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公开(公告)号：US5420149A
公开(公告)日：1995-05-30
申请号：US25493
申请日：1993-03-03
申请人： Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Husch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch , Ulrich Niewohner
发明人： Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Husch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch , Ulrich Niewohner
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61P9/10 , A61P35/00 , C07C69/614 , C07D233/60 , C07D233/68 , C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12
CPC分类号： C07D233/68
摘要： Imidazolyl-substituted phenylacetic acid derivatives are prepared by first reacting suitably substituted phenylacetic acid with imidazoles and subsequently converting the product into an amide. The compounds can be employed as active compounds in medicaments, in particular for treating hypertension and atherosclerosis.
摘要翻译： 咪唑基取代的苯乙酸衍生物通过首先使适当取代的苯乙酸与咪唑反应并随后将产物转化为酰胺来制备。 该化合物可以用作药物中的活性化合物，特别是用于治疗高血压和动脉粥样硬化。
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公开(公告)号：US5318980A
公开(公告)日：1994-06-07
申请号：US18961
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/415 , A61K31/40 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/64 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/535 , A61K31/495
CPC分类号： C07D401/12 , C07D233/68 , C07D403/12
摘要： Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
摘要翻译： 磺酰基苄基取代的咪唑可以通过首先使咪唑基醛与磺酰基苄基化合物反应，然后以常规方式氧化或还原醛官能团来制备。 磺酰苄基取代的咪唑可用作药物中的活性化合物。
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公开(公告)号：US5364942A
公开(公告)日：1994-11-15
申请号：US18964
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/435 , A61K31/40 , A61K31/445 , A61K31/675 , A61P9/12 , A61P43/00 , C07D205/04 , C07D207/16 , C07D207/48 , C07D211/60 , C07D211/96 , C07D295/26 , C07D401/04 , C07D403/04 , C07D413/04 , C07D471/04 , C07F9/6561 , A61K31/415 , A61K31/44 , C07D471/06
CPC分类号： C07D295/26 , C07D207/48 , C07D211/96 , C07D471/04
摘要： Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment of hypertension and atherosclerosis.
摘要翻译： 磺酰基苄基取代的咪唑并吡啶可以通过使相应取代的咪唑并吡啶与磺酰基苄基化合物反应来制备。 磺酰基苄基取代的咪唑并吡啶可用作药物中的活性化合物，特别是用于治疗高血压和动脉粥样硬化。
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公开(公告)号：US5352687A
公开(公告)日：1994-10-04
申请号：US25479
申请日：1993-03-03
申请人： Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch
发明人： Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/68 , C07D233/90 , C07D401/12 , C07D405/12 , C07D409/06 , A61K31/535 , A61K31/47 , C07D407/10 , C07D413/10
CPC分类号： C07D401/12 , C07D233/68 , C07D405/12
摘要： Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis.
摘要翻译： 取代的苯基乙酰胺可以通过将适当取代的苯乙酸与咪唑反应并随后进行酰胺化来制备。 取代的苯乙酸衍生物可用于治疗高血压和动脉粥样硬化的药物中。
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公开(公告)号：US5475016A
公开(公告)日：1995-12-12
申请号：US19001
申请日：1993-02-18
申请人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/40 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61P9/02 , A61P9/10 , C07D233/54 , C07D233/64 , C07D233/66 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/14 , C07F9/38 , C07F9/40 , C07F9/6509 , A61K31/415
CPC分类号： C07D233/64 , C07D233/68 , C07D401/12 , C07D403/12 , C07D409/06 , C07D409/14
摘要： Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.
摘要翻译： 磺酰基苄基取代的咪唑基丙烯酸衍生物可以通过使磺酰基苄基取代的醛与合适的CH-酸性化合物反应然后脱水来制备。 磺酰基苄基取代的咪唑基丙烯酸衍生物可用于药物中，特别是用于治疗高血压和动脉粥样硬化。
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6.发明授权Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists 失效作为血管紧张素II受体拮抗剂的磺酰基苄基取代的吡啶酮
公开(公告)号：US5254543A
公开(公告)日：1993-10-19
申请号：US19000
申请日：1993-02-18
申请人： Rudolf Hanko , Walter Hubsch , Jurgen Dressel , Peter Fey , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人： Rudolf Hanko , Walter Hubsch , Jurgen Dressel , Peter Fey , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号： A61K31/44 , A61K31/40 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , C07D213/79 , C07D401/12 , C07D401/14 , C07F9/6558 , C07D401/10
CPC分类号： C07D401/12 , C07D401/14 , C07F9/65583
摘要： Sulphonylbenzyl-substituted pyridones can be prepared by reacting pyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 磺酰基苄基取代的吡啶酮可以通过使吡啶酮与磺酰基苄基化合物反应来制备。 磺酰基苄基取代的吡啶酮可以用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号：US5863930A
公开(公告)日：1999-01-26
申请号：US574082
申请日：1995-12-18
申请人： Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07D213/79 , C07D401/10
CPC分类号： C07D401/10
摘要： Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.
摘要翻译： 三取代的联苯通过相应的吡啶酮与联苯基甲基卤化合物反应来制备。 三取代的联苯可用作药物中的活性化合物。
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公开(公告)号：US5407948A
公开(公告)日：1995-04-18
申请号：US239197
申请日：1994-05-06
申请人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/50 , A61K31/53 , A61P9/10 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/64 , C07D213/71 , C07D213/76 , C07D213/78 , C07D213/79 , C07D401/10 , C07D401/14
CPC分类号： C07D401/14
摘要： Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 取代的单 - 和二吡啶基甲基吡啶酮通过吡啶酮与单吡啶基或联吡啶甲基卤化合物的反应或通过吡啶酮取代的卤代吡啶与四唑基苯基硼酸的反应来制备。 取代的单吡啶基和联吡啶基甲基吡啶酮可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号：US5414008A
公开(公告)日：1995-05-09
申请号：US80854
申请日：1993-06-21
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
IPC分类号： A61K31/415 , A61P43/00 , C07D233/54 , C07D233/64 , C07D233/66 , C07D233/68 , C07D233/90 , C07D403/10
CPC分类号： C07D233/64 , C07D233/68 , C07D403/10
摘要： Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The imidazolyl-substituted phenylpropionic and cinnamic acid derivatives can be used as active compounds in medicaments, in particular in the treatment of arterial hypertension and atherosclerosis.
摘要翻译： 咪唑基取代的苯丙酸和肉桂酸衍生物通过使适当的苄基化合物与咪唑反应并任选改变取代基来制备。 咪唑基取代的苯丙酸和肉桂酸衍生物可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号：US5708003A
公开(公告)日：1998-01-13
申请号：US525933
申请日：1995-09-08
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D403/10 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/435 , A61K31/44 , A61P9/10 , A61P9/12 , A61P43/00 , C07D209/86 , C07D209/90 , C07D209/94 , C07D213/86 , C07D257/04 , C07D401/10 , C07D471/04
CPC分类号： C07D471/04 , C07D209/86
摘要： Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
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