公开(公告)号：US20100129790A1

公开(公告)日：2010-05-27

申请号：US11884546

申请日：2006-02-16

申请人： Hiroshi Sawada ,  Ikuo Mori ,  Kenji Takami

发明人： Hiroshi Sawada ,  Ikuo Mori ,  Kenji Takami

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： It is intended to provide a rapid, simple and noninvasive novel in vivo method for determining phospholipidosis (PLsis) by detecting a PLsis marker gene. More specifically, it is intended to provide a method for determining phospholipidosis in a mammal comprising the step of detecting change in expression of one or more genes whose expression changes correlated with the onset of phospholipidosis in a sample collected from the mammal, in which at least one of the genes comprises a base sequence identical or substantially identical to the base sequence represented by any of SEQ ID NO: n (wherein n is an odd number between 1 and 57, an integer number between 59 and 63, an even number between 64 and 98, 100 or 101.)

摘要翻译： 旨在提供通过检测PLsis标记基因来测定磷脂病（PLsis）的快速，简单和无创新型体内新方法。 更具体地说，本发明提供一种用于测定哺乳动物中的磷脂病的方法，包括检测从哺乳动物采集的样品中表达变化与磷脂症发生相关的一种或多种基因的表达变化的步骤，其中至少 基因之一包含与SEQ ID NO：n中任一个表示的碱基序列相同或基本相同的碱基序列（其中n为1至57之间的奇数，59至63之间的整数，64之间的偶数 和98,100或101.）

公开(公告)号：US20070218460A1

公开(公告)日：2007-09-20

申请号：US10581008

申请日：2004-11-26

申请人： Kenji Takami ,  Hiroshi Sawada ,  Satoru Asahi

发明人： Kenji Takami ,  Hiroshi Sawada ,  Satoru Asahi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q2600/158 ,  G01N33/5023

摘要： The present invention provides a novel in vitro prediction system of a phospholipidosis inducing potential of a novel drug-caused phospholipidosis marker gene and a drug. Specifically, the invention provides a reagent for prediction of a phospholipidosis inducing potential of a compound containing a nucleic acid capable of detecting the expression of a gene having the same or substantially the same base sequence as the base sequence shown in SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21 or 23. Furthermore, the invention provides a method for predicting a phospholipidosis inducing potential of a compound, which includes detecting the expression of two or more genes showing expression variation in correlation with phospholipidosis expression in a mammalian cell exposed to a test compound.

摘要翻译： 本发明提供一种新型药物引发的磷脂肪酸标记基因和药物的磷脂诱发潜力的体外新体外预测系统。 具体而言，本发明提供了用于预测含有能够检测与SEQ ID NO：1所示的碱基序列具有相同或基本相同碱基序列的基因的表达的核酸的化合物的磷脂抗体诱导电位的试剂， 3，5，7，9，11，13，15，17，19，21或23.此外，本发明提供了一种预测化合物的磷脂抗原诱导电位的方法，其包括检测两种或更多种基因的表达， 在暴露于测试化合物的哺乳动物细胞中与磷脂肪酸表达相关的表达变化。

公开(公告)号：US07799090B2

公开(公告)日：2010-09-21

申请号：US11682501

申请日：2007-03-06

申请人： Kenji Takami ,  Takashi Aoyama ,  Mitsuru Hayashi ,  Takuya Miyagawa ,  Masaya Akutagawa ,  Mitsuhisa Suzuki

发明人： Kenji Takami ,  Takashi Aoyama ,  Mitsuru Hayashi ,  Takuya Miyagawa ,  Masaya Akutagawa ,  Mitsuhisa Suzuki

IPC分类号： A61F2/74

CPC分类号： A61F2/60 ,  A61F2/64 ,  A61F2002/5001 ,  A61F2002/5053 ,  A61F2002/5083 ,  A61F2002/607 ,  A61F2002/608 ,  A61F2002/648 ,  A61F2002/7862 ,  A61F2002/7881

摘要： A modularized prosthesis leg cover quickly covers a prosthesis leg and does not affect bending or stretching motion of a knee joint part of the prosthesis leg, thus preventing damage to the knee joint part of the prosthesis leg. Thus, the modularized prosthesis leg cover includes a thigh module, which can be mounted to a thigh socket of the prosthesis leg, a lower leg module, which can be fastened to a calf pipe of the prosthesis leg, and a patella module, which can be rotatably assembled with the lower leg module. The prosthesis leg cover, which is formed by assembling the modules, is covered with a skin module, which is made of a stretchable fiber. The respective modules are provided as prefabricated modules. A method of manufacturing the prosthesis leg cover is also provided.

摘要翻译： 模块化的假体腿罩快速覆盖假肢腿，并且不影响假肢腿的膝关节部分的弯曲或伸展运动，从而防止对假体腿的膝关节部分的损伤。 因此，模块化的假体腿盖包括大腿模块，其可以安装到假肢腿的大腿插座，可以紧固到假体腿的小腿管的小腿模块和髌骨模块，其可以 与小腿模块可旋转组装。 通过组装模块形成的假体腿罩被由可拉伸纤维制成的皮肤模块覆盖。 相应的模块作为预制模块提供。 还提供了制造假体腿罩的方法。

公开(公告)号：US20070150069A1

公开(公告)日：2007-06-28

申请号：US11682501

申请日：2007-03-06

申请人： Kenji Takami ,  Takashi Aoyama ,  Mitsuru Hayashi ,  Takuya Miyagawa ,  Masaya Akutagawa ,  Mitsuhisa Suzuki

发明人： Kenji Takami ,  Takashi Aoyama ,  Mitsuru Hayashi ,  Takuya Miyagawa ,  Masaya Akutagawa ,  Mitsuhisa Suzuki

IPC分类号： A61F2/74

CPC分类号： A61F2/60 ,  A61F2/64 ,  A61F2002/5001 ,  A61F2002/5053 ,  A61F2002/5083 ,  A61F2002/607 ,  A61F2002/608 ,  A61F2002/648 ,  A61F2002/7862 ,  A61F2002/7881

摘要： The present invention provides a modularized prosthesis leg cover and a method for manufacturing the prosthesis leg cover, which quickly covers a prosthesis leg and does not affect bending or stretching motion of a knee joint part of the prosthesis leg, thus preventing damage to the knee joint part of the prosthesis leg. Thus, the modularized prosthesis leg cover of the present invention includes a thigh module (10), which can be mounted to a thigh socket (2) of the prosthesis leg, a lower leg module (30), which can be fastened to a calf pipe (6) of the prosthesis leg, and a patella module (20), which can be rotatably assembled with the lower leg module (30). The prosthesis leg cover, which is formed by assembling the modules, is covered with a skin module, which is made of a stretchable fiber. The respective modules of the present invention are provided as prefabricated modules.

摘要翻译： 本发明提供了一种模块化的假体腿罩和用于制造假体腿罩的方法，其快速覆盖假肢腿并且不影响假肢腿的膝关节部分的弯曲或拉伸运动，从而防止对膝关节的损伤 假肢的一部分。 因此，本发明的模块化假体腿罩包括可以安装到假体腿的大腿插座（2）的大腿模块（10），可以紧固到小腿的小腿模块（30） 所述假体腿的管（6）以及可与所述小腿模块（30）可旋转地组装的髌骨模块（20）。 通过组装模块形成的假体腿罩被由可拉伸纤维制成的皮肤模块覆盖。 本发明的各个模块作为预制模块提供。

公开(公告)号：US08138123B2

公开(公告)日：2012-03-20

申请号：US12162253

申请日：2007-01-26

申请人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

发明人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

IPC分类号： C40B40/06 ,  C40B60/10 ,  C40B60/12 ,  C07H21/02

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12Q2600/158

摘要： The present invention provides a tool for analysis of expression of Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs:1-14, or partial sequences thereof, and a method of analyzing the expression of Macaca fascicularis gene, including measuring a gene transcription product in a Macaca fascicularis sample using the tool.

摘要翻译： 本发明提供了一种用于分析猕猴猕猴基因表达分析工具的表达的工具，其包含一组核酸，所述核酸含有与两个或更多个碱基序列相同或基本上相同的碱基序列，所述碱基序列选自SEQ ID NO： ID NO：1-14或其部分序列，以及分析猕猴猕猴的基因表达的方法，包括使用该工具测定猕猴属绦虫样品中的基因转录产物。

公开(公告)号：US08535880B2

公开(公告)日：2013-09-17

申请号：US12447446

申请日：2007-10-26

申请人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

发明人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/158 ,  G06F19/20

摘要： The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including: (1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

公开(公告)号：US20090311701A1

公开(公告)日：2009-12-17

申请号：US12447446

申请日：2007-10-26

申请人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

发明人： Saku Miyamoto ,  Kenji Takami ,  Akira Horinouchi

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6876 ,  C12Q1/6881 ,  C12Q2600/158 ,  G06F19/20

摘要： The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including:(1) a step for measuring expression level of a specified gene group for each organ or tissue in 2 or more individuals, (2) a step for acquiring (a) a minimum value of expression levels in a particular organ or tissue in all individuals, and (b) a maximum value of expression levels in other organs and tissues in all individuals, for each gene, and (3) a step for extracting the gene as a gene highly expressed specifically in the particular organ or tissue if the above-described (a)/(b) ratio is larger than 1. By the present invention, truly organ- or tissue-specific genes are extracted.

摘要翻译： 本发明提供一种提取器官或组织特异性高表达基因的方法，包括：（1）测定2个以上个体中各器官或组织的特定基因组的表达水平的步骤，（2） 获得（a）所有个体的特定器官或组织中表达水平的最小值的步骤，和（b）每个基因的所有个体的其他器官和组织中的表达水平的最大值，和（3）a 如果上述（a）/（b）比大于1，则将该基因提取为特异性高度表达于特定器官或组织的基因的步骤。通过本发明，提取真正的器官或组织特异性基因 。

公开(公告)号：US20090048116A1

公开(公告)日：2009-02-19

申请号：US12162253

申请日：2007-01-26

申请人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

发明人： Nobuyuki Miyajima ,  Akira Horinouchi ,  Kenji Takami ,  Ryota Ise

IPC分类号： C40B30/00 ,  C40B40/08

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12Q2600/158

摘要： The present invention provides a tool for analysis of expression of Macaca fascicularis gene.The present invention provides a Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs: 1-14, or partial sequences thereof, and a method of analyzing the expression of Macaca fascicularis gene, including measuring a gene transcription product in a Macaca fascicularis sample using the tool.

摘要翻译： 本发明提供了用于分析猕猴猕猴的基因表达的工具。 本发明提供了一种含有一组含有与SEQ ID NO：1-14所示的碱基序列相同或基本上相同的两个或多个碱基序列的碱基序列的核酸的猕猴属绦虫基因表达分析工具 或其部分序列，以及分析猕猴猕猴碱基因表达的方法，包括使用该工具测定猕猴属绦虫样品中的基因转录产物。

公开(公告)号：US07174780B2

公开(公告)日：2007-02-13

申请号：US10517836

申请日：2003-12-05

申请人： Eiji Akahane ,  Makoto Sakai ,  Kenji Takami

发明人： Eiji Akahane ,  Makoto Sakai ,  Kenji Takami

IPC分类号： G01F23/16

CPC分类号： F02D33/003 ,  F02M37/007 ,  F02M37/0088 ,  G01F17/00 ,  G01F22/02 ,  G01F23/14 ,  G01F23/32

摘要： When air pressure within a first container is less than a predetermined pressure, air is supplied into the first container through a first pipeline by a pressure application unit. Both the volume of the supplied air and a quantity of change in the air pressure within the first container due to the air supply are detected or calculated, and the volume of the liquid fuel within the first container is calculated from both the volume of the supplied air and the quantity of change in the air pressure. When the liquid fuel within a second container is less than a predetermined quantity, a predetermined quantity of liquid fuel is fed from the first container into the second container through a second pipeline by a feed unit, and the volume of the liquid fuel within the first container is calculated based on the number of times that the liquid fuel was fed.

摘要翻译： 当第一容器内的空气压力小于预定压力时，空气通过第一管道由压力施加单元供应到第一容器中。 检测或计算供给的空气的体积和由于空气供应而在第一容器内的空气压力的变化量，并且从供给的第一容器的体积中计算第一容器内的液体燃料的体积 空气和空气压力的变化量。 当第二容器内的液体燃料小于预定量时，预定量的液体燃料通过进料单元通过第二管道从第一容器进入第二容器，并且第一容器内的液体燃料的体积 容器根据供给液体燃料的次数计算。

公开(公告)号：US20050217368A1

公开(公告)日：2005-10-06

申请号：US10517836

申请日：2003-12-05

申请人： Eiji Akahane ,  Makoto Sakai ,  Kenji Takami

发明人： Eiji Akahane ,  Makoto Sakai ,  Kenji Takami

IPC分类号： G01F11/28 ,  B60K15/03 ,  B60K15/077 ,  F02D33/00 ,  F02M37/00 ,  G01F13/00 ,  G01F17/00 ,  G01F22/02 ,  G01F23/14 ,  G01F23/32 ,  G01F23/00

CPC分类号： F02D33/003 ,  F02M37/007 ,  F02M37/0088 ,  G01F17/00 ,  G01F22/02 ,  G01F23/14 ,  G01F23/32

摘要： A measurement system and a measurement method that are capable of accurately measuring liquid fuel stored in a container. When the air pressure within a first container (3) is less than a predetermined pressure, air is supplied into the first container (3) through a first pipeline (13) by a pressure application means (6). Also, both the volume of the supplied air and a quantity of change in the air pressure within the first container (3) due to the air supply are detected or calculated, and the volume of the liquid fuel within the first container (3) is calculated from both the volume of the supplied air and the quantity of change in the air pressure. When the liquid fuel within a second container (4) is less than a predetermined quantity, a predetermined quantity of liquid fuel is fed from the first container (3) into said second container (4) through the second pipeline (12) by a feed means (8), and the volume of the liquid fuel within the first container (3) is calculated based on the number of times that the liquid fuel was fed. Therefore, a liquid fuel quantity supplied from the first container (3) into the second container (4) can be accurately grasped regardless of shape and tilt of the first container (3).

摘要翻译： 能够精确地测量储存在容器中的液体燃料的测量系统和测量方法。 当第一容器（3）内的空气压力小于预定压力时，空气通过第一管道（13）通过压力施加装置（6）供应到第一容器（3）中。 此外，检测或计算供给的空气的体积和由于空气供给而在第一容器（3）内的空气压力的变化量，并且第一容器（3）内的液体燃料的体积为 由供气的体积和空气压力的变化量两者计算。 当第二容器（4）内的液体燃料小于预定量时，预定量的液体燃料通过第二管道（12）通过进料从第一容器（3）进入所述第二容器（4） 装置（8），并且基于供给液体燃料的次数计算第一容器（3）内的液体燃料的体积。 因此，无论第一容器（3）的形状和倾斜如何，都可以精确地掌握从第一容器（3）供给到第二容器（4）中的液体燃料量。