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60 条记录 (耗时 0.022 秒)

    Optical phase measurement of target
    1.
    发明申请
    Optical phase measurement of target 有权
    目标光学相位测量

    公开(公告)号：US20050194523A1

    公开(公告)日：2005-09-08

    申请号：US10795917

    申请日：2004-03-08

    申请人： Gregory VanWiggeren ,  Daniel Roitman

    发明人： Gregory VanWiggeren ,  Daniel Roitman

    IPC分类号： G01N21/21 ,  G01J9/00 ,  G01N21/27 ,  G01N21/39 ,  G01N21/55 ,  G02B6/00

    CPC分类号： G01J9/00 ,  G01N21/553

    摘要： Optical phase detection includes generating a first lightwave having a first polarization and a second lightwave having a polarization that is offset from the first polarization, and imposing a relative delay between the first and second lightwaves. The relative delay causes a frequency offset between the lightwaves as wavelength is tuned over a designated wavelength range. Directing the first and second lightwaves to a target provides a third lightwave and a fourth lightwave. A polarization component of the third lightwave and a polarization component of the fourth lightwave are detected to provide a detected signal at the frequency offset. The optical phase detection then includes extracting a phase difference, induced by the target, between the polarization components of the third and the fourth lightwaves.

    摘要翻译： 光相位检测包括产生具有第一偏振的第一光波和具有偏离第一偏振的偏振的第二光波，并且在第一和第二光波之间施加相对延迟。 当波长在指定的波长范围内调谐时，相对延迟会导致光波之间的频率偏移。 将第一和第二光波导向目标提供第三光波和第四光波。 检测第三光波的偏振分量和第四光波的偏振分量，以提供频偏处的检测信号。 然后，光学相位检测包括在第三和第四光波的偏振分量之间提取由目标感应的相位差。

    Light-sensing system that uses light guides
    2.
    发明申请
    Light-sensing system that uses light guides 审中-公开
    使用光导的感光系统

    公开(公告)号：US20060227328A1

    公开(公告)日：2006-10-12

    申请号：US11101848

    申请日：2005-04-08

    申请人： Gregory Vanwiggeren ,  Rene Helbing ,  Daniel Roitman

    发明人： Gregory Vanwiggeren ,  Rene Helbing ,  Daniel Roitman

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553

    摘要： Light-sensing systems and methods thereof are described. A light source illuminates target areas arrayed on a surface. Light guides receive light reflected from the target areas. The amount of light reflected from a target area corresponds at least in part to the composition of a substance associated with that target area. Detectors receive reflected light carried by the light guides.

    摘要翻译： 描述了光感测系统及其方法。 光源照亮阵列在表面上的目标区域。 导光板接收从目标区域反射的光。 从目标区域反射的光的量至少部分地对应于与该目标区域相关联的物质的组成。 检测器接收光导所携带的反射光。

    Sample holder for surface plasmon resonance measuring instruments
    4.
    发明申请
    Sample holder for surface plasmon resonance measuring instruments 有权
    表面等离子体共振测量仪器的样品架

    公开(公告)号：US20060269453A1

    公开(公告)日：2006-11-30

    申请号：US11141167

    申请日：2005-05-31

    申请人： Daniel Roitman ,  Gregory VanWiggeren

    发明人： Daniel Roitman ,  Gregory VanWiggeren

    IPC分类号： B01L3/00

    CPC分类号： G01N21/553 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/0822 ,  B01L2300/161 ,  B82Y20/00 ,  G02B5/008 ,  Y10T436/24 ,  Y10T436/25

    摘要： A droplet sample holder, especially a sample holder for use in a measuring instrument utilizing surface plasmon resonance. The sample holder reduces or minimizes the measurement distortion result of the droplet “pherpheral concentration effect” by surrounding the analysis zone with a wettable (hydrophilic) zone that captures the periphery of the droplet to keep the pheriphery of the droplet and the increased concentration of the analyte out of the analysis zone. The wettable zone is surrounded by a nonwettable (hydrophobic) zone that restricts the periphery of the droplet to analysis zone and the wettable zone.

    摘要翻译： 液滴样品架，特别是用于使用表面等离子体共振的测量仪器中的样品架。 样品架通过用可捕获液滴的周边的可湿性（亲水性）区围绕分析区来降低或最小化液滴“pherpheral浓度效应”的测量失真结果，以保持液滴的浓度，并且增加浓度 分析出分析区。 可湿润区域被不可润湿（疏水）区域围绕，该区域将液滴的周边限制到分析区域和可湿性区域。

    Wavelength-tuned intensity measurement of surface plasmon resonance sensor
    5.
    发明申请
    Wavelength-tuned intensity measurement of surface plasmon resonance sensor 审中-公开
    表面等离子体共振传感器的波长调谐强度测量

    公开(公告)号：US20050244093A1

    公开(公告)日：2005-11-03

    申请号：US10838790

    申请日：2004-05-03

    申请人： Gregory VanWiggeren ,  Daniel Roitman

    发明人： Gregory VanWiggeren ,  Daniel Roitman

    IPC分类号： G01N21/27 ,  G01N21/39 ,  G01N21/55 ,  G02B6/00

    CPC分类号： G01N21/553

    摘要： An incident signal illuminates an SPR sensor over a wavelength range. Intensity of a reflected signal from the SPR sensor is detected with wavelength discrimination imposed on the incident signal or the reflected signal. The wavelength discrimination is imposed at a predesignated tuning rate within the wavelength range. The detected intensity is then sampled at a sampling rate and an intensity profile associated with the SPR sensor is established from the sampling with a wavelength resolution determined by the tuning rate and the sampling rate.

    摘要翻译： 入射信号在波长范围内照亮SPR传感器。 通过施加在入射信号或反射信号上的波长鉴别来检测来自SPR传感器的反射信号的强度。 在波长范围内以预定的调谐速率施加波长鉴别。 然后以采样率对检测到的强度进行采样，并从采用由调谐率和采样率确定的波长分辨率的采样建立与SPR传感器相关联的强度分布。

    Evanescent wave sensor with attached ligand
    9.
    发明申请
    Evanescent wave sensor with attached ligand 审中-公开
    具有附着配体的渐逝波传感器

    公开(公告)号：US20070099180A1

    公开(公告)日：2007-05-03

    申请号：US11264808

    申请日：2005-10-31

    申请人： Karla Robotti ,  Daniel Roitman

    发明人： Karla Robotti ,  Daniel Roitman

    IPC分类号： C12Q1/70 ,  G01N33/554 ,  C12M1/34

    CPC分类号： G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553 ,  G01N33/54353

    摘要： The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a β-hydroxy-linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacting a first reactive moiety which has an epoxy-ring moiety with a second reactive moiety which has an amino moiety or a thiol moiety, as further described herein. Also provided by the invention are methods in which a subject evanescent wave sensor is contacted with a sample, and binding of analytes in the sample to the sensor is assessed by evanescent wave detection. The invention also provides kits and systems for performing the subject methods.

    摘要翻译： 本发明在具体实施方案中提供了一种ev逝波传感器，其包括通过本文定义的β-羟基 - 连接体部分与传感器底物结合的配体。 还提供了制备对象ev逝波传感器的方法，其包括使具有环氧环部分的第一反应性部分与具有氨基部分或硫醇部分的第二反应性部分接触，如本文进一步描述的。 本发明还提供了一种方法，其中对象ev逝波传感器与样品接触，并且通过ev逝波检测来评估样品中的分析物与传感器的结合。 本发明还提供用于执行主题方法的套件和系统。

    Integrated opto-electric SPR sensor
    10.
    发明申请
    Integrated opto-electric SPR sensor 审中-公开
    集成光电SPR传感器

    公开(公告)号：US20070052049A1

    公开(公告)日：2007-03-08

    申请号：US11222206

    申请日：2005-09-07

    申请人： Sandeep Bahl ,  Daniel Roitman

    发明人： Sandeep Bahl ,  Daniel Roitman

    IPC分类号： H01L27/14

    CPC分类号： G01N21/553 ,  G01N21/253

    摘要： An integrated opto-electric sensor includes a wavenumber matching structure that is integrated onto a silicon substrate, and a first conductive electrode that is adjacent to one of a lightly doped and an undoped region in the silicon substrate to form a Schottky junction. A dielectric is positioned adjacent to the first conductive electrode, and a second conductive electrode is formed at the silicon substrate. The first conductive electrode and the second conductive electrode provide coupling for a detected signal that is provided in response to illumination of the wavenumber matching structure by an optical signal.

    摘要翻译： 集成光电传感器包括集成在硅衬底上的波数匹配结构和与硅衬底中的轻掺杂区域和未掺杂区域中的一个相邻的第一导电电极，以形成肖特基结。 电介质位于与第一导电电极相邻的位置处，在硅衬底上形成第二导电电极。 第一导电电极和第二导电电极为通过光信号响应于波数匹配结构的照明而提供的检测信号提供耦合。