-
1.
公开(公告)号:US20200182751A1
公开(公告)日:2020-06-11
申请号:US16707552
申请日:2019-12-09
Applicant: Hitachi, Ltd.
Inventor: Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Akihiro NOJIMA , Shunsuke KONO
Abstract: Please substitute the new Abstract set forth below for the original Abstract: The object of the invention is to perform, rapidly and at a low cost, a pretreatment of an analysis sample containing a turbid substance. Provided is an analysis sample pretreatment apparatus in which a clarified liquid is obtained by removing a turbid substance from an analysis sample. The analysis sample pretreatment apparatus includes a cell configured to store the analysis sample, and a cell holder in which at least a part of a housing is opened to mount the cell. The cell holder includes an ultrasonic wave transducer and an ultrasonic wave reflection plate that are disposed on facing plane pairs while sandwiching the cell mounted inside the cell holder. The cell includes a first opening unit from which the analysis sample flows in, a second opening unit from which the clarified liquid flows out, and a third opening unit from which the turbid substance is discharged. In a state where the cell is mounted in the cell holder, the first opening unit is provided at a position lower than an upper end of the ultrasonic wave transducer in a vertical direction, or at a position higher than a lower end of the ultrasonic wave transducer in the vertical direction.
-
公开(公告)号:US20240038524A1
公开(公告)日:2024-02-01
申请号:US18213974
申请日:2023-06-26
Applicant: HITACHI, LTD.
Inventor: Masuyuki SUGIYAMA , Shun KUMANO , Akihiro NOJIMA
CPC classification number: H01J49/4225 , H01J49/065 , H01J49/429 , H01J49/0031
Abstract: The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.
-
公开(公告)号:US20180172584A1
公开(公告)日:2018-06-21
申请号:US15833075
申请日:2017-12-06
Applicant: Hitachi, Ltd.
Inventor: Takuya KANBAYASHI , Shinichi TANIGUCHI , Akihiro NOJIMA , Yusuke KAGA
CPC classification number: G01N21/534 , G01N21/01 , G01N21/1717 , G01N2021/1729 , G01N2201/023
Abstract: The invention optically analyzes a component in a sample having a material suspended. An optical analysis system that irradiates a liquid sample with light and analyzes a component of the sample using transmitted light transmitted through the sample includes a container accommodating the sample and an ultrasonic irradiation unit irradiating an ultrasonic wave for exciting the sample. The container includes a pair of light transmission wall portions between which the sample is disposed and which has light transmissivity, and one of the light transmission wall portions and the other of the light transmission wall portions are disposed to be separated from each other at a distance shorter than a wavelength of the ultrasonic wave.
-
公开(公告)号:US20220317023A1
公开(公告)日:2022-10-06
申请号:US17596051
申请日:2020-03-19
Applicant: Hitachi, Ltd.
Inventor: Takuya KAMBAYASHI , Toshimitsu NOGUCHI , Shunsuke KONO , Akihiro NOJIMA
Abstract: An arithmetic expression used for estimating a target item of a specimen is more easily incorporated into an optical measurement system. An optical measurement instrument includes an optical analysis unit configured to perform an optical analysis on a specimen and measure an intensity of light as a result of the optical analysis, and an arithmetic processing unit configured to download an arithmetic expression from a server device via a network, and perform a quantitative analysis on a target substance contained in the specimen by substituting the result of the optical analysis by the optical analysis unit into the arithmetic expression.
-
公开(公告)号:US20180224374A1
公开(公告)日:2018-08-09
申请号:US15884231
申请日:2018-01-30
Applicant: Hitachi, Ltd.
Inventor: Takuya KANBAYASHI , Shinichi TANIGUCHI , Akihiro NOJIMA
CPC classification number: G01N21/59 , G01N1/28 , G01N21/0303 , G01N21/534 , G01N2021/036
Abstract: An optical analysis apparatus, that irradiates a liquid sample with light and analyzes the sample, includes a measurement unit that measures the sample, a light source portion that emits light with which the sample is irradiated, and a light receiving portion that receives the light transmitted through the sample. The measurement unit includes a housing provided with an opening portion for flowing in and out of the sample, an accommodation region connected to the opening portion and provided inside the housing, a movable portion provided inside the accommodation region to be movable inside the accommodation region, an irradiation portion which receives the light emitted from the light source portion and in which an inside of the accommodation region is irradiated with the light, and a light collection portion which collects the light transmitted through the sample inside the accommodation region and outputs the light to the light receiving portion.
-
公开(公告)号:US20250076306A1
公开(公告)日:2025-03-06
申请号:US18791705
申请日:2024-08-01
Applicant: HITACHI, LTD. , ARCALIS, Inc.
Inventor: Shun KUMANO , Akihiro NOJIMA , Masuyuki SUGIYAMA , Rena AKAHORI , Shoko KAWAKAMI
IPC: G01N33/68 , C12Q1/37 , C12Q1/6806 , C12Q1/6816 , C12Q1/6844
Abstract: There is provided a method for optimizing a nucleic acid sequence, including the steps of: preparing a nucleic acid sequence that includes a candidate sequence containing a sequence of an untranslated region and a sequence encoding a target protein, and a sequence encoding a peptide barcode directly or indirectly linked to the target protein; expressing a protein from the nucleic acid sequence; separating the peptide barcode from the protein; analyzing the separated peptide barcode; and acquiring a relationship between expression of the target protein and the candidate sequence based on a result of the analysis, and selecting an optimal candidate sequence.
-
公开(公告)号:US20220178817A1
公开(公告)日:2022-06-09
申请号:US17593983
申请日:2020-03-18
Applicant: Hitachi, Ltd.
Inventor: Toshimitsu NOGUCHI , Takuya KAMBAYASHI , Shunsuke KONO , Akihiro NOJIMA
Abstract: An object of the invention is to provide an optical analysis method and an optical analysis system capable of accurately performing an optical analysis by using transmitted light even though a sample contains a turbid substance. The optical analysis method of the present disclosure is an optical analysis method for irradiating a sample s containing a turbid substance in a cell 11 with light and performing optical analysis on the sample s by using transmitted light of the light. The optical analysis method includes: exciting the sample s in the cell 11 by irradiation with ultrasonic waves while adjusting a frequency of the ultrasonic waves such that an intensity of the transmitted light is maximized, and then performing the optical analysis in a state where the sample s is irradiated with ultrasonic waves of this adjusted frequency.
-
8.
公开(公告)号:US20200291341A1
公开(公告)日:2020-09-17
申请号:US16774048
申请日:2020-01-28
Applicant: HITACHI, LTD.
Inventor: Shunsuke KONO , Takuya KAMBAYASHI , Toshimitsu NOGUCHI , Akihiro NOJIMA
Abstract: Human labor and time can be reduced, and a high-accuracy numerical model can be created. Provided is a pseudo sample creation method including mixing a pre-culture liquid medium that is not used to culture a sample, a post-culture liquid medium that is used to culture the sample, and an additive containing at least one of saccharides, an amino acid, a metabolite, and protein with one another to create a pseudo sample. In addition, provided is a numerical model creation system including: a spectrometer that acquires spectral data of a pseudo sample; a reference value measuring device that measures a reference value of the pseudo sample; and an analyzer that creates a numerical model representing a correlation between the spectral data and the reference value based on the spectral data and the reference values obtained from a plurality of pseudo samples.
-
-
-
-
-
-
-