摘要:
The present invention examined the accumulation of chondroitin sulfate proteoglycans (CSPGs). The present invention relates to neurodegeneration-suppressing agents that are suitable for gene therapy or prevention of neural fibrotic degenerative diseases which induce neural cell death due to an accumulation of abnormal proteins, where the therapies are based on siRNAs against N-acetylgalactosamine-4-O-sulfotransferases (N-acetylgalactosamine-4-O-sulfotransferase-1, N-acetylgalactosamine-4-O-sulfotransferase-2, and N-acetylgalactosamine-4-sulfate 6-O-sulfotransferase (GalNAc4ST-1, GalNAc4ST-2, and GALNAC4S-6ST, respectively)), which are sulfotransferases for acetylgalactosamine, a CSPG side chain, and chondroitinase ABC, an enzyme that degrades chondroitin sulfate, another CSPG side chain.
摘要翻译:本发明检测了硫酸软骨素蛋白聚糖(CSPG)的积累。 本发明涉及适用于基因治疗或预防由于异常蛋白质积累引起神经细胞死亡的神经纤维变性疾病的神经变性抑制剂,其中所述疗法基于针对N-乙酰半乳糖胺-4- O的siRNA - 转氨酶(N-乙酰半乳糖胺-4- O - 磺基转移酶-1,N-乙酰半乳糖胺-4- -O-磺基转移酶-2和N-乙酰半乳糖胺-4-硫酸酯6-O-磺基转移酶(GalNAc4ST-1,GalNAc4ST-2和 分别为GALNAC4S-6ST)),其为乙酰半乳糖胺磺酸转移酶,CSPG侧链和软骨素酶ABC,其是降解硫酸软骨素,另一CSPG侧链的酶。
摘要:
A drowsiness detector detects the drowsiness by measuring a distance of an eyebrow at three points from a reference line defined by an inner eye corner and an outer eye corner. The three distances of the eyebrow from the reference line are respectively standardized by an inter-eye distance between the inner eye corners of the left and right eyes, and are respectively compared with thresholds for determining the rise of the eyebrow. The rise of the eyebrow is then translated as the start of the drowsiness, and is associated with an operation such as a doze prevention operation or the like.
摘要:
A performance processing apparatus is operable by user with aide of control and sound devices for providing sample music data to data management apparatus. A storage section stores original music data representing a music piece composed of tones. An acquisition section acquires input information from control device which has a detector for detecting either physical action or physiological state of user and operated by user to provide input information indicating detection result by detector. A processing section controls a performance parameter according to input information for enabling sound device to generate tones of the music piece represented by original music data and altered by user. A transmitting section transmits sample music data representing music piece composed of tones controlled by the performance parameter to the data management apparatus which has a storage device for storing sample music data for use as a material of evaluating mental or physical function of user.
摘要:
A totally new method for manufacturing a thin film wherein only an arbitrary small region is structurally controlled. The structure of a film is controlled by applying a force to the entire film or an arbitrary region of the film using a part having a sharp tip during the film-forming process or after finishing the film formation. At this time, the temperature of the film is set at the glass transition point of the amorphous region or higher. An atomic force microscope can be used as an apparatus for realizing this manufacturing method.
摘要:
A recycling method which comprises constructing a membership computer system comprising appending to products identification displays showing that the products satisfy the standards for products scarcely giving loads to environments, easily recyclable products, highly healthy and safe products, or the like, connecting members comprising the producers A of the products to which the identification displays can be appended, product seller B, purchasers or consumers C, waste-collecting members D, collected commodity-transporting members E, and intermediate raw material producers F to an information network manager G through an information network, and totally monitoring and managing the production of the products, sales, wastes and the production of the intermediate raw materials by the information network manager G, and recycling the used products as wastes to the intermediate raw materials for producing the products, and by which the products can be produced with reduced energy, and the system thereof.
摘要:
An ignition system for an internal combustion engine. At least one of a plurality of spark plugs 4 and 5 attached to each of cylinders 2A, 2B, 3B, and 3A is a self-cleaning spark plug A.
摘要:
Disclosed is a solid photographic processing composition for developing a silver halide photographic light-sensitive material comprising a ferric complex of an aminopolycarboxylic acid and a sugar alcohol compound.
摘要:
A projection-type image display device includes: a light source; a display element that displays an image based on an input video signal; a trapezoidal distortion correction unit that performs pixel conversion in which pixel data of the input video signal are compressed or interpolated and supplies the display element with the corrected signal that includes a first video signal that is the video signal concerning which the pixel conversion has been carried out; a detection unit that detects the luminance distribution of the first video signal; and an adjustment unit that adjusts the light quantity of the light source based on the detected luminance distribution data.