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19 条记录 (耗时 0.029 秒)

    VGF fusion polypeptides
    1.
    发明申请
    VGF fusion polypeptides 审中-公开
    VGF融合多肽

    公开(公告)号：US20070010662A1

    公开(公告)日：2007-01-11

    申请号：US11329372

    申请日：2006-01-10

    申请人： Hai Yan ,  Thomas Boone

    发明人： Hai Yan ,  Thomas Boone

    IPC分类号： C07K14/475 ,  C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.

    摘要翻译： 本发明提供新型VGF多肽和选择性结合剂。 本发明还提供用于产生VGF多肽的宿主细胞和方法。 本发明还提供用于诊断，治疗，改善和/或预防与VGF多肽相关的疾病，病症和病症的VGF药物组合物和方法。

    VGF polypeptides and methods of treating VGF-related disorders
    2.
    发明申请
    VGF polypeptides and methods of treating VGF-related disorders 审中-公开
    VGF多肽和治疗VGF相关疾病的方法

    公开(公告)号：US20050049180A1

    公开(公告)日：2005-03-03

    申请号：US10424385

    申请日：2003-04-25

    申请人： Hai Yan ,  Thomas Boone

    发明人： Hai Yan ,  Thomas Boone

    IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/18 ,  C07K14/475 ,  C08G63/48 ,  C08G63/91

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.

    摘要翻译： 本发明提供新型VGF多肽和选择性结合剂。 本发明还提供用于产生VGF多肽的宿主细胞和方法。 本发明还提供用于诊断，治疗，改善和/或预防与VGF多肽相关的疾病，病症和病症的VGF药物组合物和方法。

    Method of making devices having thin dielectric layers
    4.
    发明授权
    Method of making devices having thin dielectric layers 有权
    制造具有薄介电层的器件的方法

    公开(公告)号：US06294447B1

    公开(公告)日：2001-09-25

    申请号：US09351971

    申请日：1999-07-12

    申请人： Thomas Boone ,  Joseph Mark Rosamilia

    发明人： Thomas Boone ,  Joseph Mark Rosamilia

    IPC分类号： H01L213205

    CPC分类号： H01L21/28211 ,  H01L21/02238 ,  H01L21/02255 ,  H01L21/31111 ,  H01L21/31662

    摘要： A method for making a thin dielectric layer is disclosed which is useful in fabricating semiconductor devices, particularly transistors and DRAM cell devices. The method comprises a two-steps, i.e., (i) growing a base layer of dielectric material on a substrate having a thickness in excess of the desired thickness for the layer, and (ii) etching back the base layer to the desired thickness. With these two steps, a thin dielectric layer of less than 20 Å may be provided having substantial uniformity across its surface with a standard deviation in surface contours of less than 0.7 Å.

    摘要翻译： 公开了制造薄介电层的方法，其可用于制造半导体器件，特别是晶体管和DRAM单元器件。 该方法包括两步，即（i）在基底上生长具有超过该层所需厚度的厚度的介电材料的基底层，以及（ii）将基底层刻蚀成所需厚度。 通过这两个步骤，可以提供小于20埃的薄介电层，其表面具有基本均匀性，表面轮廓的标准偏差小于0.7。

    Integrated wire management device for audio headphones
    5.
    发明授权
    Integrated wire management device for audio headphones 有权

    公开(公告)号：US10177508B2

    公开(公告)日：2019-01-08

    申请号：US15721924

    申请日：2017-10-01

    申请人： Thomas Boone

    发明人： Thomas Boone

    IPC分类号： H01R13/72 ,  B65H75/44 ,  B65H75/28 ,  H04R1/10 ,  H04R5/033

    摘要： A wire management device for storing an earphone wire having a signal terminal and a pair of speakers includes an elongated frame having first and second ends, the frame having a first channel to hold a first wrapped part of the wire, first and second beaks respectively arranged at the first and second ends of the frame to stay the terminal of the wire, and first and second wings respectively branching from neighboring positions of the first and second ends the frame, the first and second wings are, respectively, bent toward the first and second ends of the frame for wrapping the wire, wherein at least one of the wings includes a clamping portion to clamp a last wrapped part of the wire.

    INTEGRATED WIRE MANAGEMENT DEVICE FOR AUDIO HEADPHONES
    6.
    发明申请
    INTEGRATED WIRE MANAGEMENT DEVICE FOR AUDIO HEADPHONES 审中-公开

    公开(公告)号：US20180109049A1

    公开(公告)日：2018-04-19

    申请号：US15721924

    申请日：2017-10-01

    申请人： Thomas Boone

    发明人： Thomas Boone

    IPC分类号： H01R13/72 ,  H04R5/033 ,  B65H75/28 ,  B65H75/44

    CPC分类号： H01R13/72 ,  B65H75/285 ,  B65H75/446 ,  B65H75/4476 ,  B65H2701/3919 ,  B65H2701/536 ,  H04R1/1033 ,  H04R5/033

    摘要： A wire management device for storing an earphone wire having a signal terminal and a pair of speakers includes an elongated frame having first and second ends, the frame having a first channel to hold a first wrapped part of the wire, first and second beaks respectively arranged at the first and second ends of the frame to stay the terminal of the wire, and first and second wings respectively branching from neighboring positions of the first and second ends the frame, the first and second wings are, respectively, bent toward the first and second ends of the frame for wrapping the wire, wherein at least one of the wings includes a clamping portion to clamp a last wrapped part of the wire.

    Modified peptides as therapeutic agents
    9.
    发明申请
    Modified peptides as therapeutic agents 有权
    修饰肽作为治疗剂

    公开(公告)号：US20050123548A1

    公开(公告)日：2005-06-09

    申请号：US10645784

    申请日：2003-08-18

    申请人： Ulrich Feige ,  Chuan-Fa Liu ,  Janet Cheetham ,  Thomas Boone

    发明人： Ulrich Feige ,  Chuan-Fa Liu ,  Janet Cheetham ,  Thomas Boone

    IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K14/505 ,  C07K14/52 ,  C07K14/525 ,  C07K14/545 ,  C12N9/64 ,  A61K39/395 ,  C07K16/24 ,  C07K16/46

    CPC分类号： C12N9/6491 ,  A61K38/00 ,  A61K47/62 ,  C07K14/505 ,  C07K14/52 ,  C07K14/524 ,  C07K14/525 ,  C07K14/545 ,  C07K2319/00 ,  C07K2319/30

    摘要： The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologically active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising: a) selecting at least one peptide that modulates the activity of a protein of interest; and b) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide. Linkage to the vehicle increases the half-life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide can be selected, for example, by phage display, E. coli display, ribosome display, RNA-peptide screening, yeast-based screening, chemical-peptide screening, rational design, or protein structural analysis.

    摘要翻译： 本发明涉及Fc结构域与生物活性肽的融合以及使用生物活性肽制备药物的方法。 在本发明中，药理活性化合物通过以下方法制备，该方法包括：a）选择至少一种调节目的蛋白质活性的肽; 和b）制备包含与选定肽的至少一个氨基酸共价连接的Fc结构域的药理学试剂。 与载体的连接增加了肽的半衰期，否则其将在体内迅速降解。 优选的载体是Fc结构域。 肽可以例如通过噬菌体展示，大肠杆菌展示，核糖体展示，RNA-肽筛选，酵母筛选，化学肽筛选，合理设计或蛋白质结构分析来选择。

    Novel EMR structure with bias control and enhanced linearity of signal
    10.
    发明申请
    Novel EMR structure with bias control and enhanced linearity of signal 失效
    具有偏置控制和增强信号线性度的新型EMR结构

    公开(公告)号：US20070247763A1

    公开(公告)日：2007-10-25

    申请号：US11411606

    申请日：2006-04-25

    申请人： Thomas Boone ,  Liesl Folks ,  Stefan Maat

    发明人： Thomas Boone ,  Liesl Folks ,  Stefan Maat

    IPC分类号： G11B5/33

    CPC分类号： G11B5/3993 ,  G11B2005/0016 ,  G11C11/14

    摘要： An extraordinary magnetoresistive device EMR having a discontinuous shunt structure. The discontinuous shunt structure improves the linearity of response of the EMR device. The EMR device includes a EMR heterostructure that includes an EMR active layer. The heterostructure can include first, second and third semiconductor layers, with the second layer being sandwiched between the first and third layers. The middle, or second semiconductor layer provides a two dimensional electron gas. The heterostructure has first and second opposed sides, with a pair of voltage leads and a pair of current leads connected with the first side of the structure. The discontinuous shunt structure is connected with the second side of the structure and may be in the form of a series of discontinuous, electrically conductive elements, such as semi-spherical gold elements.

    摘要翻译： 具有不连续分流结构的非凡磁阻器件EMR。 不连续的分流结构提高了EMR器件的响应线性。 EMR器件包括EMR异质结构，其包括EMR有源层。 异质结构可以包括第一，第二和第三半导体层，第二层夹在第一和第三层之间。 中间或第二半导体层提供二维电子气。 异质结构具有第一和第二相对侧，一对电压引线和一对与结构的第一侧连接的电流引线。 不连续的分流结构与结构的第二侧连接，并且可以是一系列不连续的导电元件，例如半球状金元素的形式。