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公开(公告)号：US08003851B2
公开(公告)日：2011-08-23
申请号：US12063888
申请日：2006-08-10
CPC分类号： C12P19/26 , C12N15/8257
摘要： It is intended to provide by improving a known method of producing hyaluronic acid in a plant, a plant or a cultured plant cells which can produce hyaluronic acid at a lower cost and a further higher yield than before, a method of preparing the same, an expression vector for transformation, a method of producing hyaluronic acid using the plant or the cultured plant cells and the like. The method of producing hyaluronic acid comprising obtaining hyaluronic acid by co-expressing a protein with hyaluronic acid synthase activity and an exogenous protein with sugar-nucleotide synthase activity in a plant cell or a plant is provided.
摘要翻译： 本发明旨在通过改善可以以比以前更低的成本和更高的产量生产透明质酸的植物，植物或培养的植物细胞中制备透明质酸的已知方法，其制备方法， 用于转化的表达载体，使用植物或培养的植物细胞等产生透明质酸的方法。 提供了通过在植物细胞或植物中共同表达具有透明质酸合成酶活性的蛋白质和具有糖 - 核苷酸合成酶活性的外源蛋白质来获得透明质酸的方法。
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公开(公告)号：US20090260108A1
公开(公告)日：2009-10-15
申请号：US12063888
申请日：2006-08-10
CPC分类号： C12P19/26 , C12N15/8257
摘要： It is intended to provide by improving a known method of producing hyaluronic acid in a plant, a plant or a cultured plant cells which can produce hyaluronic acid at a lower cost and a further higher yield than before, a method of preparing the same, an expression vector for transformation, a method of producing hyaluronic acid using the plant or the cultured plant cells and the like. The method of producing hyaluronic acid comprising obtaining hyaluronic acid by co-expressing a protein with hyaluronic acid synthase activity and an exogenous protein with sugar-nucleotide synthase activity in a plant cell or a plant is provided.
摘要翻译： 本发明旨在通过改善可以以比以前更低的成本和更高的产量生产透明质酸的植物，植物或培养的植物细胞中制备透明质酸的已知方法，其制备方法， 用于转化的表达载体，使用植物或培养的植物细胞等产生透明质酸的方法。 提供了通过在植物细胞或植物中共同表达具有透明质酸合成酶活性的蛋白质和具有糖 - 核苷酸合成酶活性的外源蛋白质来获得透明质酸的方法。
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3.发明授权Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof 有权包括生物表面活性剂作为活性成分的活化剂，甘露糖基赤藓糖醇脂质及其制备方法公开(公告)号：US07989599B2
公开(公告)日：2011-08-02
申请号：US12367870
申请日：2009-02-09
申请人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
发明人： Michiko Suzuki , Masaru Kitagawa , Shuhei Yamamoto , Atsushi Sogabe , Dai Kitamoto , Tomotake Morita , Tokuma Fukuoka , Tomohiro Imura
CPC分类号： C07H15/04 , A23L33/10 , A61K8/60 , A61K31/7032 , A61K36/06 , A61Q19/08 , C07H15/06 , C11D1/662
摘要： The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-β-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.
摘要翻译： 本发明包括作为活性成分的至少一种生物表面活性剂，特别是甘露糖基糖醇脂质（如MEL和MML）或三酰化甘露糖基糖醇脂质。 这提供了对细胞的活化和抗衰老作用优异的活化剂和抗老化剂，并且长时间安全使用，还提供化妆品，准药物，药物和饮料和食品 包括活化剂和抗老化剂作为活性成分。 此外，本发明提供了分子结构中的甘露糖基赤藓糖醇骨架为1-O-和 - D-吡喃甘露糖基 - 内消旋赤藓糖醇的MEL及使用微生物制备MEL的方法。
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4.发明申请Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same 审中-公开表面处理剂，表面处理粉末和包含其的化妆品公开(公告)号：US20080081029A1
公开(公告)日：2008-04-03
申请号：US11576705
申请日：2005-10-06
申请人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
发明人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
CPC分类号： C09C3/10 , A61K8/11 , A61K8/8158 , A61K2800/412 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q17/04 , C01P2004/10 , C01P2004/20 , C08F220/28 , C09C1/027 , C09C1/28 , C09C1/3676 , C09C1/405 , C09C3/12
摘要： To provide surface-treating agents that can provide excellent hydrophobicity to powder and can improve its rinsability, to provide surface-treated powders that are treated with the surface-treating agent, and to provide cosmetics that comprise the surface-treated powder. A surface-treating agent consisting of a polymer which comprises a monomer (A) represented by the general formula (1) described below as a constituent monomer. (wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkylene group having 4 to 22 carbon atoms, X1 represents an —NH— group or an oxygen atom, and M1 represents a hydrogen atom or a monovalent inorganic or organic cation.)
摘要翻译： 为了提供能够为粉末提供优异的疏水性并可提高其漂洗性的表面处理剂，提供用表面处理剂处理的表面处理粉末，以及提供包含表面处理粉末的化妆品。 由下述通式（1）表示的单体（A）作为构成单体的聚合物构成的表面处理剂。 （其中R 1表示氢原子或具有1至3个碳原子的烷基，R 2表示具有4至22个碳原子的亚烷基，X < 1表示-NH-基或氧原子，M 1表示氢原子或一价无机或有机阳离子。）
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公开(公告)号：US20070203303A1
公开(公告)日：2007-08-30
申请号：US10592727
申请日：2005-04-05
申请人： Atsushi Sogabe , Isamu Kaneda
发明人： Atsushi Sogabe , Isamu Kaneda
IPC分类号： C08F255/02
CPC分类号： A61Q19/00 , A61K8/895 , C08F299/02 , C08F299/08 , Y10S525/91 , Y10S525/911
摘要： The invention is an alternating copolymer, and a method of producing the same, obtained by alternately copolymerizing a vinylbenzyl-terminated polyethylene oxide (or polydimethylsiloxane) and a (meth)acryloyl-terminated polydimethylsiloxane (or polyethylene oxide). The alternating copolymer is a novel amphiphilic brush-shaped alternating copolymer having a structure that is well-suited as an emulsifier or a dispersant for oil and silicone solvents commonly used in cosmetics and pharmaceuticals.
摘要翻译： 本发明是通过交替共聚乙烯基苄基封端的聚环氧乙烷（或聚二甲基硅氧烷）和（甲基）丙烯酰基封端的聚二甲基硅氧烷（或聚环氧乙烷）而获得的交替共聚物及其制备方法。 交替共聚物是具有非常适合用作化妆品和药物中通常使用的油和硅氧烷溶剂的乳化剂或分散剂的结构的新型两亲刷状交替共聚物。
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公开(公告)号：US06884416B2
公开(公告)日：2005-04-26
申请号：US09781703
申请日：2001-02-12
CPC分类号： C12N9/0006 , C12N9/96 , C12Y101/05002
摘要： The present invention provides a stable lyophilized PQQ-dependent glucose dehydrogenase composition comprising a PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected from the group consisting of aspartic acid, glutamic acid, α-ketoglutaric acid, malic acid, α-ketogluconic acid, α-cyclodextrin and their salts and (ii) an albumin.
摘要翻译： 本发明提供一种稳定的冻干的PQQ依赖性葡萄糖脱氢酶组合物，其包含PQQ依赖性葡萄糖脱氢酶以及（i）至少一种选自天冬氨酸，谷氨酸，α-酮戊二酸，苹果酸，α - 酮葡萄糖酸，α-环糊精及其盐和（ii）白蛋白。
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公开(公告)号：US5744342A
公开(公告)日：1998-04-28
申请号：US838418
申请日：1997-04-07
申请人： Atsushi Sogabe , Seiji Takeshima , Kazumi Yamamoto , Shinichi Teshima , Shigenori Emi , Yoshihisa Kawamura
发明人： Atsushi Sogabe , Seiji Takeshima , Kazumi Yamamoto , Shinichi Teshima , Shigenori Emi , Yoshihisa Kawamura
CPC分类号： C12N9/0006
摘要： A novel protein having a heat-resistant malate dehydrogenase activity, a DNA fragment having a gene encoding said protein, a recombinant vector having said DNA fragment, a transformant transformed with said vector, a method for producing the protein having heat-resistant malate dehydrogenase activity by the use of said transformant, a reagent for GOT determination, comprising the above-mentioned novel protein having a heat-resistant malate dehydrogenase activity and a method for determining GOT activity, which comprises the use of said reagent. According to the present invention, a protein having a heat-resistant malate dehydrogenase activity and having higher purity and superior heat stability can be obtained. In addition, a reagent for GOT determination which is superior in long-term storage can be prepared by the use of the protein having a heat-resistant malate dehydrogenase activity.
摘要翻译： 具有耐热苹果酸脱氢酶活性的新型蛋白质，具有编码所述蛋白质的基因的DNA片段，具有所述DNA片段的重组载体，用该载体转化的转化体，具有耐热性苹果酸脱氢酶活性的蛋白质的制造方法 通过使用所述转化体，用于GOT测定的试剂，其包含上述具有耐热苹果酸脱氢酶活性的新型蛋白质和确定GOT活性的方法，其包括使用所述试剂。 根据本发明，可以得到具有耐热苹果酸脱氢酶活性，纯度高，热稳定性优异的蛋白质。 此外，可以通过使用具有耐热苹果酸脱氢酶活性的蛋白质来制备长期保存优良的GOT测定用试剂。
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公开(公告)号：US5686294A
公开(公告)日：1997-11-11
申请号：US270013
申请日：1994-07-01
申请人： Atsushi Sogabe , Seiji Takeshima , Kazumi Yamamoto , Shinichi Teshima , Shigenori Emi , Yoshihisa Kawamura
发明人： Atsushi Sogabe , Seiji Takeshima , Kazumi Yamamoto , Shinichi Teshima , Shigenori Emi , Yoshihisa Kawamura
CPC分类号： C12N9/0006
摘要： A novel protein having a heat-resistant malate dehydrogenase activity, a DNA fragment having a gene encoding said protein, a recombinant vector having said DNA fragment, a transformant transformed with said vector, a method for producing the protein having heat-resistant malate dehydrogenase activity by the use of said transformant, a reagent for GOT determination, comprising the above-mentioned novel protein having a heat-resistant malate dehydrogenase activity and a method for determining GOT activity, which comprises the use of said reagent. According to the present invention, a protein having a heat-resistant malate dehydrogenase activity and having higher purity and superior heat stability can be obtained. In addition, a reagent for GOT determination which is superior in long-term storage can be prepared by the use of the protein having a heat-resistant malate dehydrogenase activity.
摘要翻译： 具有耐热苹果酸脱氢酶活性的新型蛋白质，具有编码所述蛋白质的基因的DNA片段，具有所述DNA片段的重组载体，用该载体转化的转化体，具有耐热性苹果酸脱氢酶活性的蛋白质的制造方法 通过使用所述转化体，用于GOT测定的试剂，其包含上述具有耐热苹果酸脱氢酶活性的新型蛋白质和确定GOT活性的方法，其包括使用所述试剂。 根据本发明，可以得到具有耐热苹果酸脱氢酶活性，纯度高，热稳定性优异的蛋白质。 此外，可以通过使用具有耐热苹果酸脱氢酶活性的蛋白质来制备长期保存优良的GOT测定用试剂。
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9.发明申请Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same 有权表面处理剂，表面处理粉末和包含其的化妆品公开(公告)号：US20110280946A1
公开(公告)日：2011-11-17
申请号：US13113188
申请日：2011-05-23
申请人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
发明人： Shuji Nishihama , Isamu Kaneda , Atsushi Sogabe , Tomo Osawa , Shin-ichi Yusa
IPC分类号： A61K9/16 , C08F22/16 , C08F22/14 , C08F220/38 , C08F220/18 , C08F220/34 , C08F220/28 , C08F230/08 , C08F230/02 , C08F22/38 , C08F220/60
CPC分类号： C09C3/10 , A61K8/11 , A61K8/8158 , A61K2800/412 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q17/04 , C01P2004/10 , C01P2004/20 , C08F220/28 , C09C1/027 , C09C1/28 , C09C1/3676 , C09C1/405 , C09C3/12
摘要： To provide surface-treating agents that can provide excellent hydrophobicity to powder and can improve its rinsability, to provide surface-treated powders that are treated with the surface-treating agent, and to provide cosmetics that comprise the surface-treated powder. A surface-treating agent consisting of a polymer which comprises a monomer (A) represented by the general formula (1) described below as a constituent monomer. (wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkylene group having 4 to 22 carbon atoms, X1 represents an —NH— group or an oxygen atom, and M1 represents a hydrogen atom or a monovalent inorganic or organic cation.)
摘要翻译： 为了提供能够为粉末提供优异的疏水性并可提高其漂洗性的表面处理剂，提供用表面处理剂处理的表面处理粉末，以及提供包含表面处理粉末的化妆品。 由下述通式（1）表示的单体（A）作为构成单体的聚合物构成的表面处理剂。 （其中R1表示氢原子或碳原子数1〜3的烷基，R2表示碳原子数为4〜22的亚烷基，X1表示-NH-基或氧原子，M1表示氢原子或 一价无机或有机阳离子）
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公开(公告)号：US20110237752A1
公开(公告)日：2011-09-29
申请号：US13155243
申请日：2011-06-07
申请人： Atsushi Sogabe , Isamu Kaneda
发明人： Atsushi Sogabe , Isamu Kaneda
IPC分类号： C08F8/00 , C08F228/02
CPC分类号： A61K8/8158 , A61Q5/10 , A61Q19/00 , A61Q19/02 , A61Q19/04 , C08F220/58 , C08F222/385
摘要： The invention is a water-soluble thickener made of a copolymer that is obtained by copolymerizing 2-acrylamido-2-methylpropanesulfonic acid or its salt, hydroxyethylacrylamide, and a crosslinking monomer, or that is made of a copolymer that is obtained by further neutralizing said copolymer that has been obtained using an alkaline agent. It also provides a cosmetic in which this water-soluble thickener has been blended.It is an object of the invention to provide, as a water-soluble thickener, a copolymer which, when blended into a cosmetic, demonstrates a sufficiently satisfactory degree of usability and is excellent in terms of stability and safety.
摘要翻译： 本发明是由2-丙烯酰胺基-2-甲基丙磺酸或其盐，羟乙基丙烯酰胺和交联单体共聚得到的共聚物制成的水溶性增稠剂，或由共聚物制成的共聚物，该共聚物通过进一步中和所述 使用碱性试剂得到的共聚物。 它还提供了一种混合了该水溶性增稠剂的化妆品。 本发明的目的是提供作为水溶性增稠剂的共聚物，当共混到化妆品中时，表现出足够令人满意的可用性，并且在稳定性和安全性方面优异。
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