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公开(公告)号：US20140295430A1
公开(公告)日：2014-10-02
申请号：US14349520
申请日：2012-10-04
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6834 , C12Q1/6804 , C12Q1/6837 , G01N21/6428 , G01N21/6452 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/587 , G01N2021/6421 , C12Q2525/161 , C12Q2545/114 , C12Q2563/107 , C12Q2563/143 , C12Q2563/149 , C12Q2565/514 , C12Q2563/119
摘要： The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic microparticles are used in the present invention, the number of biomolecules can be counted, and since hybridization and an antigen-antibody reaction are performed with the microparticles having biomolecules immobilized thereon dispersed, the reaction can be rapidly performed. Further, the type and the abundance of biomolecules of interest can be determined at a single molecular level, so as to evaluate, in particular, the absolute concentration of biomolecules.
摘要翻译： 分析生物分子的方法包括以下步骤：将待分析的生物分子固定在磁性微粒的表面上; 使标记的探针分子与待分析的生物分子反应; 将微粒收集并固定在支撑基底上; 并测量支撑衬底上的标签。 由于在本发明中使用单分子固定化磁性微粒，因此可以计数生物分子的数量，由于在其上分散固定有生物分子的微粒进行杂交和抗原 - 抗体反应，所以可以快速进行反应。 此外，感兴趣的生物分子的类型和丰度可以在单个分子水平上确定，以便特别地评估生物分子的绝对浓度。
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公开(公告)号：US20130287629A1
公开(公告)日：2013-10-31
申请号：US13927209
申请日：2013-06-26
发明人： Isao Yamazaki , Ryuji Tao , Katsuaki Takahashi
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , G01N35/0092 , G01N35/025 , G01N35/1002 , G01N35/1083 , G01N2035/0094 , G01N2035/1076 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/116664 , Y10T436/119163 , Y10T436/12
摘要： An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.
摘要翻译： 根据本发明的自动分析仪是紧凑的，安装大量试剂，具有高处理能力。 试剂盘布置在反应盘的内部和外部。 试剂探针可以将试剂注入到两个试剂盘的共同位置的位置。 多个试剂探针之一在一个循环中接近一个试剂盘。 多个试剂探针交替接近试剂盘。 因此，可以将第一试剂和第二试剂置于两个试剂盘上。 可以在不扩大分析仪的情况下增加试剂的安装数量。 可以缩短循环时间，使自动分析仪具有较高的处理能力。
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公开(公告)号：US09822399B2
公开(公告)日：2017-11-21
申请号：US14349520
申请日：2012-10-04
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/68 , G01N21/64 , G01N33/543 , G01N33/58
CPC分类号： C12Q1/6834 , C12Q1/6804 , C12Q1/6837 , G01N21/6428 , G01N21/6452 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/587 , G01N2021/6421 , C12Q2525/161 , C12Q2545/114 , C12Q2563/107 , C12Q2563/143 , C12Q2563/149 , C12Q2565/514 , C12Q2563/119
摘要： The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic microparticles are used in the present invention, the number of biomolecules can be counted, and since hybridization and an antigen-antibody reaction are performed with the microparticles having biomolecules immobilized thereon dispersed, the reaction can be rapidly performed. Further, the type and the abundance of biomolecules of interest can be determined at a single molecular level, so as to evaluate, in particular, the absolute concentration of biomolecules.
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公开(公告)号：US08632725B2
公开(公告)日：2014-01-21
申请号：US13927209
申请日：2013-06-26
发明人： Isao Yamazaki , Ryuji Tao , Katsuaki Takahashi
CPC分类号： G01N21/75 , G01N35/0092 , G01N35/025 , G01N35/1002 , G01N35/1083 , G01N2035/0094 , G01N2035/1076 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/116664 , Y10T436/119163 , Y10T436/12
摘要： An automatic analyzer according to the present invention is compact, mounting great number of reagents, having high processing ability. Reagent disks are arranged at inside and outside of a reaction disk. A reagent probe can inject a reagent into the position which is common position of both reagent disks. One of plural reagent probes approaches to one of reagent disks at one cycle. Plural reagent probes alternatively approach to the reagent disk. Therefore, the first reagents and the second reagents can be placed on both reagent disks. The mounting number of reagents can be increased without enlarging an analyzer. The cycle time can be shortened to make an automatic analyzer to have high processing ability.
摘要翻译： 根据本发明的自动分析仪是紧凑的，安装大量试剂，具有高处理能力。 试剂盘布置在反应盘的内部和外部。 试剂探针可以将试剂注入到两个试剂盘的共同位置的位置。 多个试剂探针之一在一个循环中接近一个试剂盘。 多个试剂探针交替接近试剂盘。 因此，可以将第一试剂和第二试剂置于两个试剂盘上。 可以在不扩大分析仪的情况下增加试剂的安装数量。 可以缩短循环时间，使自动分析仪具有较高的处理能力。
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