公开(公告)号：US20160020082A1

公开(公告)日：2016-01-21

申请号：US14773902

申请日：2014-01-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kiyomi YOSHINARI ,  Yasushi TERUI

IPC: H01J49/42 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/426 ,  H01J49/0031 ,  H01J49/0422 ,  H01J49/0431 ,  H01J49/4215 ,  H01J49/4225 ,  H01J49/429

Abstract: An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit 8 controls a mass spectrometry unit 4 so that a direct current voltage U, an amplitude V of a radio-frequency voltage, and a frequency F of the radio-frequency voltage, which are applied to a quadrupole electrode 13, are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger. By controlling in this manner, the ion frequency when the ion passes through the inside of the mass spectrometry unit 4 is increased as the mass number of an ion becomes higher, and therefore, it is possible to obtain the mass spectrum with higher resolution.

Abstract translation: 本发明的目的是提供一种当离子的质量数变高时能够以高分辨率获得质谱的质谱仪系统。 在本发明的质谱仪系统中，控制单元8控制质谱分析单元4，使得直流电压U，射频电压的振幅V和射频电压的频率F是 施加到四极电极13时，随着质谱法的离子的质荷比m / z变大而增加。 通过以这种方式进行控制，当离子通过质谱分析单元4的内部时的离子频率随着离子的质量数变高而增加，因此可以获得具有更高分辨率的质谱。

公开(公告)号：US20190027350A1

公开(公告)日：2019-01-24

申请号：US16069066

申请日：2016-01-21

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shinichi MURAKAMI ,  Yasushi TERUI

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/025 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/4215

Abstract: An object of the invention is to provide a mass spectrometry device and an ion detection method therefor in which an ion amount can be detected with high accuracy.In order to achieve the object described above, a mass spectrometry device is provided which performs a channel scan measurement by changing a voltage to be applied to a mass separation unit to selectively extract a desired ion. The mass spectrometry device includes: an ion detection unit which detects an ion separated by the mass separation unit and outputs an electric signal; an ion amount measuring unit which measures an ion amount from the output of the ion detection unit; and an ion amount correction unit which corrects a detection amount of ion from an output of the ion amount measuring unit. In a process of a channel scan, the ion amount correction unit performs correction of a detection amount of ion detected in a present channel based on a detection amount of ion in a previous channel.

公开(公告)号：US20180269049A1

公开(公告)日：2018-09-20

申请号：US15542505

申请日：2016-01-04

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi YOSHINARI ,  Yasushi TERUI

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/42

CPC classification number: H01J49/0063 ,  G01N27/62 ,  H01J49/4215 ,  H01J49/4255

Abstract: With regard to an object of the invention, in a tandem type mass spectrometry system including three stages of a QMS, sensitivity of a daughter ion decreases due to loss resulting from destabilization of the daughter ion or a decrease in daughter ion generation rate, and an improvement insensitivity of the daughter ion is a significant issue. To solve the above-mentioned problem, the invention provides a mass spectrometry system having means of decreasing a q value of a parent ion and not decreasing a fundamental vibration frequency of the parent ion. According to the means of the invention, the invention may have effects that amass number range of a daughter ion that may be stably transmitted is expanded, the number of vibrations of a parent ion is substantially the same as that in a first stage of the QMS, and generation efficiency of the daughter ion does not decrease and can be maintained.

公开(公告)号：US20210159063A1

公开(公告)日：2021-05-27

申请号：US16618198

申请日：2018-05-01

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi YOSHINARI ,  Yasushi TERUI

IPC: H01J49/04 ,  H01J49/24 ,  H01J49/02

Abstract: The mass spectrometer includes an ionization unit that ionizes a sample; a nozzle unit having an inflow port that is connected to the ionization unit by a flow pipe and through which the ionized sample flows, and an outflow port from which the sample flowing in flows out; a vacuum chamber that is evacuated by vacuum evacuation means and into which the sample flows from the nozzle unit; a mass analysis unit that is located downstream of a flow of the sample relative to the vacuum chamber and that selects ions from the sample; and an ion detection unit that detects the ions selected by the mass analysis unit, wherein a division portion that divides a flow of the sample is provided inside the nozzle unit, and the division portion has a tapered projection whose diameter decreases toward the outflow port.

公开(公告)号：US20190006164A1

公开(公告)日：2019-01-03

申请号：US16060132

申请日：2016-11-09

Applicant: Hitachi High-Technologies Corporation

Inventor： Kiyomi YOSHINARI ,  Yasushi TERUI

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/42

Abstract: Acceleration of decelerated ions and a reduction in the velocity dispersion width of decelerated ions are both achieved, whereby the sensitivity of detected ion sensitivity is improved and resolution is improved. The distance dx between at least one set of facing rod-shaped electrodes among rod-shaped electrodes (4-2-a) to (4-2-d) differs at the inlet part at which ions enter and the outlet part at which ions exit, and the distance dx between the at least one set of facing rod-shaped electrodes is gradually reduced or increased from the inlet part toward the outlet part.

公开(公告)号：US20150371837A1

公开(公告)日：2015-12-24

申请号：US14762916

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki YASUDA ,  Shinya ITO ,  Akira FUJII ,  Yasushi TERUI

IPC: H01J49/04 ,  G01N30/72

CPC classification number: H01J49/0445 ,  G01N30/724 ,  H01J49/165

Abstract: A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.

Abstract translation: 质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。 特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。 该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。 因此，期望的样品的电离稳定，并且测量再现性提高。