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    Regulation of gene expression by protein methylation
    2.
    发明授权
    Regulation of gene expression by protein methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US08247168B2

    公开(公告)日：2012-08-21

    申请号：US12573066

    申请日：2009-10-02

    申请人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    发明人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    IPC分类号： C12Q1/48 ,  C12Q1/68 ,  C12N9/10

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Regulation of Gene Expression By Protein Methylation
    3.
    发明申请
    Regulation of Gene Expression By Protein Methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US20080051560A1

    公开(公告)日：2008-02-28

    申请号：US11736504

    申请日：2007-04-17

    申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

    发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

    IPC分类号： C07K16/00

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Regulation of gene expression by protein methylation
    4.
    发明申请
    Regulation of gene expression by protein methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US20050176092A1

    公开(公告)日：2005-08-11

    申请号：US10830591

    申请日：2004-04-22

    申请人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

    发明人： Michael Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana Aswad

    IPC分类号： C12N9/10 ,  C12P21/06

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Regulation of gene expression by protein methylation
    6.
    发明授权
    Regulation of gene expression by protein methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US07214510B2

    公开(公告)日：2007-05-08

    申请号：US10830591

    申请日：2004-04-22

    申请人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    发明人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    IPC分类号： C12P21/00 ,  C07K1/113 ,  C12N9/10

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Regulation of gene expression by protein methylation
    7.
    发明授权
    Regulation of gene expression by protein methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US06743614B1

    公开(公告)日：2004-06-01

    申请号：US09464377

    申请日：1999-12-15

    申请人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    发明人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    IPC分类号： C12N910

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。