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135 条记录 (耗时 0.021 秒)

    3-Hydroxymethylbenzo[b]thiophene derivatives and process for their preparation
    1.
    发明授权
    3-Hydroxymethylbenzo[b]thiophene derivatives and process for their preparation 失效
    3-羟甲基苯并[b]噻吩衍生物及其制备方法

    公开(公告)号：US06774245B2

    公开(公告)日：2004-08-10

    申请号：US10332079

    申请日：2003-01-02

    申请人： Hiroshi Saitoh ,  Tsuyoshi Mizuno ,  Naoki Tsuchiya

    发明人： Hiroshi Saitoh ,  Tsuyoshi Mizuno ,  Naoki Tsuchiya

    IPC分类号： C07D33356

    CPC分类号： C07D333/56

    摘要： The present invention is a method of producing a 3-hydroxymethyl-benzo[b]thiophene derivative without the possible concomitant formation of isomers, which comprises selectively cyclizing a sulfoxide having X shown in the reaction scheme below: wherein R1 to R3 are, same or independently, a hydrogen atom, an alkyl group having 1 to 4 carbons, a trihalomethyl group, an alkoxy group having 1 to 4 carbons, an alkylthio group having 1 to 4 carbons, or a trihalomethoxy group; R4 is an acyl group; X is a halogen atom, a hydroxy group, an amino group, a mercapto group, an alkylthio group having 1 to 9 carbons, an acyloxy group having 1 to 9 carbons, an acylamino group having 1 to 9 carbons, or a trihalomethoxy group.

    摘要翻译： 本发明是一种不含可能伴随形成异构体的3-羟甲基 - 苯并[b]噻吩衍生物的制备方法，该方法包括选择性环化下述反应方案中所示的具有X的亚砜：其中R1至R3相同或相同 独立地为氢原子，碳原子数1〜4的烷基，三卤代甲基，碳原子数1〜4的烷氧基，碳原子数1〜4的烷硫基或三卤甲氧基。 R4是酰基; X是卤素原子，羟基，氨基，巯基，碳原子数1〜9的烷硫基，碳原子数1〜9的酰氧基，碳原子数1〜9的酰氨基或三卤代甲氧基。

    Benzo[b]thiophene derivatives and process for preparing the same
    2.
    发明授权
    Benzo[b]thiophene derivatives and process for preparing the same 失效
    苯并[b]噻吩衍生物及其制备方法

    公开(公告)号：US06884896B2

    公开(公告)日：2005-04-26

    申请号：US10258173

    申请日：2002-02-22

    申请人： Hiroshi Saitoh ,  Naoki Tsuchiya ,  Tsuyoshi Mizuno ,  Tomohide Ida ,  Yoshiyuki Sawai

    发明人： Hiroshi Saitoh ,  Naoki Tsuchiya ,  Tsuyoshi Mizuno ,  Tomohide Ida ,  Yoshiyuki Sawai

    IPC分类号： C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D235/24 ,  C07D333/52

    CPC分类号： C07D333/54 ,  C07D333/56 ,  C07D333/64

    摘要： The present invention is 3,4-disubstituted-benzo[b]thiophene derivatives represented by general formula (I) and processes for preparing compounds represented by general formula (V) from compounds represented by general formula (IV), preparing a mixture of compounds represented by the following formula (II) and the following formula (III) and preparing the benzo[b]thiophene derivatives represented by the above formula (I): wherein, R1 and R2 represent each a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; X represents a hydroxy group or a halogen atom; R3 and R4 represent each a hydrogen or a halogen atom, a trihalomethyl group, a C1-4 alkyl group or a C1-4 alkoxy group; and R5 represents a C1-3 alkyl group or a trifluoromethyl group.

    摘要翻译： 本发明是由通式（I）表示的3,4-二取代 - 苯并[b]噻吩衍生物和由通式（Ⅳ）表示的化合物制备由通式（Ⅴ）表示的化合物的方法，制备化合物 由下式（II）和下式（III）表示并制备由上式（I）表示的苯并[b]噻吩衍生物：其中R 1和R 2 代表卤素原子，三卤代甲基，C 1-4烷基或C 1-4烷氧基; X表示羟基或卤素原子; R 3和R 4各自表示氢或卤素原子，三卤代甲基，C 1-4烷基或C 1-4烷基， C 1-4烷氧基; R 5表示C 1-3烷基或三氟甲基。

    Acid Salt of Benzimidazole Derivative and Crystal Thereof
    4.
    发明申请
    Acid Salt of Benzimidazole Derivative and Crystal Thereof 审中-公开
    苯并咪唑衍生物及其晶体的酸性盐

    公开(公告)号：US20080015240A1

    公开(公告)日：2008-01-17

    申请号：US11667683

    申请日：2005-11-14

    申请人： Mitsuru Teramoto ,  Naoki Tsuchiya ,  Hiroshi Saitoh

    发明人： Mitsuru Teramoto ,  Naoki Tsuchiya ,  Hiroshi Saitoh

    IPC分类号： A61K31/4184 ,  A61P11/00 ,  A61P15/00 ,  A61P29/00 ,  A61P3/00 ,  C07D233/30

    CPC分类号： C07D409/06

    摘要： The present invention provides acid salts, such as sulfate, hydrochloride, and methanesulfonate, of 4-(1-((4-methylbenzothiophen-3-yl)methyl)benzimidazol-2-ylthio)butanoic acid and the crystals thereof. These benzimidazole derivatives and the crystals thereof have an in vivo chymase inhibitory activity and can be used as a preventive or therapeutic agent for inflammatory diseases, allergic diseases, respiratory diseases, circulatory diseases, or bone/cartilage metabolic diseases.

    摘要翻译： 本发明提供4-（1 - （（4-甲基苯并噻吩-3-基）甲基）苯并咪唑-2-基硫基）丁酸的酸式盐，如硫酸盐，盐酸盐和甲磺酸盐及其晶体。 这些苯并咪唑衍生物及其结晶体具有体内糜酶抑制活性，可用作炎性疾病，过敏性疾病，呼吸系统疾病，循环系统疾病或骨/软骨代谢疾病的预防或治疗剂。

    Autorec signal multiplex apparatus, autorec signal multiplex method, program, and recording medium
    7.
    发明授权
    Autorec signal multiplex apparatus, autorec signal multiplex method, program, and recording medium 有权
    自动对准信号多路复用装置，自动对准信号复用方法，程序和记录介质

    公开(公告)号：US07639922B2

    公开(公告)日：2009-12-29

    申请号：US10511831

    申请日：2003-04-14

    申请人： Hiroshi Saitoh ,  Hideaki Mita

    发明人： Hiroshi Saitoh ,  Hideaki Mita

    IPC分类号： H04N5/93 ,  G11B27/00 ,  H04N5/76

    CPC分类号： G11B27/034 ,  G11B27/3027 ,  G11B27/3054 ,  G11B2220/90 ,  H04N5/232 ,  H04N5/77 ,  H04N5/782 ,  H04N5/9201

    摘要： An image pick-up apparatus includes an image pick-up device of recording a video to generate a video signal, a photographer indication device of indicating a start of a recording and/or a stop of the recording, an AutoREC signal generation device of generating an AutoREC signal in conjunction with the start of the recording and/or the stop of the recording based on the indication, and an AutoREC signal multiplex device of multiplexing a generated AutoREC signal to a generated video signal.

    摘要翻译： 图像拾取装置包括：用于记录视频以生成视频信号的图像拾取装置，指示开始记录和/或停止记录的拍摄者指示装置;生成 一个AutoREC信号结合记录的开始和/或基于该指示停止记录;以及一个AutoREC信号多路复用装置，将所生成的AutoREC信号复用到所生成的视频信号。

    Lead frame and package of semiconductor device
    8.
    发明申请
    Lead frame and package of semiconductor device 审中-公开
    引线框和封装的半导体器件

    公开(公告)号：US20090243060A1

    公开(公告)日：2009-10-01

    申请号：US12383915

    申请日：2009-03-26

    申请人： Hiroshi Saitoh

    发明人： Hiroshi Saitoh

    IPC分类号： H01L23/495 ,  H01L23/48

    CPC分类号： H01L23/49861 ,  G01D11/245 ,  G01L19/0069 ,  G01L19/141 ,  G01L19/147 ,  H01L23/055 ,  H01L24/48 ,  H01L24/49 ,  H01L2224/05554 ,  H01L2224/48137 ,  H01L2224/48247 ,  H01L2224/49171 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/1461 ,  H01L2924/181 ,  H01L2924/3025 ,  H03H9/0542 ,  H03H9/1014 ,  H03H9/1071 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

    摘要： A lead frame including a stage and a plurality of terminals is embedded in a mold resin including a base portion for mounting a semiconductor chip (e.g. a microphone chip), a peripheral wall disposed in the periphery of the base portion, and an extension portion extended outside of the peripheral wall, thus forming a package base. A plurality of holes is formed in the peripheral wall so as to expose the internal connection surface of the stage and the internal connection surfaces of the terminals. An extension portion of the stage is exposed on the extension portion of the mold resin in which the surfaces of the terminals are embedded. An extension portion (e.g. a brim) of a cover composed of a conductive material is attached to the extension portion of the mold resin of the package base, thus completely producing a semiconductor device.

    摘要翻译： 将包括台架和多个端子的引线框架嵌入到包括用于安装半导体芯片（例如麦克风芯片）的基座部分的设计树脂中，设置在基部周边的周壁和延伸部分延伸 在周壁外部，从而形成包装基底。 在周壁上形成多个孔，以露出台的内部连接表面和端子的内部连接表面。 台架的延伸部分露出在其中嵌入端子表面的模制树脂的延伸部分上。 由导电材料构成的盖的延伸部分（例如边缘）附接到封装基座的模制树脂的延伸部分，从而完全制造半导体器件。