Purification of immunoglobulins
    1.
    发明申请
    Purification of immunoglobulins 有权
    免疫球蛋白的纯化

    公开(公告)号:US20060134805A1

    公开(公告)日:2006-06-22

    申请号:US11315402

    申请日:2005-12-22

    IPC分类号: G01N33/558

    摘要: The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilised, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is between 65-84 μm. The carbohydrate material is preferably highly cross-linked agarose.

    摘要翻译: 本发明涉及由多孔颗粒组成的分离基质,抗体结合蛋白质配体已经固定在其上,其中配体密度在5.0-10mg / ml的范围内; 对于大小为110kDa的葡聚糖,表示为K 的颗粒的凝胶相分布系数高于0.65,中值粒径在65-84μm之间。 碳水化合物材料优选是高度交联的琼脂糖。

    Purification of immunoglobulins
    2.
    发明授权
    Purification of immunoglobulins 有权
    免疫球蛋白的纯化

    公开(公告)号:US08728828B2

    公开(公告)日:2014-05-20

    申请号:US11315402

    申请日:2005-12-22

    IPC分类号: G01N33/543

    摘要: The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilized, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is between 65-84 μm. The carbohydrate material is preferably highly cross-linked agarose.

    摘要翻译: 本发明涉及由多孔颗粒组成的分离基质,抗体结合蛋白质配体已经固定在其上,其中配体密度在5.0-10mg / ml的范围内; 表示为大小为110kDa的葡聚糖的Kav的颗粒的凝胶相分布系数大于0.65,中值粒径在65-84μm之间。 碳水化合物材料优选是高度交联的琼脂糖。

    Regeneration Of A Chromatography Matrix
    3.
    发明申请
    Regeneration Of A Chromatography Matrix 审中-公开
    色谱法再生

    公开(公告)号:US20080230478A1

    公开(公告)日:2008-09-25

    申请号:US11913101

    申请日:2006-05-22

    IPC分类号: B01D15/08 B01D24/46

    CPC分类号: C07K1/22 B01D15/203

    摘要: The present invention relates to a process of regenerating a separation matrix, such as a chromatography matrix, comprising adsorption of at least one target molecule by contacting a mobile phase comprising at target molecule(s) with a matrix; removal of unbound material by washing the matrix; elution of target molecule(s) by contacting the matrix with an eluent; reducing regeneration by contacting said matrix with a reducing agent; alkaline regeneration by contacting the matrix with an alkaline solution; and equilibration of the matrix.

    摘要翻译: 本发明涉及再生分离基质如色谱基质的方法,其包括通过使包含靶分子的流动相与基质接触来吸附至少一种靶分子; 通过洗涤基质去除未结合的材料; 通过使基质与洗脱液接触来洗脱目标分子; 通过使所述基质与还原剂接触来减少再生; 通过使基质与碱性溶液接触进行碱性再生; 并平衡基质。

    Antibody purification
    4.
    发明申请
    Antibody purification 有权
    抗体纯化

    公开(公告)号:US20070112178A1

    公开(公告)日:2007-05-17

    申请号:US10589718

    申请日:2005-02-24

    IPC分类号: C07K16/00 C02F1/28

    摘要: The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system. In one embodiment, the ring-forming atoms of the aromatic or hereoaromatic entity are selected among C, S or O, and the cation exchanging group is a weak cation exchanger. The present method may be used as a single step procedure or as a polishing step following a capture on a Protein A column.

    摘要翻译: 本发明涉及一种从溶液中的污染物中分离抗体的方法,该方法包括使该溶液与包含固定有多元配体的载体的色谱树脂接触,其中多模式配体包含至少一个 阳离子交换基团和至少一个芳族或杂芳族环系统。 在一个实施方案中,芳族或非芳族实体的成环原子选自C,S或O,并且阳离子交换基团是弱阳离子交换剂。 本方法可以用作单步骤程序或作为在蛋白A柱上捕获后的抛光步骤。

    Sizing dispersions
    5.
    发明授权
    Sizing dispersions 失效
    调整分散体

    公开(公告)号:US5876562A

    公开(公告)日:1999-03-02

    申请号:US849180

    申请日:1997-05-28

    申请人: Hans Johansson

    发明人: Hans Johansson

    IPC分类号: D21H17/17 D21H17/68 D21H21/16

    CPC分类号: D21H17/68 D21H17/17 D21H21/16

    摘要: An aqueous anionic sizing dispersion which comprises an anionic dispersion of a cellulose-reactive sizing agent and colloidal anionic aluminum modified silica-based particles. The dispersion is used in the production of paper, board or cardboard whereby the dispersion is either added to the stock or applied as a surface size.

    摘要翻译: PCT No.PCT / SE95 / 01446 Sec。 371日期1997年5月28日 102(e)日期1997年5月28日PCT提交1995年12月1日PCT公布。 公开号WO96 / 17127 日期1996年6月6日一种含水阴离子上浆分散体,其包含纤维素反应性施胶剂和胶态阴离子铝改性二氧化硅基颗粒的阴离子分散体。 分散体用于生产纸张,纸板或纸板,由此将分散体添加到原料中或作为表面尺寸施加。

    Method for ignition timing control in combustion engines
    6.
    发明授权
    Method for ignition timing control in combustion engines 失效
    内燃机点火正时控制方法

    公开(公告)号:US5676113A

    公开(公告)日:1997-10-14

    申请号:US628606

    申请日:1996-04-11

    摘要: An improved method applied in combustion engines which use the ionization current in the combustion chamber in order to extract a parameter representative of the pressure in the cylinder, which parameter is used for controlling the ignition timing within an extended range for the load- and speed range. The method is based on an integration of a parameter dependent on the ionization current. In a first embodiment, the mass center position of the integral is calculated, which mass center position is used as a position corresponding to the peak pressure position. The ignition timing is adjusted in such a manner that the mass center position, and hence the peak pressure position, strives to obtain a predetermined target value. In a second embodiment, an integrated value is calculated, which take into account the mechanics of the combustion engine, in such a way that the integrated value corresponds to a value representative of the torque transmitted to the crankshaft. By optimizing the integrated value, the torque transmitted to the crankshaft can be optimized as well, obtaining an optimal usage of the fuel-air mixture supplied.

    摘要翻译: PCT No.PCT / SE95 / 00912 Sec。 371日期:1996年4月11日 102(e)日期1996年4月11日PCT提交1995年8月8日PCT公布。 公开号WO96 / 05427 日期1996年2月22日一种改进的方法应用在内燃机中,其使用燃烧室中的电离电流,以便提取代表气缸中的压力的​​参数,该参数用于将点火正时控制在扩展范围内 负载和速度范围。 该方法基于取决于电离电流的参数的积分。 在第一实施例中,计算积分的质量中心位置,哪个质量中心位置用作对应于峰值压力位置的位置。 调整点火正时,使得质量中心位置,从而使峰值压力位置努力获得预定的目标值。 在第二实施例中,以积分值对应于表示传递到曲轴的扭矩的值的方式计算积分值,该积分值考虑了内燃机的力学特性。 通过优化积分值,也可以优化传递到曲轴的扭矩,从而获得所提供的燃料 - 空气混合物的最佳使用。

    Method for achieving an elevated charge of an ignition capacitor in a
capacitive type ignition system
    8.
    发明授权
    Method for achieving an elevated charge of an ignition capacitor in a capacitive type ignition system 失效
    在电容式点火系统中实现点火电容器的高电荷的方法

    公开(公告)号:US4907562A

    公开(公告)日:1990-03-13

    申请号:US274317

    申请日:1988-11-18

    CPC分类号: F02P3/093 F02P15/12 F02B1/04

    摘要: The invention relates to a method for achieving elevated charging of an ignition capacitor in a capacitive type ignition system for internal combustion engines. When starting a cold engine or when starting the engine under other conditions in which the battery capacity is low, activation of the engine starting motor will result in a drop in voltage in the electric system serving both the starting motor and the ignition system. The voltage drop in the electrical system will vary sinusoidally synchronously with the crankshaft rotation, owing to the fact that the starting motor will momentarily subject the electrical system to higher loads when the pistons are located adjacent their top-dead-center position L in the compression stroke. The method solves this problem, by delaying the re-charging of the capacitor until a position is reached in which the voltage drop in the electrical system has its lowest value.

    Method and arrangement for improving the starting ability of an internal
combustion engine during an engine start
    9.
    发明授权
    Method and arrangement for improving the starting ability of an internal combustion engine during an engine start 失效
    在发动机起动期间提高内燃机起动能力的方法和装置

    公开(公告)号:US4903676A

    公开(公告)日:1990-02-27

    申请号:US236665

    申请日:1988-08-25

    摘要: The invention relates to a method and an arrangement for improving the starting ability of an internal combustion engine during difficult engine starting conditions that result from cold weather or other external circumstances. Lower than normal engine starting speeds can occur during cold weather, for example. So as not to hinder an engine start, it is essential that the spark plugs be free from deposits and in their best condition. This is achieved by burning off any deposits present on spark plugs during an engine start attempt, when difficult engine starting conditions are detected. During an engine start attempt a comparison circuit ascertains whether or not one or more detected engine parameters have a lower value than in normal engine starting conditions. The comparison circuit sends a signal to the control unit controlling the ignition system, so that the control unit will initiate the generation of a plurality of sparks, instead of a single spark, at ignition time points. The resultant spark shower then burns off any deposits that are present.

    Vacuum based diverter switch for tap changer
    10.
    发明授权
    Vacuum based diverter switch for tap changer 有权
    用于分接开关的真空切换开关

    公开(公告)号:US08367951B2

    公开(公告)日:2013-02-05

    申请号:US12438375

    申请日:2007-08-23

    IPC分类号: H01H3/32

    CPC分类号: H01H9/0038 H01H9/0044

    摘要: A retrofit diverter switch which has a mechanical and electrical interface that is compatible with the existing designs is provided. The diverter switch may include a vacuum switch. The feature where the mechanical and electrical interface is compatible enables a retrofit from traditional On Load Tap Changers to a vacuum based on Load Tap Changers. The diverter switch may be retrofitted into existing tap changer housings. Retrofitting from traditional to vacuum based, traditional to vacuum based and up rating, and vacuum up rating may be possible. Also, the diverter switch may include modular components that allow for easy customization of the diverter switch for different applications.

    摘要翻译: 提供具有与现有设计兼容的机械和电气接口的改型切换开关。 切换开关可包括真空开关。 机械和电气接口兼容的功能使得可以将传统的带负载分接头变换器改装为基于负载分接开关的真空。 切换开关可以改装成现有的分接开关壳体。 从传统到真空,从传统到真空和升级,以及真空升级等级都是可能的。 此外,切换开关可以包括允许用于不同应用的切换开关的容易定制的模块化部件。