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公开(公告)号：US20110070312A1
公开(公告)日：2011-03-24
申请号：US12849054
申请日：2010-08-03
申请人： Guobao Wei , Lawrence A. Shimp , Sheldon W. Dean, III , Mark DeCaro , Carl R. Schwarz , Martin O. Ouko , Keyvan Behnam
发明人： Guobao Wei , Lawrence A. Shimp , Sheldon W. Dean, III , Mark DeCaro , Carl R. Schwarz , Martin O. Ouko , Keyvan Behnam
CPC分类号： A61L27/3608 , A61L27/3691 , A61L2430/02 , A61L2430/40
摘要： Methods for demineralizing bone are provided. In some embodiments, the methods include demineralizing the bone in a demineralization medium and separating the bone into particles during demineralization. In other embodiments, the methods include placing the bone in a demineralization medium and treating the demineralization medium while the bone is in the demineralization medium to optimize the demineralization process.
摘要翻译： 提供了使骨质脱矿质的方法。 在一些实施方案中，所述方法包括在脱矿质介质中使骨骼脱矿质，并在脱矿质过程中将骨分离成颗粒。 在其他实施方案中，所述方法包括将骨放置在脱盐培养基中并在骨在脱盐培养基中处理脱矿质培养基以优化脱矿质过程。
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公开(公告)号：US08357384B2
公开(公告)日：2013-01-22
申请号：US12140044
申请日：2008-06-16
申请人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
发明人： Keyvan Behnam , Guobao Wei , Nanette Forsyth , Todd M. Boyce , Lawrence A. Shimp
CPC分类号： A61K35/00 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3695 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。 在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理部分去矿物质的骨以破坏骨的胶原结构，以及任选地提供组织衍生的提取物，并将组织衍生的提取物加入到部分去矿物质 骨。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。
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公开(公告)号：US20090157087A1
公开(公告)日：2009-06-18
申请号：US12205539
申请日：2008-09-05
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US08722075B2
公开(公告)日：2014-05-13
申请号：US12605746
申请日：2009-10-26
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译： 提供了促进骨形成的方法。 更具体地，提供了促进破骨细胞形成促进骨形成的方法。 在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。
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公开(公告)号：US20100239634A1
公开(公告)日：2010-09-23
申请号：US12605746
申请日：2009-10-26
IPC分类号： A61F2/28 , A61K35/32 , A61K33/42 , A61K38/19 , A61K38/48 , A61K38/29 , A61P19/08 , A61K38/18 , A61K31/573 , A61K31/593 , A61K31/5575 , A61K38/20 , A61P19/00
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译： 提供了促进骨形成的方法。 更具体地，提供了促进破骨细胞形成促进骨形成的方法。 在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。
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公开(公告)号：US09333082B2
公开(公告)日：2016-05-10
申请号：US12205539
申请日：2008-09-05
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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公开(公告)号：US08642061B2
公开(公告)日：2014-02-04
申请号：US12140062
申请日：2008-06-16
申请人： Lawrence A. Shimp , Guobao Wei , Keyvan Behnam
发明人： Lawrence A. Shimp , Guobao Wei , Keyvan Behnam
IPC分类号： A61K35/32
CPC分类号： A61L27/3691 , A61F2/4644 , A61F2002/4646 , A61L27/30 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/48 , A61L27/50 , A61L2430/40 , C08L67/04
摘要： In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
摘要翻译： 在一个实施方案中，该方法包括提供组织，制备组织和处理组织以改善组织的重塑特征。 组织可以是例如皮质骨。 处理组织以改善重塑特征可以包括加热组织，用化学品或其它物质处理组织。 加热组织可以在没有氧的情况下进行，并且可以包括在真空中加热组织，在惰性气氛中加热组织，在还原性气氛中加热组织，用保护涂层涂覆组织并加热组织，或 其他。 另外的实施方案包括处理超临界流体中的组织，例如干燥或病毒灭活组织。
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公开(公告)号：US20110054408A1
公开(公告)日：2011-03-03
申请号：US12705330
申请日：2010-02-12
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp , Sigurd Berven , Randal R. Betz , Michael F. O'Brien , Alexis Shelokov , Robert Cohen , Alexander Vaccaro , Scott Boden , Harvinder Sandhu , Daryl R. Sybert , Munish Chandra Gupta , Georgiana Shelokov
CPC分类号： A61F2/28 , A61B17/68 , A61B17/7022 , A61B17/7059 , A61B17/7097 , A61B17/8085 , A61F2/0095 , A61F2/2846 , A61F2/3099 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30576 , A61F2002/30581 , A61F2002/30622 , A61F2002/3068 , A61F2002/30971 , A61F2250/0068
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施例中，覆盖物适用于各种程序特定用途。 可以提供植入工具用于将覆盖物放置在手术部位。 可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。
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公开(公告)号：US08545864B2
公开(公告)日：2013-10-01
申请号：US11773775
申请日：2007-07-05
申请人： John W. Morris , David A. Knaack , Lawrence A. Shimp , Keyvan Behnam , Robert P. Skinner , Randal R. Betz
发明人： John W. Morris , David A. Knaack , Lawrence A. Shimp , Keyvan Behnam , Robert P. Skinner , Randal R. Betz
CPC分类号： A61L27/3608 , A61L24/0005 , A61L24/046 , A61L27/18 , A61L27/3683 , A61L27/54 , A61L2300/418 , A61L2400/04 , C08L71/02
摘要： The present invention provides a hemostatic bone graft product and method. Hemostatic bone grafts may include demineralized bone matrix in combination with additives. In one embodiment, the graft comprises demineralized bone and polyethylene glycol. Methods for producing the hemostatic bone graft may include mixing demineralized bone with additives to facilitate protein precipitation, surface tension reduction in blood, and/or a cytolytic effect on cells at a bleeding site.
摘要翻译： 本发明提供止血性骨移植物产品及方法。 止血骨移植物可以包括与添加剂组合的脱矿质骨基质。 在一个实施方案中，移植物包含软化骨和聚乙二醇。 用于制备止血骨移植物的方法可以包括将脱矿质骨与添加剂混合以促进蛋白沉淀，血液中的表面张力降低和/或在出血部位的细胞的溶细胞效应。
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公开(公告)号：US20090192474A1
公开(公告)日：2009-07-30
申请号：US12171125
申请日：2008-07-10
申请人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
发明人： Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构，直到将覆盖物放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。
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