公开(公告)号：US4450109A

公开(公告)日：1984-05-22

申请号：US417596

申请日：1982-09-13

申请人： Hiromichi Eto ,  Teruo Kohmoto ,  Tadayuki Kouda ,  Youichiro Ogawa ,  Susumu Sato ,  Tadayuki Kuraishi ,  Toshiaki Nakashima

发明人： Hiromichi Eto ,  Teruo Kohmoto ,  Tadayuki Kouda ,  Youichiro Ogawa ,  Susumu Sato ,  Tadayuki Kuraishi ,  Toshiaki Nakashima

IPC分类号： A61K31/54 ,  A61K31/55 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D513/04

CPC分类号： C07D513/04

摘要： The specification describes novel thiazinobenzimidazole derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and X represent a wide variety of substituent groups respectively. The above thiazinobenzimidazole derivatives may be prepared by reacting corresponding 2-hydroxymethyl thiazinobenzimidazole derivatives with corresponding reactive derivatives of carboxylic acid or halogenide or by reacting 2-p-toluenesulfonyloxymethyl-thiazinobenzimidazole derivatives with sodium azides, thiols, phenols or amines. The above thiazinobenzimidazole derivatives wherein X is OH may be prepared by reducing their corresponding 2-alkoxycarbonyl derivatives. Where X represents a p-toluenesulfonyloxy group, the thiazinobenzimidazole derivatives may be obtained by reacting corresponding 2-hydroxymethyl-thiazinobenzimidazole derivatives with p-toluenesulfonyl chloride. Where X stands for an N-substituted 2-(homo)piperazinomethyl group, 2-(homo)piperazinomethyl-thiazinobenzimidazole derivatives are reacted with reactive compounds to introduce the desired substituent groups. The thiazinobenzimidazole derivatives according to this invention are useful as medicament for circulatory systems.

摘要翻译： 该说明书描述了由以下通式表示的新型噻唑并苯并咪唑衍生物：其中R1，R2和X分别代表多种取代基。 上述噻唑并苯并咪唑衍生物可以通过使相应的2-羟甲基噻嗪基苯并咪唑衍生物与羧酸或卤化物的相应反应性衍生物反应或通过2-对甲苯磺酰氧甲基 - 噻嗪基苯并咪唑衍生物与叠氮化钠，硫醇，酚或胺的反应来制备。 其中X是OH的上述噻嗪基苯并咪唑衍生物可以通过还原它们相应的2-烷氧基羰基衍生物来制备。 当X代表对甲苯磺酰氧基时，噻吩并苯并咪唑衍生物可以通过相应的2-羟甲基 - 噻嗪基苯并咪唑衍生物与对甲苯磺酰氯反应而得到。 其中X代表N-取代的2-（均）哌嗪基甲基，2-（高）哌嗪基甲基 - 噻嗪基苯并咪唑衍生物与反应性化合物反应以引入所需的取代基。 根据本发明的噻嗪基苯并咪唑衍生物可用作循环系统的药物。

公开(公告)号：US4369309A

公开(公告)日：1983-01-18

申请号：US240219

申请日：1981-03-03

申请人： Hiromichi Eto ,  Teruo Kohmoto ,  Tadayuki Kouda ,  Youichiro Ogawa ,  Susumu Sato ,  Tadayuki Kuraishi ,  Toshiaki Nakashima

发明人： Hiromichi Eto ,  Teruo Kohmoto ,  Tadayuki Kouda ,  Youichiro Ogawa ,  Susumu Sato ,  Tadayuki Kuraishi ,  Toshiaki Nakashima

IPC分类号： A61K31/54 ,  A61K31/55 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D513/04 ,  C09B23/10 ,  C07D417/14

CPC分类号： C07D513/04

摘要： The specification describes novel thiazinobenzmidazole derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and X represent a wide variety of substituent groups respectively. The above thiazinobenzimidazole derivatives may be prepared by reacting corresponding 2-hydroxymethyl thiazinobenzimidazole derivatives with corresponding reactive derivatives of carbonylic acid or halogenide or by reacting 2-p-toluenesulfonyloxymethyl-thiazinobenzimidazole derivatives with sodium azides, thiols, phenols or amines. The above thiazinobenzimidazole derivatives wherein X in OH may be prepared by reducing their corresponding 2-alkoxycarbonyl derivatives. Where X represents a p-toluenesulfonyloxy group, the thiazinobenzimidazole derivatives may be obtained by reacting corresponding 2-hydroxymethyl-thiazinobenzimidazole derivatives with p-toluenesulfonyl chloride. Where X stands for an N-substituted 2-(homo)piperazinomethyl group, 2-(homo)piperazinomethyl-thiazinobenzimidazole derivatives are reacted with reactive compounds to introduce the desired substituent groups. The thiazinobenzimidazole derivatives according to this invention are useful as medicament for circulatory systems.

摘要翻译： 该说明书描述了由以下通式表示的新型噻嗪并咪唑衍生物：其中R1，R2和X分别代表各种各样的取代基。 上述噻唑并苯并咪唑衍生物可以通过使相应的2-羟甲基噻嗪基苯并咪唑衍生物与羰基酸或卤化物的相应反应性衍生物反应，或通过2-对甲苯磺酰氧基甲基 - 噻嗪基苯并咪唑衍生物与叠氮化钠，硫醇，酚或胺反应来制备。 其中X中的X可以通过还原其相应的2-烷氧基羰基衍生物来制备上述噻唑并苯并咪唑衍生物。 当X代表对甲苯磺酰氧基时，噻吩并苯并咪唑衍生物可以通过相应的2-羟甲基 - 噻嗪基苯并咪唑衍生物与对甲苯磺酰氯反应而得到。 其中X代表N-取代的2-（均）哌嗪基甲基，2-（高）哌嗪基甲基 - 噻嗪基苯并咪唑衍生物与反应性化合物反应以引入所需的取代基。 根据本发明的噻嗪基苯并咪唑衍生物可用作循环系统的药物。

公开(公告)号：US4588822A

公开(公告)日：1986-05-13

申请号：US482409

申请日：1983-04-06

申请人： Junji Oono ,  Kenichi Yano ,  Junichi Sato ,  Tadayuki Kouda ,  Yoichiro Ogawa ,  Kouichi Yokoi ,  Toshiaki Nakashima

发明人： Junji Oono ,  Kenichi Yano ,  Junichi Sato ,  Tadayuki Kouda ,  Yoichiro Ogawa ,  Kouichi Yokoi ,  Toshiaki Nakashima

IPC分类号： C07D309/38 ,  C12P17/06 ,  C07D309/32

CPC分类号： C12R1/465 ,  C07D309/38 ,  C12P17/06 ,  Y10S435/886

摘要： Disclosed are novel physiologically active substance SS 12538, process for its preparation and a novel microorganism producing the same.The novel physiologically active substance SS 12538 is represented by the following formula (I): ##STR1## in which R represents a hydrogen atom, a methyl group or an ethyl group. SS 12538 is obtained by inoculating a novel strain S 12538 in a nutrient-containing medium and cultivating aerobically.SS 12538 has excellent vasodilating action and antibiotic action against a certain gram positive bacteria and dermatophytes.

摘要翻译： 公开了新型生理活性物质SS 12538，其制备方法和生产该生物活性物质的新型微生物。 新型生理活性物质SS 12538由下式（I）表示：其中R表示氢原子，甲基或乙基的式（I）化合物。 通过将新菌株S 12538接种在含营养培养基中并有氧培养获得SS 12538。 SS 12538对某些革兰氏阳性菌和皮肤癣菌具有优异的血管扩张作用和抗生素作用。

公开(公告)号：US20050108873A1

公开(公告)日：2005-05-26

申请号：US10998470

申请日：2004-11-29

申请人： Wataru Hidese ,  Toshiaki Nakashima ,  Hiroshi Haji

发明人： Wataru Hidese ,  Toshiaki Nakashima ,  Hiroshi Haji

IPC分类号： H01L21/00 ,  H01L21/68 ,  H05K13/04 ,  H05K3/30

CPC分类号： H01L21/67259 ,  H01L21/67144 ,  H01L21/681 ,  H05K13/0452 ,  Y10T29/49004 ,  Y10T29/4913 ,  Y10T29/49131 ,  Y10T29/49133 ,  Y10T29/49144 ,  Y10T29/53039 ,  Y10T29/53091 ,  Y10T29/53178 ,  Y10T29/53187 ,  Y10T29/53191 ,  Y10T29/53204

摘要： An electronic parts mount apparatus for taking out electronic parts from a parts supply section 3by a transfer head 9 and transporting and mounting the electronic parts to and on a board 2 has a board recognition camera 15 moving independently of the transfer head 9 and advancing to and retreating from the board 2 positioned on a transfer passage 1 for picking up an image of the board 2 to detect the position thereof. The image pickup step of the board 2 by the board recognition camera 15 and the parts taking out step in the parts supply section by the transfer head 9 are performed concurrently. Thus, the tact time can be shortened and the electronic parts can be mounted on the board efficiently.

摘要翻译： 一种用于通过转印头9从零件供应部分3中取出电子部件并将电子部件运输和安装到板2上的电子部件安装装置具有独立于转印头9移动并前进到 并且从位于传送通道1上的板2退回以拾取板2的图像以检测其位置。 同时执行由板识别摄像机15进行的板2的图像拾取步骤以及由转印头9在零件供给部中取出步骤的部分。 因此，可以缩短生产节拍时间，并且可以有效地将电子部件安装在板上。

公开(公告)号：US5155903A

公开(公告)日：1992-10-20

申请号：US686460

申请日：1991-04-17

申请人： Toshiaki Nakashima ,  Toru Akasaka

发明人： Toshiaki Nakashima ,  Toru Akasaka

IPC分类号： H05K13/04

CPC分类号： H05K13/0413 ,  Y10T29/4913 ,  Y10T29/49144 ,  Y10T29/53178

摘要： There are irregularities in the thicknesses, longitudinal and lateral sizes of electrical components, which cause placement errors of the electrical components on substrates. Therefore, the thickness, longitudinal and lateral sizes of the electrical component is measured during feeding the electrical component to the substrate. The irregularity of the thicknesses of the electrical components can be corrected by regulating the vertical stroke of a nozzle. The temporary values of the longitudinal and lateral sizes of the electrical component are registered in advance in a computer. When the measured values fall within the allowable range of the temporary values, the correction value of the temporary value based on the measured value is corrected, and the correction value is registered as a new reference value in the computer.

摘要翻译： 电气部件的厚度，纵向和横向尺寸存在不规则性，这导致基板上的电气部件的放置误差。 因此，在将电气部件馈送到基板期间测量电气部件的厚度，纵向和横向尺寸。 可以通过调节喷嘴的垂直行程来校正电气部件的厚度的不规则性。 电气部件的纵向和横向尺寸的临时值预先登记在计算机中。 当测量值在临时值的允许范围内时，校正基于测量值的临时值的校正值，并且将校正值作为新的参考值登记在计算机中。

公开(公告)号：US5131139A

公开(公告)日：1992-07-21

申请号：US642763

申请日：1991-01-18

申请人： Kenshu Oyama ,  Toshiaki Nakashima

发明人： Kenshu Oyama ,  Toshiaki Nakashima

IPC分类号： H05K13/04

CPC分类号： H05K13/0413 ,  Y10T29/53091 ,  Y10T29/53178

摘要： A tapered surface is formed on a nozzle for picking up an electrical component and placing it on a printed circuit as a light diffusing surface. When a light is radiated to the tapered surface, the light is scattered, and the tapered surface becomes bright. Therefore, the electrical component is clearly observed as a black contour in the bright tapered surface by an observing unit.

摘要翻译： 锥形表面形成在用于拾取电气部件的喷嘴上并将其放置在作为光漫射表面的印刷电路上。 当光照射到锥形表面时，光被散射，并且锥形表面变亮。 因此，通过观察单元，明亮的锥形表面中的电气部件被清楚地观察为黑色轮廓。

公开(公告)号：US4584377A

公开(公告)日：1986-04-22

申请号：US639113

申请日：1984-08-09

申请人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

发明人： Koichi Yokoi ,  Hiroshi Hasegawa ,  Tadashi Narita ,  Takemitsu Asaoka ,  Kenichi Kukita ,  Seiji Ishizeki ,  Toshiaki Nakashima

IPC分类号： C07D221/20 ,  C07D221/18

CPC分类号： C07D221/20

摘要： Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.

摘要翻译： 本文公开的是由以下通式（I）表示的弗雷德里霉素A衍生物：其中R表示氢原子或酰基，A表示“IMAGE”，虚线键是任选的，条件是 当A为或包含点状键时，R不为氢原子。 它们具有优异的抗菌和抗肿瘤活性，同时与弗雷德霉素A相比非常稳定。

公开(公告)号：US4835287A

公开(公告)日：1989-05-30

申请号：US75616

申请日：1987-07-20

申请人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

发明人： Katsuhiko Nagaoka ,  Masaru Matsumoto ,  Koichi Yokoi ,  Junji Oono ,  Kenichi Kukita ,  Toshiaki Nakashima

IPC分类号： C07G11/00 ,  A61K31/396 ,  A61K31/40 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07D487/04 ,  C07D487/08 ,  C12P1/06 ,  C12P17/18 ,  C12R1/465

CPC分类号： C07D487/08

摘要： A substance SS42227 represented by the following formula (I): ##STR1## in which X represents >CH.sub.2 or >C=CHOH. The substance has antimicrobial and antitumor activities, and thus is useful as a medicine.

摘要翻译： 由下式（I）表示的物质SS42227：其中X表示> CH2或> C = CHOH。 该物质具有抗菌和抗肿瘤活性，因此作为药物有用。

公开(公告)号：US4548753A

公开(公告)日：1985-10-22

申请号：US572242

申请日：1984-01-20

申请人： Susumu Satoh ,  Kinichi Mogi ,  Saburo Murakami ,  Toshiaki Nakashima

发明人： Susumu Satoh ,  Kinichi Mogi ,  Saburo Murakami ,  Toshiaki Nakashima

IPC分类号： A01N37/02 ,  A01N37/06 ,  A61K31/215 ,  A61K31/22 ,  A61K31/23 ,  A61K31/235 ,  C07C69/12 ,  C07C69/16 ,  C07C69/28 ,  C07C69/533 ,  C07C69/58 ,  C07C69/587 ,  C07C69/612 ,  C07C69/614 ,  C09F5/08

CPC分类号： C07C255/00 ,  Y10S514/925

摘要： The specification describes an antiulcer drug containing as an active ingredient a 2,3-butanediol diester derivative represented by the formula (I): ##STR1## where R.sub.A may for example be a saturated or unsaturated alkyl or styryl group and R.sub.B may for example be a saturated or unsaturated alkyl, phenyl, phenylalkyl, phenylpropenyl or phenoxyalkyl group. These groups may optionally be substituted. Many of 2,3-butanediol diester derivatives embraced by the formula (I) are novel. Also described are a novel process for preparing such novel 2,3-butanediol diester derivatives. The 2,3-butanediol diester derivatives of the formula (I) has an action to depress strongly the growth of peptic ulcer and has a very low toxicity.

公开(公告)号：US4501752A

公开(公告)日：1985-02-26

申请号：US487829

申请日：1983-04-22

申请人： Koichi Yokoi ,  Koichi Tachibana ,  Kazuo Isomae ,  Toshiaki Nakashima

发明人： Koichi Yokoi ,  Koichi Tachibana ,  Kazuo Isomae ,  Toshiaki Nakashima

IPC分类号： C07D487/08 ,  A61K31/40 ,  A61P1/04 ,  A61K31/395

CPC分类号： A61K31/40

摘要： An antiulcer drug comprising Ikarugamycin as its active ingredient is disclosed.

摘要翻译： 公开了包含伊卡霉素作为其活性成分的抗溃疡药物。