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公开(公告)号：US07612115B2
公开(公告)日：2009-11-03
申请号：US11374450
申请日：2006-03-13
IPC分类号： A61K47/00 , A61K31/715 , A61K31/47
CPC分类号： A61K31/5383 , A61K9/0048 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent.The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa·s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.
摘要翻译： 本发明的目的在于提供一种抗菌水性药物组合物和含水药物组合物，即使新的喹诺酮类抗菌剂如氧氟沙星作为活性成分，也能够在施用部位长时间保留，具有足够低的凝胶化温度 由于施用后的粘度快速增加，尽管它们在施用时是液体，从而获得药剂的高可用性。 本发明涉及一种抗菌水性药物组合物，其包含：2.8〜4w / v％的甲基纤维素，其2w / v％水溶液在20℃下的粘度为12mPa·s或更低。 1.5至2.3w / v％的柠檬酸; 2至4w / v％的聚乙二醇; 和0.1至0.5w / v％的氧氟沙星。
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公开(公告)号：US20060172969A1
公开(公告)日：2006-08-03
申请号：US11374450
申请日：2006-03-13
IPC分类号： A61K31/717 , A61K31/496
CPC分类号： A61K31/5383 , A61K9/0048 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent. The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa·s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.
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公开(公告)号：US20080318272A1
公开(公告)日：2008-12-25
申请号：US11667590
申请日：2005-11-14
申请人： Mari Yamamoto , Masanobu Kirita , Manabu Sami , Mitsuo Ikeda
发明人： Mari Yamamoto , Masanobu Kirita , Manabu Sami , Mitsuo Ikeda
CPC分类号： C12N15/52 , C12N9/1007 , C12P17/06
摘要： A gene encoding a methylated catechin synthase that can effectively synthesize methylated catechins having high antiallergic activity.The gene encoding a methylated catechin synthase contains at least one nucleotide sequence selected from the group consisting of SEQ ID NOs: 1, 3 and 5.
摘要翻译： 编码能有效合成具有高抗过敏活性的甲基化儿茶素的甲基化儿茶素合成酶的基因。 编码甲基化儿茶素合成酶的基因含有至少一个选自SEQ ID NO：1,3和5的核苷酸序列。
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公开(公告)号：US07879586B2
公开(公告)日：2011-02-01
申请号：US11667590
申请日：2005-11-14
申请人： Mari Yamamoto , Masanobu Kirita , Manabu Sami , Mitsuo Ikeda
发明人： Mari Yamamoto , Masanobu Kirita , Manabu Sami , Mitsuo Ikeda
IPC分类号： C12P21/00 , C12N15/00 , C12N1/21 , C12N5/10 , C12N5/04 , C12Q1/48 , C07H21/00 , C12N9/10 , C07K14/00
CPC分类号： C12N15/52 , C12N9/1007 , C12P17/06
摘要： A gene encoding a methylated catechin synthase that can effectively synthesize methylated catechins having high antiallergic activity.The gene encoding a methylated catechin synthase contains at least one nucleotide sequence selected from the group consisting of SEQ ID NOs: 1, 3 and 5.
摘要翻译： 编码能有效合成具有高抗过敏活性的甲基化儿茶素的甲基化儿茶素合成酶的基因。 编码甲基化儿茶素合成酶的基因含有至少一个选自SEQ ID NO：1,3和5的核苷酸序列。
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5.发明申请公开(公告)号：US20100324312A1
公开(公告)日：2010-12-23
申请号：US12449345
申请日：2008-01-21
申请人： Mari Yamamoto , Masanobu Kirita , Daiki Honma , Toyokazu Yokota
发明人： Mari Yamamoto , Masanobu Kirita , Daiki Honma , Toyokazu Yokota
IPC分类号： C07D311/62
CPC分类号： C07D311/62 , A23L33/10 , A61K8/498 , A61K2800/72 , A61Q3/02 , A61Q5/02 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C12P17/06
摘要： A novel methylated catechin is provided which has stronger antiallergic activity than conventionally known methylated catechins such as epigallocatechin-3-O-(3-O-methyl)gallate and epigallocatechin-3-O-(4-O-methyl)gallate.The epigallocatechin-3-O-gallate derivative is represented by the chemical formula I: (wherein R1 to R6 are each a hydrogen atom or a methyl group, and at least three of R1 to R6 are methyl groups) or an isomer thereof.
摘要翻译： 提供了一种新颖的甲基化儿茶素，其具有比常规已知的甲基化儿茶素类如表没食子儿茶素-3-O-（3-O-甲基）没食子酸酯和表没食子儿茶素-3-O-（4-O-甲基）没食子酸酯具有更强的抗过敏活性。 表示的没食子儿茶素没食子酸酯的衍生物由化学式I（其中R 1至R 6各自为氢原子或甲基，并且R 1至R 6中的至少三个为甲基）或其异构体。
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6.发明申请公开(公告)号：US20090205068A1
公开(公告)日：2009-08-13
申请号：US11659342
申请日：2005-08-04
CPC分类号： A61K38/168 , C07K14/415 , C12N15/8257
摘要： The present invention relates to: a method for producing a transgenic plant expressing miraculin, comprising introducing a miraculin gene into a useful plant that can be easily produced and cultivated throughout the year using plant molecular breeding technology; a transgenic plant expressing miraculin, which is produced by the method; and the use thereof. The present invention also relates to a food additive, a food or drink, or an antidiabetic drug, which contains miraculin that is produced by the transgenic plant.
摘要翻译： 本发明涉及：用于生产表达miraculin的转基因植物的方法，包括将miraculin基因引入可利用植物分子育种技术在一年中容易地生产和培育的有用植物中; 通过该方法生产表达miraculin的转基因植物; 及其用途。 本发明还涉及包含由转基因植物产生的miraculin的食品添加剂，食品或饮料或抗糖尿病药物。
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