公开(公告)号：US20110160399A1

公开(公告)日：2011-06-30

申请号：US13000950

申请日：2009-07-01

申请人： Hiroki Nagase ,  Hiroshi Sugiyama ,  Tukasa Suzuki ,  Toshikazu Bando ,  Makoto Kimura ,  Akimichi Ohtsuki

发明人： Hiroki Nagase ,  Hiroshi Sugiyama ,  Tukasa Suzuki ,  Toshikazu Bando ,  Makoto Kimura ,  Akimichi Ohtsuki

IPC分类号： C08G69/48

CPC分类号： C07D403/14 ,  A61K45/06 ,  A61K47/595 ,  A61K47/60 ,  A61K47/62

摘要： The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator.

摘要翻译： 本发明提供了靶基因特异性组蛋白修饰调节剂，其包含组蛋白修饰调节剂和能够识别靶基因中调节区的聚酰胺之间的缀合物。 这使得能够提供靶基因特异性组蛋白修饰调节剂。

公开(公告)号：US07456294B2

公开(公告)日：2008-11-25

申请号：US10507004

申请日：2003-03-03

申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

IPC分类号： A61K31/407 ,  C07D403/14

CPC分类号： C07D487/04 ,  C07D403/14

摘要： It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.

摘要翻译： 旨在提供一种吡咯 - 咪唑聚酰胺型功能分子，其与DNA上存在的特定碱基序列相比，具有增强的DNA烷基化能力和识别序列，与此类型的现有功能分子相比。 在吡咯 - 咪唑聚酰胺末端通过乙烯基接头具有烷基化位点的发夹聚酰胺。 用于抑制特定基因表达的药物和含有上述发夹聚酰胺的抗癌剂。

公开(公告)号：US07745473B2

公开(公告)日：2010-06-29

申请号：US10598789

申请日：2005-03-10

申请人： Hiroshi Sugiyama ,  Toshikazu Bando

发明人： Hiroshi Sugiyama ,  Toshikazu Bando

IPC分类号： A61K31/7052 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/405 ,  C07D403/14 ,  C07D233/54 ,  C07D233/06

CPC分类号： C07D403/14 ,  C07D487/04

摘要： There is provided a novel pyrrole-imidazole polyamide compound for alkylating the specific base sequence of DNA, the polyamide compound being capable of being synthesized through fewer reaction steps than known hybrid molecules and having a combination of a high reactivity in DNA alkylation and the ability to recognize a sequence. Furthermore, there is provided an alkylating agent and a molecule serving as a drug, the alkylating agent and the molecule containing the polyamide compound.An indole derivative is represented by general formula (1): wherein R1 represents a functional group for alkylating DNA; R2 represents a hydrogen atom, an alkyl group, or an acyl group; and X represents a divalent group having one constitutional unit or having two or more constitutional units which may be the same or different, the constitutional unit being represented by the following formula: (wherein m is an integer of 0 to 10), wherein among the constitutional units, a terminal constitutional unit adjacent to R2 may be a constitutional unit represented by the following formula: (wherein k is an integer of 0 to 10).

摘要翻译： 提供了一种用于烷基化DNA特异性碱基序列的新型吡咯 - 咪唑聚酰胺化合物，该聚酰胺化合物能够通过比已知杂化分子更少的反应步骤合成，并且具有DNA烷基化反应性高的能力和 识别序列。 此外，提供烷基化剂和作为药物的分子，烷基化剂和含有聚酰胺化合物的分子。 吲哚衍生物由通式（1）表示：其中R1表示用于烷基化DNA的官能团; R2表示氢原子，烷基或酰基; X表示具有一个结构单元或具有两个或更多个可以相同或不同的结构单元的二价基团，其结构单元由下式表示：（其中m为0至10的整数），其中 结构单元，与R2相邻的末端结构单元可以是由下式表示的结构单元：（其中k是0〜10的整数）。

公开(公告)号：US20070191260A1

公开(公告)日：2007-08-16

申请号：US10598789

申请日：2005-03-10

申请人： Hiroshi Sugiyama ,  Toshikazu Bando

发明人： Hiroshi Sugiyama ,  Toshikazu Bando

IPC分类号： A61K38/04 ,  A61K31/7052 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/405 ,  C07D403/14

CPC分类号： C07D403/14 ,  C07D487/04

摘要： There is provided a novel pyrrole-imidazole polyamide compound for alkylating the specific base sequence of DNA, the polyamide compound being capable of being synthesized through fewer reaction steps than known hybrid molecules and having a combination of a high reactivity in DNA alkylation and the ability to recognize a sequence. Furthermore, there is provided an alkylating agent and a molecule serving as a drug, the alkylating agent and the molecule containing the polyamide compound. An indole derivative is represented by general formula (1): wherein R1 represents a functional group for alkylating DNA; R2 represents a hydrogen atom, an alkyl group, or an acyl group; and X represents a divalent group having one constitutional unit or having two or more constitutional units which may be the same or different, the constitutional unit being represented by the following formula: (wherein m is an integer of 0 to 10), wherein among the constitutional units, a terminal constitutional unit adjacent to R2 may be a constitutional unit represented by the following formula: (wherein k is an integer of 0 to 10).

摘要翻译： 提供了一种用于烷基化DNA特异性碱基序列的新型吡咯 - 咪唑聚酰胺化合物，该聚酰胺化合物能够通过比已知杂化分子更少的反应步骤合成，并且具有DNA烷基化反应性高的能力和 识别序列。 此外，提供烷基化剂和作为药物的分子，烷基化剂和含有聚酰胺化合物的分子。 吲哚衍生物由通式（1）表示：其中R 1表示用于烷基化DNA的官能团; R 2表示氢原子，烷基或酰基; X表示具有一个结构单元或具有两个或更多个可以相同或不同的结构单元的二价基团，其结构单元由下式表示：（其中m为0至10的整数），其中 结构单元，与R 2相邻的末端结构单元可以是由下式表示的结构单元：（其中k是0至10的整数）。

公开(公告)号：US20050176647A1

公开(公告)日：2005-08-11

申请号：US10507004

申请日：2003-03-03

申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Isao Saito

IPC分类号： C12N15/09 ,  A61K31/4178 ,  A61P35/00 ,  A61P43/00 ,  C07D233/90 ,  C07D403/14 ,  C07D487/04 ,  C07D487/10 ,  A61K38/08 ,  C07K7/06 ,  C07D43/14

CPC分类号： C07D487/04 ,  C07D403/14

摘要： It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.

摘要翻译： 旨在提供一种吡咯 - 咪唑聚酰胺型功能分子，其与DNA上存在的特定碱基序列相比，具有增强的DNA烷基化能力和识别序列，与此类型的现有功能分子相比。 在吡咯 - 咪唑聚酰胺末端通过乙烯基接头具有烷基化位点的发夹聚酰胺。 用于抑制特定基因表达的药物和含有上述发夹聚酰胺的抗癌剂。

公开(公告)号：US06946455B2

公开(公告)日：2005-09-20

申请号：US10030678

申请日：2001-05-01

申请人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Toshikazu Bando ,  Hirokazu Iida ,  Isao Saito

IPC分类号： C12N15/00 ,  A61K31/407 ,  A61P35/00 ,  C07D487/04 ,  C07D487/10 ,  C07D519/00 ,  C12N15/01 ,  C12N15/09 ,  A61K31/33 ,  A01N43/38 ,  A01N43/90 ,  A61K31/44 ,  C07D209/56

CPC分类号： C07D487/04 ,  C07D487/10

摘要： Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked: A-L-B-X-B-L-A  (I) wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.

摘要翻译： 由通式（I）表示的化合物：两个DNA链可以是交联的：<？in-line-formula description =“In-line Formulas”end =“lead”？> ALBXBLA（I） line-formula description =“In-line Formulas”end =“tail”？>其中B表示能识别DNA核苷酸序列的化学结构; A表示能够结合DNA的一个碱基的化学结构; L表示A和B的化学结构可以彼此连接的连接体; X表示可以将A-L-B成分彼此连接的间隔物。 通过使用这些化合物进行链间交联DNA的方法; 以及含有星际交联剂的DNA的药物组合物。

公开(公告)号：US20090240496A1

公开(公告)日：2009-09-24

申请号：US12404505

申请日：2009-03-16

申请人： Daisuke Yamamoto ,  Hiroshi Sugiyama ,  Toshiyuki Koga ,  Kaoru Suzuki

发明人： Daisuke Yamamoto ,  Hiroshi Sugiyama ,  Toshiyuki Koga ,  Kaoru Suzuki

IPC分类号： G10L15/20 ,  G10L15/00

CPC分类号： G10L15/20 ,  G10L21/0208 ,  G10L25/78

摘要： According to one aspect of the invention, a speech recognizer includes: an audio data acquiring portion configured to acquire audio data via a microphone; a speech section detecting portion configured to detect a talking start time and a talking end time based on the audio data; a spoken word identifying portion configured to identify the audio in a speech section from the talking start time to the talking end time; and a noise suppressing portion configured to suppress a generation of a noise from an electrical noise source for the speech section.

摘要翻译： 根据本发明的一个方面，语音识别器包括：音频数据获取部分，经配置以通过麦克风获取音频数据; 语音部分检测部分，被配置为基于音频数据检测通话开始时间和通话结束时间; 口语单词识别部分，被配置为从通话开始时间到通话结束时间识别话音部分中的音频; 以及噪声抑制部，被配置为抑制来自语音部分的电噪声源的噪声的产生。

公开(公告)号：US20080170653A1

公开(公告)日：2008-07-17

申请号：US11885069

申请日：2006-02-28

申请人： Masami Ando ,  Anton Maksimenko ,  Hiroshi Sugiyama ,  Tetsuya Yuasa

发明人： Masami Ando ,  Anton Maksimenko ,  Hiroshi Sugiyama ,  Tetsuya Yuasa

IPC分类号： G01N23/04 ,  G06K9/00

CPC分类号： A61B6/466 ,  A61B6/4092 ,  A61B6/483 ,  A61B6/502 ,  G01N23/04

摘要： A method and apparatus for constructing a 3-dimensional image of the internal organs invisible by the conventional method is provided. The apparatus comprises: generating means for generating a monochromatic and parallel X-ray beam from an X-ray beam; a reflection-type angle analyzer for reflecting the monochromatic and parallel X-ray beam at reflecting points on both slopes of a reflection curve of the reflection-type analyzer, angle information being extracted to a maximum extent at the reflecting points, the monochromatic and parallel X-ray beam including an X-ray beam which passed through the object when the object is positioned on a rotatable goniometer in the monochromatic and parallel X-ray beam and an X-ray beam from the generating means when the object is not positioned in the monochromatic and parallel X-ray beam; an imaging device for generating a refraction angle data by receiving the monochromic and parallel X-ray beam reflected on the reflection-type angle analyzer to detect the intensity thereof, and output a refraction angle data; andan arithmetic device for constructing the 3-dimensional image by carrying out au arithmetical operation for the refraction angle data from the imaging device.

摘要翻译： 提供了一种通过常规方法构建不可见的内脏的三维图像的方法和装置。 该装置包括：用于从X射线束产生单色和平行X射线束的产生装置; 反射型角度分析仪，用于在反射型分析仪的反射曲线的两个斜率上的反射点处反射单色平行X射线束，在反射点最大程度地提取角度信息，单色和平行 X射线束包括当物体位于单色和平行X射线束中的可旋转角度计上时穿过物体的X射线束，以及当物体未定位在来自发生装置的X射线束时 单色和平行的X射线束; 用于通过接收在反射型角度分析仪上反射的单色和平行X射线束来产生折射角数据以检测其强度并输出折射角数据的成像装置; 以及用于通过对来自成像装置的折射角数据执行自动运算来构造3维图像的运算装置。

公开(公告)号：US20060075021A1

公开(公告)日：2006-04-06

申请号：US11294435

申请日：2005-12-06

申请人： Hiroshi Sugiyama ,  Miwako Doi

发明人： Hiroshi Sugiyama ,  Miwako Doi

IPC分类号： G06F15/16

CPC分类号： H04B1/20

摘要： There is disclosed an information exchange apparatus in which apparatus name information and address information of a display/headphone are transferred to a DVD reproduction apparatus from the display/headphone via a path of an infrared ray or the like different from a radio path for exchanging information. The information are registered in the DVD reproduction apparatus. The DVD reproduction apparatus on a transmission side transmits video and audio information based on information concerning the display/headphone as a reception side registered in the reproduction apparatus, and the display/headphone on the reception side receives the video and audio information transmitted to the display/headphone.

公开(公告)号：US06729711B1

公开(公告)日：2004-05-04

申请号：US09565446

申请日：2000-05-05

申请人： Kenichiro Hashimoto ,  Jiro Moriyama ,  Hiroshi Sugiyama ,  Isao Ebisawa ,  Hisao Yaegashi ,  Toshiharu Inui

发明人： Kenichiro Hashimoto ,  Jiro Moriyama ,  Hiroshi Sugiyama ,  Isao Ebisawa ,  Hisao Yaegashi ,  Toshiharu Inui

IPC分类号： B41J29393

CPC分类号： B41J29/38 ,  B41J2/17503 ,  B41J2/17546 ,  B41J2/17566 ,  B41J25/34 ,  B41J2002/17573 ,  B41J2002/17576

摘要： An ink jet recording apparatus comprises a carriage movable in a given direction with a recording head which is detachably mountable on it and provided with discharge ports for discharging liquid. The apparatus is arranged to include a sensor for detecting the presence or absence of the carriage, the recording head, and at least one of the ink containers. This sensor is provided for the main body of the apparatus and positioned within the movable range of the carriage. With this arrangement, it is possible to simplify the structure required for detecting whether or not these vital elements for recording are installed without any auxiliary power-supply or memory means.

摘要翻译： 一种喷墨记录装置，包括可沿着给定方向移动的托架，其具有可拆卸地安装在其上并具有用于排出液体的排出口的记录头。 该装置被布置成包括用于检测托架，记录头和至少一个墨盒的传感器。 该传感器设置在设备的主体上，并位于滑架的可移动范围内。 利用这种布置，可以简化检测这些用于记录的这些重要元件是否安装在没有任何辅助电源或存储装置的情况下所需的结构。