公开(公告)号：US20070244527A1

公开(公告)日：2007-10-18

申请号：US11633639

申请日：2006-12-05

申请人： Hitoshi Hatayama ,  Akira Inoue ,  Hiroshi Suganuma ,  Junji Kato

发明人： Hitoshi Hatayama ,  Akira Inoue ,  Hiroshi Suganuma ,  Junji Kato

IPC分类号： A61N5/067

CPC分类号： A61B18/22 ,  A61B2017/00084 ,  A61B2018/00791 ,  A61B2018/20351 ,  A61B2018/207 ,  A61B2018/2211 ,  A61C1/0007 ,  A61C1/0046 ,  A61N2005/0606 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067

摘要： A dental treatment apparatus is provided with an irradiation unit, a temperature detection unit and a control unit. The irradiation unit is constituted by N number of first light emitting elements S1 to SN, N number of first focusing lenses L1 to LN, and N number of optic fibers F1 to FN, combined on a 1:1 basis, and optic fibers Fn are bundled on the output side of the irradiation unit. The first light emitting element Sn is an element which outputs laser light having a specific wavelength λ within a range of 400 nm to 420 nm. The temperature detection unit is constituted by a non-contact temperature sensor and a wire. The non-contact temperature sensor detects the temperature at a site irradiated with laser light output from an emergent end.

摘要翻译： 牙科治疗装置设置有照射单元，温度检测单元和控制单元。 照射单元由N个第一发光元件S 1〜S N N构成，N个第一聚焦透镜L 1〜L〜L N 1，N个光纤F 1到F N 1，以1：1为单位组合，并且光纤F < n 捆扎在照射单元的输出侧。 第一发光元件S N是将具有特定波长λ的激光输出在400nm至420nm的范围内的元件。 温度检测单元由非接触式温度传感器和电线构成。 非接触式温度传感器检测从紧急端射出的激光照射的部位的温度。

公开(公告)号：US20080057580A1

公开(公告)日：2008-03-06

申请号：US11892061

申请日：2007-08-20

申请人： Akira Inoue ,  Hitoshi Hatayama ,  Hiroshi Suganuma ,  Kunio Awazu ,  Toshihiro Kushibiki

发明人： Akira Inoue ,  Hitoshi Hatayama ,  Hiroshi Suganuma ,  Kunio Awazu ,  Toshihiro Kushibiki

IPC分类号： C12N5/02

CPC分类号： C12N5/0654 ,  C12N2506/1353 ,  C12N2529/10

摘要： The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive.

摘要翻译： 本发明提供了一种选择性分化诱导可以分化成构成各种组织和器官的细胞的成骨细胞的间充质干细胞的技术。 此外，本发明提供了一种技术，其通过简单的操作将间充质干细胞诱导成成骨细胞，其仅需要短时间并且是非侵入性的。 发明人已经发现通过将存在于间充质干细胞中的生物钟相关因子从细胞质细胞转移到细胞核来开启分化诱导成骨细胞的转换。 本发明人还发现，可以通过用具有特定波长的非侵入性的光波照射细胞短时间来开启开关。

公开(公告)号：US07829335B2

公开(公告)日：2010-11-09

申请号：US11892061

申请日：2007-08-20

申请人： Akira Inoue ,  Hitoshi Hatayama ,  Hiroshi Suganuma ,  Kunio Awazu ,  Toshihiro Kushibiki

发明人： Akira Inoue ,  Hitoshi Hatayama ,  Hiroshi Suganuma ,  Kunio Awazu ,  Toshihiro Kushibiki

IPC分类号： C12N5/00

CPC分类号： C12N5/0654 ,  C12N2506/1353 ,  C12N2529/10

摘要： The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive.

摘要翻译： 本发明提供了一种选择性分化诱导可以分化成构成各种组织和器官的细胞的成骨细胞的间充质干细胞的技术。 此外，本发明提供了一种技术，其通过简单的操作将间充质干细胞诱导成成骨细胞，其仅需要短时间并且是非侵入性的。 发明人已经发现通过将存在于间充质干细胞中的生物钟相关因子从细胞质细胞转移到细胞核来开启分化诱导成骨细胞的转换。 本发明人还发现，可以通过用具有特定波长的非侵入性的光波照射细胞短时间来开启开关。

公开(公告)号：US20110155709A1

公开(公告)日：2011-06-30

申请号：US13054459

申请日：2009-06-18

申请人： Eiichiro Yamada ,  Akira Inoue ,  Koji Nakazato ,  Hiroshi Kohda ,  Hitoshi Hatayama ,  Takemi Hasegawa

发明人： Eiichiro Yamada ,  Akira Inoue ,  Koji Nakazato ,  Hiroshi Kohda ,  Hitoshi Hatayama ,  Takemi Hasegawa

IPC分类号： B23K26/00

CPC分类号： G02B6/04 ,  B23K26/032 ,  B23K2101/40 ,  G01N21/95684

摘要： A laser processing apparatus 1 includes a processing light source 3 emitting processing light; an observation light emitting unit 4 emitting observation light; optical fibers 19 conducting light having a plurality of wavelengths generated at an electronic component 2; a detecting unit 5 detecting the light conducted by the optical fibers 19; and a control unit 31 controlling a light emitting state of the processing light emitting unit 3. The optical fibers 19 are categorized into four groups, and disposed so as to surround an optical fiber 18 conducting the processing light. The optical fibers 19 categorized into the four groups are capable of conducting the observation light to the electronic component 2 every group.

摘要翻译： 激光加工装置1包括发出处理光的处理光源3; 发射观察光的观察发光单元4; 在电子部件2处产生具有多个波长的光的光纤19; 检测由光纤19传导的光的检测单元5; 以及控制处理用发光单元3的发光状态的控制单元31.光纤19分为四组，并且设置成围绕进行处理光的光纤18。 分为四组的光纤19能够每组观察光到电子部件2。

公开(公告)号：US08546722B2

公开(公告)日：2013-10-01

申请号：US13054459

申请日：2009-06-18

申请人： Eiichiro Yamada ,  Akira Inoue ,  Koji Nakazato ,  Hiroshi Kohda ,  Hitoshi Hatayama ,  Takemi Hasegawa

发明人： Eiichiro Yamada ,  Akira Inoue ,  Koji Nakazato ,  Hiroshi Kohda ,  Hitoshi Hatayama ,  Takemi Hasegawa

IPC分类号： B23K26/03 ,  H01L21/02

CPC分类号： G02B6/04 ,  B23K26/032 ,  B23K2101/40 ,  G01N21/95684

摘要： A laser processing apparatus 1 includes a processing light source 3 emitting processing light; an observation light emitting unit 4 emitting observation light; optical fibers 19 conducting light having a plurality of wavelengths generated at an electronic component 2; a detecting unit 5 detecting the light conducted by the optical fibers 19; and a control unit 31 controlling a light emitting state of the processing light emitting unit 3. The optical fibers 19 are categorized into four groups, and disposed so as to surround an optical fiber 18 conducting the processing light. The optical fibers 19 categorized into the four groups are capable of conducting the observation light to the electronic component 2 every group.

摘要翻译： 激光加工装置1包括发出处理光的处理光源3; 发射观察光的观察发光单元4; 在电子部件2处产生具有多个波长的光的光纤19; 检测由光纤19传导的光的检测单元5; 以及控制处理用发光单元3的发光状态的控制单元31.光纤19分为四组，并且设置成围绕进行处理光的光纤18。 分为四组的光纤19能够每组观察光到电子部件2。

公开(公告)号：US20100068673A1

公开(公告)日：2010-03-18

申请号：US12523290

申请日：2008-01-16

申请人： Eiichiro Yamada ,  Akira Inoue ,  Hitoshi Hatayama

发明人： Eiichiro Yamada ,  Akira Inoue ,  Hitoshi Hatayama

IPC分类号： A61C3/00

CPC分类号： G01N21/474 ,  A61C1/0046 ,  A61C19/04 ,  B23K26/032 ,  B23K26/0608 ,  B23K26/0626 ,  B23K2101/36 ,  G01N21/314 ,  G01N2021/3137 ,  G01N2201/0618 ,  G01N2201/08

摘要： A laser processing apparatus 1 includes: a processing light source 2 for emitting a processing light for processing a tooth 13A or a gingiva 13B; a halogen lamp 3 for emitting an illumination light for illuminating the tooth 13A or the gingiva 13B; a detector 4 capable of detecting a multiple-wavelength light from the tooth 13A or the gingiva 13B; and a controller 5 for controlling the light-emitting state of the first light-emitting part 2. The detector 4 has a first detection element 6 and a second detection element 7 with light-receiving sensitivities that differ in accordance with wavelength, detects light intensities of different wavelengths, and outputs the detection result to the controller 5. The controller 5 controls the light-emitting state of the processing light source 2 on the basis of the ratio of the respective intensities of the different wavelength light detected by the detector 4.

摘要翻译： 激光加工设备1包括：处理光源2，用于发出用于处理牙齿13A或牙龈13B的处理光; 用于发射用于照明牙齿13A或牙龈13B的照明光的卤素灯3; 能够检测来自牙齿13A或牙龈13B的多波长光的检测器4; 以及用于控制第一发光部分2的发光状态的控制器5.检测器4具有第一检测元件6和具有根据波长不同的光接收灵敏度的第二检测元件7，检测光强度 并将检测结果输出到控制器5.控制器5基于由检测器4检测到的不同波长光的各自的强度的比率来控制处理光源2的发光状态。

公开(公告)号：US06782168B2

公开(公告)日：2004-08-24

申请号：US10175381

申请日：2002-06-20

申请人： Hitoshi Hatayama ,  Chisai Hirose ,  Masayuki Nishimura

发明人： Hitoshi Hatayama ,  Chisai Hirose ,  Masayuki Nishimura

IPC分类号： G02B626

CPC分类号： H04J14/02 ,  G02B6/12004 ,  G02B6/29352 ,  G02B6/29385 ,  G02B6/29395 ,  G02B6/29398 ,  G02B6/4215 ,  H04B10/077 ,  H04B10/07955

摘要： The invention provides an apparatus for and method of monitoring wavelength multiplexed signal light, which can obtain monitored data for multi-channel optical signals contained in the wavelength multiplexed signal light, which can avoid a large size and complicated structure and high cost of monitoring apparatus, and which can easily monitor the wavelength multiplexed signal light. The invention also provides an optical transmission system employing the monitoring apparatus and method. An optical filter being able to control a loss pattern is disposed on a monitoring waveguide for the wavelength multiplexed signal light, which is branched for monitoring from an input waveguide and an output waveguide constituting a main optical transmission path in a wavelength multiplexed signal light monitoring apparatus. While the optical filter sets a plurality of loss patterns in sequence, the wavelength multiplexed signal light having passed through the optical filter is detected by a photodiode for each of the loss patterns, and monitored data of the wavelength multiplexed signal light can be obtained from detected data.

摘要翻译： 本发明提供了一种监测波长多路复用信号光的装置和方法，可以获得波长复用信号光中包含的多通道光信号的监测数据，避免了尺寸大，结构复杂，成本高的监控装置， 并且可以容易地监视波长复用信号光。 本发明还提供一种采用监测装置和方法的光传输系统。 能够控制损耗图案的滤光器设置在用于波长多路复用信号光的监视波导上，该波长复用信号光在波长多路复用信号光监视装置中从构成主光传输路径的输入波导和输出波导进行监视分支 。 虽然光学滤波器依次设置多个损耗模式，但是通过光电二极管检测通过滤光器的波长多路复用信号光，并且可以通过检测到的波长复用信号光的监视数据 数据。

公开(公告)号：US06333807B1

公开(公告)日：2001-12-25

申请号：US09626450

申请日：2000-07-26

申请人： Hitoshi Hatayama ,  Eisuke Sasaoka

发明人： Hitoshi Hatayama ,  Eisuke Sasaoka

IPC分类号： G02F133

CPC分类号： H04B10/2941 ,  G02F1/0147 ,  G02F1/225 ,  G02F1/3136 ,  G02F2001/212 ,  G02F2001/311 ,  H01S3/06754 ,  H01S3/1301 ,  H01S2301/04 ,  H04B10/25073 ,  H04B10/296 ,  H04B2210/003 ,  H04J14/0221

摘要： The present invention relates to an optical filter comprising a simple structure which easily realizes slope control of loss spectrum in a signal wavelength band as a gain equalizer. The optical filter comprises a first Mach-Zehnder interferometer constituted by a first part of a main optical line, a first auxiliary optical line, and first and second optical couplers which optically couple the main optical line and first auxiliary optical line to each other. The optical filter further comprises a second Mach-Zehnder interferometer constituted by a second part of the main optical line, a second auxiliary optical line, and third and fourth optical couplers which optically couple the main optical line and second auxiliary optical line to each other. In particular, in order for the slope of loss spectrum in a signal wavelength band to be adjustable while being centered about the amount of loss of light at a reference wavelength propagating through the main optical line from its entrance end to exit end, at least one of the first part of main optical line and the first auxiliary optical line is provided with a first temperature regulating device, at least one of the second part of main optical line and the second auxiliary optical line is provided with a second temperature regulating device, and the first and second temperature regulating devices are controlled by a control system.

摘要翻译： 本发明涉及一种滤光器，其包括简单的结构，其容易地实现信号波长带中的损耗谱的斜率控制作为增益均衡器。 光学滤波器包括由主光线的第一部分，第一辅助光线以及将主光线和第一辅助光线相互光耦合的第一和第二光耦合器构成的第一马赫 - 曾德干涉仪。 滤光器还包括由主光线的第二部分，第二辅助光线构成的第二马赫 - 曾德干涉仪，以及将主光线和第二辅助光线相互光耦合的第三和第四光耦合器。 特别地，为了将信号波长带中的损耗谱的斜率调整为以从入射端到出射端传播通过主光线的参考波长的光损失量为中心，至少一个 主光路的第一部分和第一辅助光线设置有第一温度调节装置，主光线和第二辅助光线的第二部分中的至少一个设置有第二温度调节装置，并且 第一和第二温度调节装置由控制系统控制。

公开(公告)号：US06332055B1

公开(公告)日：2001-12-18

申请号：US09517521

申请日：2000-03-02

申请人： Hitoshi Hatayama ,  Eisuke Sasaoka

发明人： Hitoshi Hatayama ,  Eisuke Sasaoka

IPC分类号： G02B626

CPC分类号： G02B6/12019 ,  G02B6/12004 ,  G02B6/12026 ,  G02B6/122 ,  G02B2006/12147 ,  G02F1/0121 ,  G02F1/0147 ,  G02F1/225 ,  G02F2201/58 ,  G02F2203/48

摘要： The present invention relates to an optical attenuator or the like which is easy to manufacture and is able to be miniaturized. In an optical attenuator according to this invention, a plurality of Mach-Zehnder-type waveguide elements are arranged in parallel on the common substrate. Each Mach-Zehnder-type waveguide element is provided with an input optical waveguide, a first directional coupler, two optical waveguides, a second directional coupler, an output optical waveguide, a monitoring optical waveguide and a temperature regulator for regulating the temperature of one of the two optical waveguides. Particularly, between the Mach-Zehnder-type waveguide elements adjacent to each other, an monitoring optical waveguide of one thereof and an output optical waveguide of the other thereof are arranged to cross.

摘要翻译： 本发明涉及容易制造且能够小型化的光衰减器等。 在根据本发明的光衰减器中，多个马赫 - 曾德尔型波导元件平行布置在公共基板上。 每个马赫 - 策德尔型波导元件设置有输入光波导，第一定向耦合器，两个光波导，第二定向耦合器，输出光波导，监控光波导和用于调节温度的温度调节器 两个光波导。 特别地，在彼此相邻的马赫 - 策德尔型波导元件之间，其一个的监视光波导和另一个的监视光波导被布置成交叉。

公开(公告)号：US20060257085A1

公开(公告)日：2006-11-16

申请号：US10558630

申请日：2004-07-09

申请人： Hitoshi Hatayama ,  Eisuke Sasaoka

发明人： Hitoshi Hatayama ,  Eisuke Sasaoka

IPC分类号： G02B6/02

CPC分类号： H04B10/2563 ,  G02B6/02009 ,  G02B6/02223 ,  G02B6/02242 ,  G02B6/02257 ,  G02B6/02271 ,  G02B6/03644 ,  G02B6/29377

摘要： The present invention provides an optical transmission system and so on having a structure that enables to reduce variations between wavelengths in chromatic dispersion over a wide wavelength range and control non-linear optical effects. An optical fiber transmission line comprises a first optical fiber having a positive chromatic dispersion such that its wavelength dependence is reduced over a wide wavelength range, and a second optical fiber having a negative chromatic dispersion such that its wavelength dependence is reduced over the wavelength range. In this way, the first and second optical fibers each have a chromatic dispersion of a different polarity, thereby controlling accumulated chromatic dispersions at low level for a whole optical fiber transmission line, while the chromatic dispersion occurs to some extent in each of the first and second optical fibers, thereby controlling effectively non-linear optical effects such as four-wave mixing.

摘要翻译： 本发明提供了一种光传输系统等，其具有能够减小宽波长范围内的色散波长之间的变化并且控制非线性光学效果的结构。 光纤传输线包括具有正色散的第一光纤，使得其波长依赖性在宽波长范围内减小，并且具有负色散的第二光纤，使得其波长依赖性在波长范围内减小。 以这种方式，第一和第二光纤各自具有不同极性的色散，从而将整个光纤传输线的累积色散控制在低电平，同时在一定程度上在第一和第 第二光纤，从而有效地控制诸如四波混频的非线性光学效应。