公开(公告)号：US11656219B2

公开(公告)日：2023-05-23

申请号：US16624265

申请日：2017-07-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kazuma Matsui ,  Michiru Fujioka ,  Yusuke Goto

IPC: G01N33/487 ,  C12Q1/6869 ,  B82Y5/00

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N33/48785 ,  B82Y5/00 ,  C12Q2565/631

Abstract: An apparatus for storing a thin film device, the apparatus including: a thin film device 3 having an insulating thin film containing Si and having a thickness of 100 nm or less; a solution in contact with the thin film; and a container having a tank that seals the solution, wherein the solution is a solution that satisfies any of the following conditions (1) to (3).



(1) A solution containing water in a volume ratio of 0% or more to 30% or less
(2) A solution cooled and maintained at a temperature equal to or higher than a solidification point and lower than 15° C.
(3) A solution that contains a salt with a concentration of 1 mol/L or more and a saturation concentration or less and is cooled and maintained to a temperature equal to or higher than a solidification point and lower than 25° C.

公开(公告)号：US10828861B2

公开(公告)日：2020-11-10

申请号：US15968061

申请日：2018-05-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yusuke Goto ,  Masao Kamahori ,  Hiroshi Sasaki ,  Kiyotoshi Mori ,  Hideyuki Akiyama

IPC: B32B1/08 ,  G01N21/05 ,  B32B17/06 ,  B01L3/00 ,  B29C65/46 ,  B29C65/48 ,  B32B7/12 ,  B32B27/28 ,  B32B27/34 ,  B32B27/36 ,  C09J5/06 ,  B29C65/00 ,  B29K71/00 ,  B29L23/00 ,  B29L31/00

Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.

公开(公告)号：US10996211B2

公开(公告)日：2021-05-04

申请号：US15777326

申请日：2016-10-20

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yusuke Goto ,  Takahide Yokoi

IPC: G01N33/487 ,  G01N27/447 ,  G01N33/483 ,  G01N15/10

Abstract: An object of the present invention is to solve inhibition of biopolymer measurement in a nanopore, which involves three-dimensional conformation of a biopolymer containing a nucleic acid. The present invention provides a device for analyzing a biopolymer containing a nucleic acid, the device including: an array device including a plurality of thin film parts having a nanopore; a single common container and a plurality of individual containers capable of storing a measurement solution which is brought into contact with the thin films; and individual electrodes respectively provided in the plurality of individual containers, wherein: the measurement solution is introduced into each of the individual containers and the common container so as to be brought into contact with the thin films; and the measurement solution has a pH equal to or greater than pKa of a guanine base and contains cesium ions as electrolyte cations.

公开(公告)号：US09885683B2

公开(公告)日：2018-02-06

申请号：US15021400

申请日：2014-07-28

Applicant: Hitachi High-Technologies Corporation

Inventor： Yu Ishige ,  Masao Kamahori ,  Tetsuyoshi Ono ,  Yusuke Goto

IPC: G01N27/333 ,  G01N27/30

CPC classification number: G01N27/3335 ,  G01N27/308 ,  G01N27/333

Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.

公开(公告)号：US11474065B2

公开(公告)日：2022-10-18

申请号：US16304517

申请日：2017-04-11

Applicant: Hitachi High-Technologies Corporation

Inventor： Yoshimitsu Yanagawa ,  Yusuke Goto ,  Michiru Fujioka

IPC: C12M1/00 ,  G01N27/22 ,  C12Q1/68 ,  G01N27/00 ,  C12Q1/6869

Abstract: An object of the present invention is to provide a biomolecule measuring device that can decrease the influence of crosstalk between chambers. A biomolecule measuring device according to the present invention supplies, to electrodes equipped on chambers, voltages modulated differently to each other.

公开(公告)号：US11448638B2

公开(公告)日：2022-09-20

申请号：US16476860

申请日：2017-01-10

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kazuma Matsui ,  Yusuke Goto ,  Rena Akahori ,  Takahide Yokoi ,  Michiru Fujioka

IPC: G01N33/487 ,  G01N27/447

Abstract: Provided are a first tank; a second tank; a thin film having a nanopore, which communicates the first tank to the second tank, and disposed between the first and second tanks; a first electrode provided in the first tank; and a second electrode provided in the second tank. A wall surface of the nanopore has an ion adsorption preventing structure to prevent desorption/adsorption of an ion contained in a solution filling the first tank and/or the second tank, and a voltage is applied between the first and second electrodes to measure an ion current flowing through the nanopore.

公开(公告)号：US11007747B2

公开(公告)日：2021-05-18

申请号：US15968048

申请日：2018-05-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yusuke Goto ,  Masao Kamahori ,  Hiroshi Sasaki ,  Kiyotoshi Mori ,  Hideyuki Akiyama

IPC: B32B1/08 ,  B01L3/00 ,  B29C65/46 ,  B29C65/48 ,  B32B17/06 ,  B32B27/28 ,  B32B27/34 ,  B32B27/36 ,  B32B7/12 ,  C09J5/06 ,  G01N21/05 ,  B29C65/00 ,  B29K71/00 ,  B29L23/00 ,  B29L31/00

Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.

公开(公告)号：US11499959B2

公开(公告)日：2022-11-15

申请号：US16463502

申请日：2016-12-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yoshimitsu Yanagawa ,  Kenichi Takeda ,  Itaru Yanagi ,  Yusuke Goto ,  Kazuma Matsui

IPC: G01N33/487 ,  B01J19/08 ,  C25F3/12 ,  B81C1/00 ,  G01N33/00 ,  B23H7/20

Abstract: A first modulation voltage is applied to a thin film. An amount of a change in the phase of a current carried through the thin film with respect to the phase of the first modulation voltage is compared with a threshold. Upon detecting that the amount of the change in the phase exceeds the threshold is detected, the application of the first modulation voltage is stopped. Thus, a nanopore is formed on the thin film at high speed.

公开(公告)号：US09975308B2

公开(公告)日：2018-05-22

申请号：US14646522

申请日：2013-11-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yusuke Goto ,  Masao Kamahori ,  Hiroshi Sasaki ,  Kiyotoshi Mori ,  Hideyuki Akiyama

IPC: B32B1/08 ,  B29C65/48 ,  B01L3/00 ,  B32B7/12 ,  B32B27/28 ,  B29C65/46 ,  B32B17/06 ,  C09J5/06 ,  G01N21/05 ,  B32B27/34 ,  B32B27/36 ,  B29K71/00 ,  B29L23/00 ,  B29L31/00

CPC classification number: B32B1/08 ,  B01L3/561 ,  B01L2300/12 ,  B29C65/46 ,  B29C65/4895 ,  B29C66/73117 ,  B29C66/7465 ,  B29K2071/00 ,  B29K2995/0026 ,  B29K2995/0058 ,  B29K2995/0077 ,  B29L2023/22 ,  B29L2031/752 ,  B32B7/12 ,  B32B17/064 ,  B32B27/281 ,  B32B27/285 ,  B32B27/286 ,  B32B27/288 ,  B32B27/34 ,  B32B27/365 ,  B32B2255/20 ,  B32B2597/00 ,  C09J5/06 ,  C09J2400/143 ,  C09J2400/226 ,  G01N21/05 ,  Y10T428/1321

Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.

公开(公告)号：US09658153B2

公开(公告)日：2017-05-23

申请号：US14363366

申请日：2012-10-30

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yusuke Goto ,  Masao Kamahori ,  Yu Ishige ,  Hiroshi Sasaki ,  Hideyuki Akiyama ,  Shintaro Kubo

IPC: G01N21/00 ,  G01N21/31 ,  G01N30/74 ,  G01N21/05 ,  G01N1/00 ,  G01N21/3577 ,  G01N21/03

CPC classification number: G01N21/31 ,  G01N1/00 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/3577 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2021/052

Abstract: To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.