利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

31 条记录 (耗时 0.044 秒)

    Method of screening cell death modulators
    3.
    发明申请
    Method of screening cell death modulators 失效
    筛选细胞死亡调节剂的方法

    公开(公告)号：US20060057721A1

    公开(公告)日：2006-03-16

    申请号：US10543651

    申请日：2004-01-29

    申请人： Urmas Arumae ,  Li-Ying Yu ,  Mart Saarma

    发明人： Urmas Arumae ,  Li-Ying Yu ,  Mart Saarma

    IPC分类号： C40B40/10 ,  G01N33/53 ,  C12N5/08

    CPC分类号： C12Q1/37 ,  G01N2500/00 ,  G01N2510/00

    摘要： The invention provides methods and compositions for identifying agents which modulate cell death, indicated e.g. by the expression of caspase-2 and/or caspase-7, in GDNF family growth factor deprived neuronal or nonneuronal cells. The methods for identifying such agents find particular application in drug development.

    摘要翻译： 本发明提供了用于鉴定调节细胞死亡的药剂的方法和组合物， 通过caspase-2和/或caspase-7的表达，在GDNF家族生长因子被剥夺的神经元或非神经元细胞中。 识别这些药剂的方法在药物开发中具有特殊应用。

    Intracellular Signaling-Induced Ret-Independent Gdnf Receptor-Effected Morphological Changes
    4.
    发明申请
    Intracellular Signaling-Induced Ret-Independent Gdnf Receptor-Effected Morphological Changes 审中-公开
    细胞内信号诱导的Ret独立Gdnf受体影响的形态学变化

    公开(公告)号：US20080070264A1

    公开(公告)日：2008-03-20

    申请号：US10548147

    申请日：2004-03-05

    申请人： Hannu Sariola ,  Anna E. Popsueva ,  Mart Saarma

    发明人： Hannu Sariola ,  Anna E. Popsueva ,  Mart Saarma

    IPC分类号： G01N33/574 ,  C12Q1/02

    CPC分类号： G01N33/502

    摘要： The invention provides methods for identifying modulators of RETindependent, GDNF effected intracellular signaling. The invention further provides methods of identifying useful modulators of RET-independent GDNF receptoreffected MET activation, as well as modulators of morphological responses which are effected by nonRET GDNF receptor-effected intracellular signaling. Methods of distinguishing RET-independent GDNF ligand-mediated intracellular signaling by different cellular GDNF receptors from RET-dependent intracellular signaling are provided. The methods of the invention also provide an understanding of the complex interrelationships between RET, MET, GFRa in response to GDNF ligands.

    摘要翻译： 本发明提供用于鉴定RET独立型GDNF调节因子影响细胞内信号传导的方法。 本发明还提供鉴定RET独立性GDNF受体影响的MET活化的有用调节剂的方法，以及由非-RET GDNF受体影响的细胞内信号传导影响的形态反应调节剂。 提供了区分不依赖于RET依赖性细胞内信号传导的不同细胞GDNF受体的RET独立GDNF配体介导的细胞内信号转导的方法。 本发明的方法还提供了对响应于GDNF配体的RET，MET，GFRa之间的复杂相互关系的理解。

    Compounds related to or derived from GFR α4 and their use
    6.
    发明授权
    Compounds related to or derived from GFR α4 and their use 失效
    与GFRα4有关或衍生自GFRα4的化合物及其用途

    公开(公告)号：US07488588B1

    公开(公告)日：2009-02-10

    申请号：US10203639

    申请日：2000-11-14

    申请人： Matti Airaksinen ,  Mart Saarma ,  Dimitri Poteriaev ,  Maria Lindahl ,  Tönis Timmusk ,  Jari Rossi

    发明人： Matti Airaksinen ,  Mart Saarma ,  Dimitri Poteriaev ,  Maria Lindahl ,  Tönis Timmusk ,  Jari Rossi

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C12P21/06 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention discloses purified and isolated nucleic acid sequences encoding polypeptides having a structure substantially similar to that of splicing forms of mammalian GFRα4 comprising the amino acid sequence (SEQ ID NO:1:)-(SEQ ID NO:6:). The preferred sequences comprise cDNAs having the sequence (SEQ ID NO:7:)-(SEQ ID NO:13:). The present invention is also related to purified and isolated polypeptides comprising the amino acid sequence and or substantially similar splicing forms of mammalian GFRà4. Furthermore, the invention is related to substances capable of specifically recognizing said polypeptides and including both antibodies and receptors. The active compounds of the present invention including cDNAS, polypeptides, binding substances, and antibodies. The invention is useful not only for producing cell-lines and/or transgenic non-human animal but also for diagnosing and treating neuronal disorders or endocrine tumors as well as other related diseases by enabling measurements of GFRα4-mediated signalling in endocrine cells and neurons.

    摘要翻译： 本发明公开了编码具有与包含氨基酸序列（SEQ ID NO：1：） - （SEQ ID NO：6））的哺乳动物GFRα4剪接形式基本相似的结构的多肽的纯化和分离的核酸序列。 优选的序列包含具有序列（SEQ ID NO：7：） - （SEQ ID NO：13 :)的cDNA。 本发明还涉及包含哺乳动物GFRà4的氨基酸序列和/或基本相似的剪接形式的纯化和分离的多肽。 此外，本发明涉及能够特异性识别所述多​​肽并包括抗体和受体的物质。 本发明的活性化合物包括cDNAS，多肽，结合物质和抗体。 本发明不仅可用于生产细胞系和/或转基因非人类动物，还可用于诊断和治疗神经元疾病或内分泌肿瘤以及其他相关疾病，方法是测量GFRalpha4介导的内分泌细胞和神经元信号。