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公开(公告)号：US5114577A
公开(公告)日：1992-05-19
申请号：US651117
申请日：1991-02-05
CPC分类号： B01J20/28097 , B01D15/08 , B01J20/28014
摘要： A composite separating agent which comprises a hydrophilic polymer separating agent showing a degree of swelling in water of 10 to 100 ml/g-dry and having a giant network structure incorporated within pores of an organic polymer substrate showing a degree of swelling in water of 20 ml/g-dry or below and a degree of crosslinking of 4% to 100% by mol and having a porous structure as well as a process for producing the same are disclosed.When packed within a column, this composite separating agent having a high mechanical strength is hardly compacted and exhibits an excellent separation performance. Thus it is highly useful in chromatographic separation of biopolymers including proteins.
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公开(公告)号：US5006467A
公开(公告)日：1991-04-09
申请号：US213251
申请日：1988-06-29
申请人： Hiroshi Kusano , Tsuyoshi Ito , Hirohisa Kubota
发明人： Hiroshi Kusano , Tsuyoshi Ito , Hirohisa Kubota
CPC分类号： C12N5/0075 , C12N2533/30
摘要： Improved cell culture microcarriers are disclosed herein. These improved microcarriers consist of water-insoluble polymer particles constituted by (meth)acrylic ester, characterized in that the particles have an average diameter of 110-1,000 .mu.m and a density of 1.00-1.20 g/ml in a culture medium as well as positively chargeable chemical moieties distributed at least thereon, the moieties being introduced into the particles by the reaction between the ester and ammonia or amine having 5 or less carbon atoms.
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公开(公告)号：US4906698A
公开(公告)日：1990-03-06
申请号：US329279
申请日：1989-03-27
IPC分类号： C08F2/00 , C08F257/02 , C08F291/00
CPC分类号： C08F257/02 , C08F291/00
摘要： A process for producing crosslinked polymer particles which comprises a first step of polymerizing a polymerizable monomer containing from 0.1 to 2.0% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in a medium in which the polymerizable monomer is soluble but the resulting polymer is insoluble, to obtain crosslinked polymer particles having a particle size of from 0.8 to 10 .mu.m, and a second step of letting the crosslinked polymer particles absorb from 1 to 50 times by weight of a polymerizable monomer containing from 2 to 100% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in an aqueous medium, followed by polymerization to obtain crosslinked polymer particles having a particle size of from 1 to 30 .mu.m and a crosslinking degree of from 1.0 to 98%
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4.发明授权
公开(公告)号：US4863972A
公开(公告)日：1989-09-05
申请号：US70374
申请日：1987-07-07
IPC分类号： C08F8/00 , B01D15/08 , B01J20/26 , B01J20/281 , B01J20/285 , C08F16/02 , C08F16/06 , C08F16/38 , C08J3/16 , C08J9/28 , G01N30/88
CPC分类号： C08J9/283 , B01D15/34 , B01J20/26 , C08J3/16 , B01D15/327 , B01D15/361 , B01D15/3804 , C08J2329/04
摘要： Porous cross-linked polyvinyl alcohol particles which is used for a chromatographic medium is prepared by:dispersing an aqueous solution of a mixture of polyvinyl alcohol and a salt in an organic solvent;allowing a gel to form spontaneously from the dispersion; andreacting the gel with a cross-linking agent.
摘要翻译： 用于色谱介质的多孔交联聚乙烯醇颗粒通过以下方法制备：将聚乙烯醇和盐的混合物的水溶液分散在有机溶剂中; 允许凝胶从分散体自发形成; 并使该凝胶与交联剂反应。
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公开(公告)号：US4696745A
公开(公告)日：1987-09-29
申请号：US849764
申请日：1986-04-09
申请人： Takaharu Itagaki , Hiroshi Kusano , Eiji Miyata , Hirohisa Kubota
发明人： Takaharu Itagaki , Hiroshi Kusano , Eiji Miyata , Hirohisa Kubota
CPC分类号： C08F8/18 , B01J20/267 , B01J20/286
摘要： A method for producing a separating agent having a fluorine-containing group and a hydrophilic group, wherein a cross-linking component consisting of alkylene di(meth)acrylate and/or glycerine poly(meth)acrylate, and a principal chain component consisting of ester and/or ether having therein a polymerizable vinyl group or isopropenyl group and a functional group are subjected to suspension-polymerization to obtain a cross-linked copolymer, and then the functional group in the copolymer is subjected to chemical modification with a fluorine-containing compound or with both fluorine-containing compound and hydrophilic-group-containing compound. The separating agent of the present invention consists essentially of porous cross-linked copolymer particles having porosity in a range of from 0.5 to 3 ml/g and an average particle size in a range of from 1 to 2,000 .mu.m.
摘要翻译： 一种具有含氟基团和亲水基团的分离剂的制备方法，其中由二（甲基）丙烯酸亚烷基酯和/或甘油聚（甲基）丙烯酸酯组成的交联组分和由酯组成的主链组分 和/或其中具有可聚合乙烯基或异丙烯基和官能团的醚进行悬浮聚合以获得交联共聚物，然后将共聚物中的官能团用含氟化合物进行化学改性 或含有含氟化合物和含亲水基团的化合物。 本发明的分离剂基本上由孔隙率为0.5〜3ml / g，平均粒径为1〜2000μm的多孔交联共聚物粒子组成。
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公开(公告)号：US4124422A
公开(公告)日：1978-11-07
申请号：US685152
申请日：1976-05-11
申请人： Hiroshi Kusano
发明人： Hiroshi Kusano
IPC分类号： B29C65/00 , B29C45/00 , B29C55/00 , B29C57/00 , B29C57/04 , B29C65/48 , B29C65/56 , F16L47/06 , B29D23/00 , F16L23/02
CPC分类号： B29C57/00 , B29C57/04 , B29C65/565 , B29C66/5221 , B29C66/52296 , B29C66/52298 , B29C66/5344 , B29C66/7212 , B29C66/7394 , F16L47/06 , B29L2031/24 , Y10T29/49872
摘要： A method is disclosed for the production of flexible pipes having a socket in which a socket element is fixed in overlapping relation to one end portion of a fabricated flexible pipe. The end portion of the pipe is elastically reduced in diameter and the socket element overlapped or telescoped with the reduced end portion. The socket element is then fixed to the reduced end portion of the pipe firmly under elastic stress when the reducing pressure is released. An elastic member may be interposed between the end portion of the pipe and the socket element at the overlap.
摘要翻译： 公开了一种用于生产具有插座的柔性管的方法，其中插座元件与制造的柔性管的一个端部重叠地固定。 管的端部的直径弹性地减小，并且插座元件与减小的端部重叠或伸缩。 然后当释放还原压力时，插座元件在弹性应力下牢固地固定到管道的减小端部。 弹性构件可以以重叠的方式设置在管的端部和插座元件之间。
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公开(公告)号：US4851382A
公开(公告)日：1989-07-25
申请号：US221300
申请日：1988-07-19
IPC分类号： B01J20/291 , B01J20/281 , B01J20/32 , C07B57/00 , C07C67/00 , C07C227/00 , C07C227/34 , C07C229/12 , C07C229/14 , C07C229/22 , C07C229/30 , C07C229/34 , G01N30/88
CPC分类号： B01J20/287 , B01J20/223 , B01J20/28004 , B01J20/28016 , B01J20/28057 , B01J20/28078 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3265 , C07C227/34 , B01J2220/52 , B01J2220/54 , B01J2220/58
摘要： A separation medium useful as an adsorbent of liquid chromatography for optical resolution of racemic mixtures is disclosed, which comprises a reversed phase support coated with an optically active amino acid derivative represented by formula (I): ##STR1## wherein R.sub.1 represents a straight or branched alkyl group having from 1 to 3 carbon atoms; and R.sub.2 and R.sub.3 each represents a straight or branched alkyl group having from 4 to 12 carbon atoms which may contain an aromatic group or an unsaturated alkyl group.The separation medium is applicable to optical resolution of a wide range of DL-amino acids and exhibits excellent durability.
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公开(公告)号：US4476304A
公开(公告)日：1984-10-09
申请号：US409809
申请日：1982-08-20
申请人： Kenji Yokota , Hiroshi Kusano , Ryuichi Sugimoto
发明人： Kenji Yokota , Hiroshi Kusano , Ryuichi Sugimoto
IPC分类号： C07H19/207 , C07F9/6561 , C07F9/65
CPC分类号： C07F9/65618
摘要： A process for the purification of riboflavine-5'-monophosphate comprising subjecting crude riboflavine-5'-monophosphate to chromatography using a column packed with a weakly basic anion-exchange resin having a skeleton of a crosslinked polyacrylic acid ester or polymethacrylic acid ester in which at least a part of the ester linkages thereof are converted into amide linkages represented by the following formula (1): ##STR1## to obtain a fraction of riboflavine-5'-monophosphate containing a reduced amount of impurities from an eluate of the column is disclosed.
摘要翻译： 一种用于纯化核黄素-5'-单磷酸的方法，包括使用含有交联聚丙烯酸酯或聚甲基丙烯酸酯骨架的弱碱性阴离子交换树脂的柱对粗核黄素-5'-单磷酸进行色谱分离，其中， 其酯键的至少一部分转化成由下式（1）表示的酰胺键：（1），从而获得含有来自洗脱液的洗脱液中少量杂质的核黄素-5'-一磷酸的级分 该列被公开。
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公开(公告)号：US5094948A
公开(公告)日：1992-03-10
申请号：US330694
申请日：1989-03-30
申请人： Takao Uchiyama , Akira Kamata , Hiroshi Kusano
发明人： Takao Uchiyama , Akira Kamata , Hiroshi Kusano
CPC分类号： C12N9/1051 , C12N11/08 , C12P19/12 , Y10S435/83
摘要： Disclosed herein is an immobilized enzyme inulin-D-fructotransferase carried in a specific anionic exchange resin with pores having a mode radius in the range of 75 to 2,000 angstroms. The immobilized enzyme of the present invention is effective in the production of DFA III from inulin.
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公开(公告)号：US4908392A
公开(公告)日：1990-03-13
申请号：US329289
申请日：1989-03-27
IPC分类号： C08F2/00 , C08F257/02 , C08F291/00
CPC分类号： C08F257/02 , C08F291/00
摘要： A process for producing crosslinked polymer particles which comprises a first step of polymerizing a polymerizable monomer containing from 0.1 to 2.0% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in a medium in which the polymerizable monomer is soluble but the resulting polymer is insoluble, to obtain crosslinked polymer particles having a particle size of from 0.8 to 10 .mu.m, and a second step of letting the crosslinked polymer particles absorb from 1 to 50 times by weight of a polymerizable monomer containing from 2 to 100% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in an aqueous medium, followed by polymerization to obtain crosslinked polymer particles having a particle size of from 1 to 30 .mu.m and a crosslinking degree of from 1.0 to 98%.
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