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    SYSTEM FOR SIMULATING LUNG FUNCTION
    1.
    发明申请
    SYSTEM FOR SIMULATING LUNG FUNCTION 审中-公开
    模拟肺功能的系统

    公开(公告)号：US20140315175A1

    公开(公告)日：2014-10-23

    申请号：US13748346

    申请日：2013-01-23

    申请人： Hoang Nguyen ,  Ryan Olivera ,  Alex Yang ,  Sri Radhakrishnan ,  Steve Wallace ,  Surag Mantri ,  Greg Pulido ,  Ramon Estrada

    发明人： Hoang Nguyen ,  Ryan Olivera ,  Alex Yang ,  Sri Radhakrishnan ,  Steve Wallace ,  Surag Mantri ,  Greg Pulido ,  Ramon Estrada

    IPC分类号： G09B23/32

    CPC分类号： G09B23/32 ,  G09B23/30

    摘要： A system for simulating a breathing lung is disclosed. The system comprises a lung model contained within an enclosure, wherein a main bronchus of the lung model is open to ambient air. In one embodiment, the system also comprises a vacuum pump connected to the enclosure, a first normally closed 2-way valve connected to the enclosure, a flow controller connected to both the vacuum pump and the enclosure, and a timer connected to the first normally closed 2-way valve. In alternative embodiments, the system comprises a first pump connected to the enclosure and a second pump connected to the enclosure, wherein the first and second pumps work independently of each other, and wherein the first pump is a vacuum pump, and the second pump is either a peristaltic pump or a piston pump.

    摘要翻译： 公开了一种用于模拟呼吸肺的系统。 该系统包括包含在外壳内的肺模型，其中肺模型的主支气管对环境空气开放。 在一个实施例中，系统还包括连接到外壳的真空泵，连接到外壳的第一常闭二通阀，连接到真空泵和外壳的流量控制器以及连接到第一正常的定时器 关闭二通阀。 在替代实施例中，系统包括连接到外壳的第一泵和连接到外壳的第二泵，其中第一和第二泵彼此独立地工作，并且其中第一泵是真空泵，第二泵是 蠕动泵或活塞泵。

    GASTRO-INTESTINLAL COMPRESSION DEVICE
    2.
    发明申请
    GASTRO-INTESTINLAL COMPRESSION DEVICE 有权
    GASTRO-INTESTINLAL压缩装置

    公开(公告)号：US20120065651A1

    公开(公告)日：2012-03-15

    申请号：US13186429

    申请日：2011-07-19

    申请人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    发明人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    IPC分类号： A61B17/11

    CPC分类号： A61B17/1114 ,  A61B2017/00818 ,  A61B2017/1132 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045

    摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.

    摘要翻译： 公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。 在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件， 其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。 通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS
    3.
    发明申请
    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 审中-公开
    内分泌诊断的方法与系统

    公开(公告)号：US20110295141A1

    公开(公告)日：2011-12-01

    申请号：US12954499

    申请日：2010-11-24

    申请人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    发明人： Srikanth Radhakrishnan ,  Ryan Olivera ,  Niyazi Beyhan ,  Surag Mantri ,  Lutz Freitag

    IPC分类号： A61B5/08

    CPC分类号： A61B5/082

    摘要： A method for assessing lung function in a patient is disclosed. The method comprises isolating a lung compartment. Thereafter, in one embodiment, an inhaled gas of known composition is introduced into the lung and compared to the composition of the exhaled gas. Alternatively, accumulated CO2 content is measured within the isolated lung compartment over time, and compared to a baseline CO2 content. Alternatively, a change in pressure of an isolated lung compartment may be monitored. Alternatively, the magnitude of the range of CO2 values in an isolated lung compartment can be compared to a predetermined threshold. Any of the results obtained via these alternative embodiments may be used to determine lung function.

    摘要翻译： 公开了一种用于评估患者的肺功能的方法。 该方法包括分离肺隔室。 此后，在一个实施方案中，将已知组合物的吸入气体引入肺中并与呼出气体的组成进行比较。 或者，随着时间的推移在隔离的肺隔室内测量累积的CO 2含量，并与基线CO 2含量进行比较。 或者，可以监测隔离的肺隔室的压力变化。 或者，可以将隔离的肺隔室中的CO 2值的范围的大小与预定阈值进行比较。 通过这些替代实施方案获得的任何结果可用于确定肺功能。

    MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL
    5.
    发明申请
    MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL 有权
    测量肺功能和肺功能障碍进展

    公开(公告)号：US20110313307A1

    公开(公告)日：2011-12-22

    申请号：US12964515

    申请日：2010-12-09

    申请人： Srikanth Radhakrishnan ,  Surag Mantri ,  Ryan Olivera

    发明人： Srikanth Radhakrishnan ,  Surag Mantri ,  Ryan Olivera

    IPC分类号： A61B5/085

    CPC分类号： A61B5/085 ,  A61B5/087 ,  A61B5/097 ,  A61B5/6853 ,  A61B5/7278 ,  A61B2562/0247

    摘要： A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.

    摘要翻译： 公开了一种用于确定患者的肺功能的方法，其中使用其末端具有可扩张闭塞元件的多腔导管来分离靶向的肺隔室，并且在多个呼吸循环中测量目标肺隔室处的呼吸特征 。 呼吸周期的各种特征之间的关系用于确定目标肺隔室内肺组织的依从性。

    DEVICES AND METHODS FOR SAFELY ACCESSING BONE MARROW AND OTHER TISSUES
    6.
    发明申请
    DEVICES AND METHODS FOR SAFELY ACCESSING BONE MARROW AND OTHER TISSUES 审中-公开
    用于安全地接受骨髓和其他组织的装置和方法

    公开(公告)号：US20100152616A1

    公开(公告)日：2010-06-17

    申请号：US12699847

    申请日：2010-02-03

    申请人： Niyazi Beyhan ,  Surag Mantri ,  Hoang Nguyen

    发明人： Niyazi Beyhan ,  Surag Mantri ,  Hoang Nguyen

    IPC分类号： A61B10/00

    CPC分类号： A61B10/025

    摘要： A device for safely accessing bone marrow and other tissues is disclosed. Such device comprises a needle assembly, a sensor mechanism, and an actuator configured to engage with the needle assembly via the sensor mechanism to advance a tissue penetrable needle through a first tissue region and into a second tissue region. In one aspect, the first tissue region is a bone cortex and the second tissue region is a bone marrow cavity. The sensor mechanism is configured to disengage the actuator from the needle once the needle has crossed the first tissue region (e.g., bone cortex) into the second tissue region (e.g., bone marrow cavity), thereby preventing the needle from advancing further into the second tissue region. In one aspect, the sensor mechanism is mechanical and comprises a pin assembly comprising a spring-loaded pin that extends through the needle. The pin assembly is configured such that advancement of the distal tip of the spring-loaded pin past the distal tip of the needle causes the actuator to disengage from the needle. The actuator is a rotatable actuator. A catheter-based embodiment of the device can be inserted in body passageways to access tissue internally within the body.

    摘要翻译： 公开了一种用于安全进入骨髓和其他组织的装置。 这种装置包括针组件，传感器机构和致动器，其构造成经由传感器机构与针组件接合，以将组织穿透针推进穿过第一组织区域并进入第二组织区域。 在一个方面，第一组织区域是骨皮质，第二组织区域是骨髓腔。 一旦针已经穿过第一组织区域（例如，骨皮质）进入第二组织区域（例如，骨髓腔），传感器机构构造成使致动器与针脱离，从而防止针进一步进入第二组织区域 组织区域。 在一个方面，传感器机构是机械的并且包括销组件，其包括延伸穿过针的弹簧加载销。 销组件被构造成使得弹簧加载的销的远端顶端超过针的远端使得致动器与针脱离。 致动器是可旋转的致动器。 该装置的基于导管的实施例可以插入身体通道中以在体内内部进入组织。

    Gastro-intestinal compression device
    7.
    发明授权
    Gastro-intestinal compression device 有权
    胃肠压缩装置

    公开(公告)号：US08870807B2

    公开(公告)日：2014-10-28

    申请号：US13186429

    申请日：2011-07-19

    申请人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    发明人： Surag Mantri ,  Hoang Nguyen ,  Niyazi Beyhan

    IPC分类号： A61F2/04 ,  A61M5/00 ,  A61B17/11 ,  A61F5/00 ,  A61B17/00

    CPC分类号： A61B17/1114 ,  A61B2017/00818 ,  A61B2017/1132 ,  A61F5/0076 ,  A61F2002/044 ,  A61F2002/045

    摘要： Devices, methods, and systems for treating Type-2 Diabetes and/or obesity by facilitating the delivery of under-digested nutrients within the gastro-intestinal tract without substantial tissue removal are disclosed. In one aspect, the gastro-intestinal tract of a patient is modified by a gastro-intestinal treatment device comprising an elongate element configured to extend within the gastro-intestinal tract, a first attachment element and a second attachment element disposed on the elongate element, wherein the first attachment element and the second attachment element are configured to attach to the gastro-intestinal tract such that a portion of the gastro-intestinal tract is compressed between the first and the second attachment elements. The length of the gastro-intestinal tract modified by the device is effectively shortened, and its surface area is reduced.

    摘要翻译： 公开了通过促进胃肠道内消化不良的营养物质的递送而不需要大量去除组织来治疗2型糖尿病和/或肥胖症的装置，方法和系统。 在一个方面，患者的胃肠道由胃肠治疗装置改变，所述胃肠治疗装置包括构造成在胃肠道内延伸的细长元件，设置在细长元件上的第一附接元件和第二附接元件， 其中所述第一附接元件和所述第二附接元件构造成附接到胃肠道，使得胃肠道的一部分在第一和第二附接元件之间被压缩。 通过该装置修改的胃肠道的长度被有效地缩短，并且其表面积减小。

    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS
    9.
    发明申请
    METHODS AND SYSTEMS FOR ENDOBRONCHIAL DIAGNOSTICS 有权
    内分泌诊断的方法与系统

    公开(公告)号：US20120149995A1

    公开(公告)日：2012-06-14

    申请号：US13174633

    申请日：2011-06-30

    申请人： Surag Mantri ,  Srikanth Radhakrishnan

    发明人： Surag Mantri ,  Srikanth Radhakrishnan

    IPC分类号： A61B5/08 ,  A61B5/145 ,  A61B5/091 ,  A61M16/06 ,  A61B5/087 ,  A61B5/085

    CPC分类号： A61B5/14552 ,  A61B1/00082 ,  A61B1/2676 ,  A61B5/08 ,  A61B5/085 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/6853 ,  A61M16/0003 ,  A61M16/0404 ,  A61M2016/0036 ,  A61M2016/102 ,  A61M2230/205 ,  A61M2230/43

    摘要： Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.

    摘要翻译： 公开了用于靶向，访问和诊断患病肺隔室的方法和系统。 该方法包括通过辅助通气装置将具有阻塞构件的诊断导管在其远端引入肺段; 使闭塞部件膨胀以分离肺段; 并且在患者通气时用导管执行诊断程序。 诊断导管的近端被配置为附接到控制台。 该方法还可以包括将诊断导管引入肺段中; 使闭塞部件膨胀以分离肺段; 并监测血氧饱和度。 该方法还可以包括将诊断导管引入肺部段中; 确定肺段的潮汐流量; 确定患者的总肺容量; 并且基于肺段的潮汐流量和总肺容量来确定流量值。