体分离因子对青霉素抗性的葡萄球菌和链球菌具有活性。

公开(公告)号：US4400510A

公开(公告)日：1983-08-23

申请号：US304293

申请日：1981-09-21

申请人： Karl H. Michel ,  Marvin M. Hoehn

发明人： Karl H. Michel ,  Marvin M. Hoehn

IPC分类号： C07D241/46 ,  C12P17/12

CPC分类号： C07D241/46 ,  C12P17/12

摘要： Antibiotic A-32256 which is produced by submerged, aerobic fermentation of a Streptomyces sp. NRRL 12067. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus and various anaerobic species. In addition, the antibiotic has shown antitrichomonas activity in vitro, as well as activity for improving ruminant feed efficency and as a mosquito larvacide.

摘要翻译： 抗生素A-32256，其通过链霉菌（Streptomyces sp。）的潜在，好氧发酵产生。 NRRL 12067.抗生素对葡萄球菌和链球菌及各种厌氧物质具有抗菌活性。 此外，抗生素在体外已经显示出抗滴虫活性，以及​​提高反刍动物饲料效率的活性和作为灭蚊剂。