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    Process for producing crosslinked polymer particles
    2.
    发明授权
    Process for producing crosslinked polymer particles 失效

    公开(公告)号：US4906698A

    公开(公告)日：1990-03-06

    申请号：US329279

    申请日：1989-03-27

    申请人： Hiroshi Kusano ,  Hideaki Kiniwa ,  Akihiro Shimura ,  Masahiko Annaka

    发明人： Hiroshi Kusano ,  Hideaki Kiniwa ,  Akihiro Shimura ,  Masahiko Annaka

    IPC分类号： C08F2/00 ,  C08F257/02 ,  C08F291/00

    CPC分类号： C08F257/02 ,  C08F291/00

    摘要： A process for producing crosslinked polymer particles which comprises a first step of polymerizing a polymerizable monomer containing from 0.1 to 2.0% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in a medium in which the polymerizable monomer is soluble but the resulting polymer is insoluble, to obtain crosslinked polymer particles having a particle size of from 0.8 to 10 .mu.m, and a second step of letting the crosslinked polymer particles absorb from 1 to 50 times by weight of a polymerizable monomer containing from 2 to 100% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in an aqueous medium, followed by polymerization to obtain crosslinked polymer particles having a particle size of from 1 to 30 .mu.m and a crosslinking degree of from 1.0 to 98%

    Process for producing crosslinked polymer particles
    3.
    发明授权
    Process for producing crosslinked polymer particles 失效
    制备交联聚合物颗粒的方法

    公开(公告)号：US4908392A

    公开(公告)日：1990-03-13

    申请号：US329289

    申请日：1989-03-27

    申请人： Hiroshi Kusano ,  Hideaki Kiniwa ,  Akihiro Shimura ,  Masahiko Annaka

    发明人： Hiroshi Kusano ,  Hideaki Kiniwa ,  Akihiro Shimura ,  Masahiko Annaka

    IPC分类号： C08F2/00 ,  C08F257/02 ,  C08F291/00

    CPC分类号： C08F257/02 ,  C08F291/00

    摘要： A process for producing crosslinked polymer particles which comprises a first step of polymerizing a polymerizable monomer containing from 0.1 to 2.0% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in a medium in which the polymerizable monomer is soluble but the resulting polymer is insoluble, to obtain crosslinked polymer particles having a particle size of from 0.8 to 10 .mu.m, and a second step of letting the crosslinked polymer particles absorb from 1 to 50 times by weight of a polymerizable monomer containing from 2 to 100% by weight, based on the entire polymerizable monomer, of a crosslinkable monomer in an aqueous medium, followed by polymerization to obtain crosslinked polymer particles having a particle size of from 1 to 30 .mu.m and a crosslinking degree of from 1.0 to 98%.

    OPHTHALMOLOGIC COMPOSITION HAVING GELATION ABILITY
    6.
    发明申请
    OPHTHALMOLOGIC COMPOSITION HAVING GELATION ABILITY 审中-公开
    具有凝胶能力的眼科组合物

    公开(公告)号：US20120070381A1

    公开(公告)日：2012-03-22

    申请号：US13126464

    申请日：2009-10-29

    申请人： Yuichi Yokoyama ,  Toyoaki Matsuura ,  Yoshiaki Hara ,  Masahiko Annaka ,  Kelichi Maruyama ,  Susumu Tanaka

    发明人： Yuichi Yokoyama ,  Toyoaki Matsuura ,  Yoshiaki Hara ,  Masahiko Annaka ,  Kelichi Maruyama ,  Susumu Tanaka

    IPC分类号： A61K49/00 ,  A61F2/14 ,  A61L31/06

    CPC分类号： A61L27/52 ,  A61F2/14 ,  A61F2/141 ,  A61F2/16 ,  A61L2400/06 ,  A61L2430/16

    摘要： Disclosed is a material for use in ophthalmologic organ replacement, which is transparent, has controllable physical properties, and can have physical properties suitable for use as an ophthalmic tissue when the hardness of a gel produced from the material or the fluidability of a sol produced from the material at a specific temperature or lower is varied. Specifically disclosed is an ophthalmologic composition capable of forming a gel, which comprises a polyethylene glycol that is represented by formula 1 and has one end modified with a long-chain alkyl group, a polyethylene glycol that is represented by formula 2 and has both ends modified with a long-chain alkyl group, and a solvent. R1—(CH2CH2O-)n1-R2   (Formula 1) [In formula 1, R1 represents an alkyl group having 1 to 4 carbon atoms; R2 represents an alkyl group having 16 to 22 carbon atoms; and n1 represents the average number of moles of added oxyethylene groups and falls within the range from 45 to 450.] R3—O—(—CH2CH2O-)n2-R4   (Formula 2) [In formula 2, R3 and R4 independently represents an alkyl group having 16 to 22 carbon atoms; and n2 represents average number of moles of added oxyethylene groups and falls within the range from 45 to 450.]

    摘要翻译： 公开了一种用于眼科器官置换的材料，其是透明的，具有可控的物理性质，并且可以具有适合用作眼科组织的物理性质，当由材料产生的凝胶的硬度或由 特定温度以下的材料变化。 具体公开的是能够形成凝胶的眼科组合物，其包含由式1表示并具有一个末端用长链烷基修饰的聚乙二醇，由式2表示并具有两端修饰的聚乙二醇 具有长链烷基和溶剂。 R 1（CH 2 CH 2 O-）n1-R 2（式1）[式1中，R 1表示碳原子数1〜4的烷基， R2代表具有16-22个碳原子的烷基; 并且n1表示加成的氧化乙烯基的平均摩尔数，并且在45〜450的范围内。] R 3 -O - （ - CH 2 CH 2 O-）n 2 -R 4（式2）[式2中，R 3和R 4独立地表示 具有16-22个碳原子的烷基; n2表示加成氧化乙烯基的平均摩尔数，在45〜450的范围内。