公开(公告)号：US20190317061A1

公开(公告)日：2019-10-17

申请号：US16472587

申请日：2016-12-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Hiroaki NAKAGAWA ,  Taku SAKAZUME ,  Shinya ITO ,  Tsukasa SHISHIKA

IPC: G01N30/60 ,  G01N30/32

Abstract: The present invention provides a column exchange device for simpler column exchange and a column suitable for this column exchange device. A column exchange mechanism according to the present invention is provided with a column having inward-facing threads at both ends thereof and a first joining part and second joining part for fixing the ends of the column. The column exchange mechanism is characterized in that the first joining part and second joining part have screw parts that are joined to the ends of the column and the direction in which the screw of the screw part of the first joining part is to be turned to tighten the same and the direction in which the screw of the screw part of the second joining part is to be turned to tighten the same are opposite directions.

公开(公告)号：US20170160273A1

公开(公告)日：2017-06-08

申请号：US15320406

申请日：2015-06-17

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO ,  Tadao YABUHARA

IPC: G01N33/543 ,  G01N15/12 ,  G01N33/82 ,  G01N30/72

CPC classification number: G01N33/54326 ,  G01N15/12 ,  G01N15/1209 ,  G01N30/7233 ,  G01N33/82 ,  G01N35/025 ,  G01N35/08 ,  G01N35/1095 ,  G01N2015/0065

Abstract: When using an immunological analysis method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring by spectroscopy, and a mass spectrometry method wherein antigen-antibody reactions are used to form complexes of microparticles and a substance being measured, purifying, then measuring with a mass spectrometer, the amount of the complex flowing in the flow path for immunological analysis and the amount of the complex flowing in the flow path for mass spectrometry are unknown, so the substance being measured cannot be accurately quantified even when merging information obtained from immunological analysis and information obtained from mass spectrometry. The invention provides a mechanism for quantifying the complexes after formation of the complexes, on the flow path for mass spectrometry and the flow path for immunological analysis.

公开(公告)号：US20160195561A1

公开(公告)日：2016-07-07

申请号：US14911406

申请日：2014-06-24

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO ,  Tadao YABUHARA

IPC: G01N35/02 ,  G01N35/10 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N35/025 ,  G01N33/54366 ,  G01N35/00871 ,  G01N35/1065 ,  G01N2001/2826 ,  G01N2035/0458

Abstract: An analysis device is provided with a first disk on which a sample container and disposable container can be disposed, a second disk on which a solid-phase extraction cartridge and disposable container can be disposed, a first probe capable of transferring a sample of the sample container disposed on the first disk or a solution of the disposable container disposed on the first disk to the solid-phase extraction cartridge or disposable container disposed on the second disk, and a second probe capable of transferring a reagent of a reagent container to the sample container or disposable container disposed on the first disk and the solid-phase extraction cartridge or disposable container disposed on the second disk. Sample preprocessing before solid-phase extraction processing takes place on the first disk.

Abstract translation: 分析装置设置有第一盘，可以在其上放置样品容器和一次性容器;第二盘，其上可以设置固相提取盒和一次性容器;第一探针，其能够将样品的样品 将容器设置在第一盘上，或者将设置在第一盘上的一次性容器的溶液放置在设置在第二盘上的固相提取盒或一次性容器中，以及能够将试剂容器的试剂转移到样品的第二探针 设置在第一盘上的容器或一次性容器以及设置在第二盘上的固相提取盒或一次性容器。 固相萃取处理前的样品预处理在第一个磁盘上进行。

公开(公告)号：US20200340957A1

公开(公告)日：2020-10-29

申请号：US16083308

申请日：2016-03-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Makoto NOGAMI ,  Shinya ITO

IPC: G01N30/28 ,  G01N30/72 ,  G01N30/14 ,  G01N30/20

Abstract: An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

公开(公告)号：US20160109417A1

公开(公告)日：2016-04-21

申请号：US14894633

申请日：2014-05-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Jun NUNOSHIGE ,  Shinya ITO ,  Hiroshi NAKANO

IPC: B01J20/281 ,  B01J20/288 ,  B01J20/32 ,  B01J20/28

CPC classification number: G01N30/482 ,  B01D15/08 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3253 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/52 ,  G01N30/72 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/484

Abstract: An adsorbent which enables solid phase extraction of water-soluble molecules with high efficiency and excellent selectivity and an analysis system using the adsorbent, the adsorbent containing a structure represented by the formula I wherein R is a carrier component, the moiety other than R is a side-chain functional group, R and the benzene ring in the side-chain functional group are bonded directly or bonded through one or more atoms, R′ is selected from the group consisting of hydroxy group, alkoxy group, amino group, alkylamino group, thiol group and alkyl sulfide group, R″ is independently selected from the group consisting of hydroxy group, alkoxy group, alkyl group, amino group, alkylamino group, dialkylamino group, trialkylamino group, thiol group, alkyl sulfide group and hydrogen atom, x is an integer of zero or more and three or less, and n is the number of the side-chain functional groups contained in the carrier component.

Abstract translation: 能够以高效率和优异的选择性固相萃取水溶性分子的吸附剂和使用该吸附剂的分析系统，该吸附剂含有式I所示的结构，其中R为载体组分，除R外的部分为 侧链官能团，R和侧链官能团中的苯环直接键合或通过一个或多个原子键合，R'选自羟基，烷氧基，氨基，烷基氨基， 硫醇基和烷基硫基，R“独立地选自羟基，烷氧基，烷基，氨基，烷基氨基，二烷基氨基，三烷基氨基，硫醇基，烷基硫基和氢原子，x是 0以上且3以下的整数，n为载体成分中所含的侧链官能团的数。

公开(公告)号：US20150371837A1

公开(公告)日：2015-12-24

申请号：US14762916

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki YASUDA ,  Shinya ITO ,  Akira FUJII ,  Yasushi TERUI

IPC: H01J49/04 ,  G01N30/72

CPC classification number: H01J49/0445 ,  G01N30/724 ,  H01J49/165

Abstract: A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.

Abstract translation: 质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。 特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。 该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。 因此，期望的样品的电离稳定，并且测量再现性提高。

公开(公告)号：US20150308986A1

公开(公告)日：2015-10-29

申请号：US14651247

申请日：2013-10-21

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Shinya ITO ,  Shigeo MUTO

IPC: G01N30/20 ,  G01N30/72 ,  H01J49/04

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/7233 ,  G01N30/7266 ,  G01N35/08 ,  G01N2030/009 ,  G01N2030/207 ,  H01J49/0431

Abstract: Provided herein is a sample injection method that enables efficient injection of a trace sample solution while reducing the measurement time. A sample solution is injected into a sample loop with air layers disposed on both sides of the sample solution, and the total amount of the sample solution, including the air layers, is injected into a detector. The start and the end of data collection are determined from the detection signal intensity changes that occur upon the air layers being injected into the detector, and the velocity of the flowing liquid is increased to reduce the measurement time. A washing solution is injected after the air layer to improve the washing efficiency and reduce the washing time.

Abstract translation: 本文提供了一种样品注射方法，其能够在减少测量时间的同时有效注入痕量样品溶液。 将样品溶液注入样品环，其中设置在样品溶液两侧的空气层，并将样品溶液（包括空气层）的总量注入检测器中。 数据采集​​的开始和结束是从在空气层被注入检测器中发生的检测信号强度变化确定的，流动液体的速度增加以减少测量时间。 在空气层之后注入洗涤液以提高洗涤效率并减少洗涤时间。