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公开(公告)号：US20190193076A1
公开(公告)日：2019-06-27
申请号：US16098976
申请日：2016-07-14
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5085 , B01L3/50853 , B01L2200/025 , B01L2200/0689 , B01L2300/0627
摘要： A microplate lid is disclosed. An electronics board includes a plurality of board throughholes corresponding to well locations of a microplate. A cover plate includes a plurality of plate throughholes corresponding to respective board throughholes to define a plurality of plate-board throughhole pairs. The cover plate is located atop the electronics board. A plurality of directing lumens is at least partially defined by the cover plate. Each directing lumen corresponds to a respective plate throughhole. A plurality of user-perceptible array indicators is provided to the electronics board. Each array indicator is associated with a different plate-board throughhole pair than every other array indicator.
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公开(公告)号：US20210088540A1
公开(公告)日：2021-03-25
申请号：US16603671
申请日：2017-09-27
IPC分类号： G01N35/00
摘要： In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes detecting a pause signal due to a surface load error. Corrective actions are initiated in response to the pause signal. A continue signal is received after the corrective actions are completed and a correct microplate is loaded into the fluid dispensing apparatus. Fluids are then dispensed into wells of the correct microplate.
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公开(公告)号：US20210060542A1
公开(公告)日：2021-03-04
申请号：US16605915
申请日：2017-09-27
发明人： David OCHS , Jeffrey A. NIELSEN
摘要： Examples disclosed herein relate to a device. Examples devices include a dispense routine engine to determine a first dispense routine for a first compound in a first chamber and a second compound in a second chamber. The dispense routine engine to determine a second dispense routine for the first compound and the second compound in response to a cancel chamber request for the second chamber and a chamber designation request for the second compound in a third chamber. Example devices include a dispense engine to control the dispense device to cancel dispensing of the second compound from the second chamber and to dispense at least a portion of the first compound from the first chamber and at least a portion of the second compound from the third chamber according to the second dispense routine.
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公开(公告)号：US20210008547A1
公开(公告)日：2021-01-14
申请号：US16603460
申请日：2017-09-15
IPC分类号： B01L3/00 , G01N35/10 , C12Q1/6844
摘要： Examples disclosed herein relate to a device. Examples include a region selection engine to determine a plurality of regions on a well plate, a number of wells in each region, and a location of each well in each region; and a dispense engine to determine a quantity of DNA concentrate under 1 microliter to dispense in each well of the plurality of regions on the well plate, and the dispense engine to control a fluid dispensing device to eject the quantity of DNA concentrate into each well of each region of the well plate. In examples, a quantity of DNA fragments in the DNA concentrate is unknown.
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公开(公告)号：US20220297113A1
公开(公告)日：2022-09-22
申请号：US17836005
申请日：2022-06-09
发明人： Jeffrey A. NIELSEN , Michael W. CUMBIE , Devin Alexander MOUREY , Silam J. CHOY , Kenneth WARD , Christie DUDENHOEFER
IPC分类号： B01L3/02
摘要： A method of manufacturing a digital dispense apparatus includes molding a monolithic carrier structure, forming cut outs into a planar top surface of the monolithic carrier structure, the cut outs including a reservoir extending into part of a thickness of the monolithic carrier structure and fluid routing to connect the reservoir with a fluid dispense device, and overmolding the fluid dispense device into the monolithic carrier structure on a side of the monolithic carrier structure that is opposite to the reservoir to fluidically connect to the fluid routing.
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公开(公告)号：US20220203349A1
公开(公告)日：2022-06-30
申请号：US17607309
申请日：2019-07-31
摘要： Aspects of the present disclosure relate to evaporation compensation in fluidic devices. An example apparatus for evaporation compensation includes an assessment circuit to determine an amount of evaporation of a volume dispensed in a microwell of a fluidic device. The amount of evaporation may be determined based on the volume in the microwell, and an amount of time after dispensing the volume in the microwell. A compensation circuit may determine, based on the amount of evaporation, a compensation factor for the microwell including an amount of a normalizing fluid to compensate for the amount of evaporation. The compensation circuit may also create a normalization profile for the fluidic device, including an association between the fluidic device and the compensation factor. A dispensing circuit may dispense the normalizing fluid in the microwell according to the normalization profile.
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公开(公告)号：US20190083972A1
公开(公告)日：2019-03-21
申请号：US16085342
申请日：2016-03-31
发明人： Jeffrey A. NIELSEN , Michael W. CUMBIE , Devin Alexander MOUREY , Silam J. CHOY , Christie DUDENHOEFER , Kenneth WARD
摘要： A digital dispense apparatus comprising a plurality of fluid dispense devices, at least one reservoir connected to the plurality of fluid dispense devices to deliver fluid to the plurality of fluid dispense devices, at least one contact pad array, and a single monolithic carrier structure.
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公开(公告)号：US20220314212A1
公开(公告)日：2022-10-06
申请号：US17608091
申请日：2019-07-26
发明人： Jeffrey A. NIELSEN , Debora THOMAS
摘要： An apparatus including a fluidic input and a die including a microfluidic chamber, may receive a biologic sample. The microfluidic chamber may include a foyer to contain a portion of the biologic sample, and an inlet impedance-based sensor to detect passage of a cell of the biologic sample into the foyer. A target nozzle may eject a first volume, corresponding with a target concentration of cells of the biologic sample. A spittoon nozzle may eject a second volume of the portion of the biologic sample into a spittoon location. An output impedance-based sensor may be disposed within a threshold distance of the target nozzle to detect passage of a cell of the biologic sample into the target nozzle. Moreover, the apparatus may include circuitry to control firing of the target nozzle and the spittoon nozzle based on signals received from the inlet impedance-based sensor and the output impedance-based sensor.
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公开(公告)号：US20210165007A1
公开(公告)日：2021-06-03
申请号：US17044996
申请日：2018-06-04
发明人： Jeffrey A. NIELSEN , Christie DUDENHOEFER , Debora J. THOMAS , Roberto A. PUGLIESE , Diane R. HAMMERSTAD
摘要： In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes a plurality of ejection subassemblies. Each ejection subassembly includes an ejection chamber to hold a volume of fluid and an opening through which the volume of fluid is ejected via a fluid actuator. A pitch of the ejection subassemblies aligns with a spatial arrangement of nanowells in an array of nanowells on a substrate.
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公开(公告)号：US20210011045A1
公开(公告)日：2021-01-14
申请号：US16603476
申请日：2017-09-15
IPC分类号： G01N35/10 , B01L3/02 , C12Q1/6844
摘要： Examples disclosed herein relate to a device. Examples include a region selection engine to determine a plurality of regions on a well plate, a number of wells in each region, and a location of each well in each region; and a dispense engine to determine a quantity of DNA concentrate to dispense in each well of the plurality of regions on the well plate, and the dispense engine to control a fluid dispensing device to eject the quantity of DNA concentrate into each well of each region of the well plate. In examples, a quantity of DNA fragments in the DNA concentrate is unknown.
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