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    Method and apparatus for ultrafiltration utilizing a long peripheral access venous cannula for blood withdrawal
    1.
    发明授权
    Method and apparatus for ultrafiltration utilizing a long peripheral access venous cannula for blood withdrawal 有权
    用于超滤的方法和装置，其利用长周边通路静脉插管进行抽血

    公开(公告)号：US06685664B2

    公开(公告)日：2004-02-03

    申请号：US09876185

    申请日：2001-06-08

    申请人： Howard R. Levin ,  Mark Gelfand ,  Steve Bernard

    发明人： Howard R. Levin ,  Mark Gelfand ,  Steve Bernard

    IPC分类号： A61M3700

    CPC分类号： A61M1/34 ,  A61M1/36 ,  A61M25/0014 ,  A61M2205/15 ,  A61M2205/502

    摘要： Method and apparatus for the extracorporeal treatment of blood by utilizing a peripherally inserted catheter assembly for the continuous removal of blood for renal replacement treatment, in particularly, treatment of congestive heart failure and fluid overload by ultrafiltration. A catheter is inserted in a peripheral vein and maneuvered upward through the vascular system to access the reservoir of blood in the large or great veins for continuous blood withdrawal and treatment. Air-tight connectors are incorporated in the catheter assembly to overcome the untoward effects of negative pressure in blood withdrawal.

    摘要翻译： 通过利用外周插入的导管组件连续去除血液进行肾脏替代治疗，特别是通过超滤治疗充血性心力衰竭和流体过载来体外治疗血液的方法和装置。 将导管插入外周静脉，并通过血管系统向上操作，以进入大静脉中的血液储存器，用于持续取血和治疗。 气密连接器被结合在导管组件中以克服抽血中负压的不利影响。

    Kidney perfusion catheter
    2.
    发明授权
    Kidney perfusion catheter 有权
    肾灌注导管

    公开(公告)号：US06592567B1

    公开(公告)日：2003-07-15

    申请号：US09454605

    申请日：1999-12-07

    申请人： Howard R. Levin ,  Mark Gelfand ,  Steve Bernard

    发明人： Howard R. Levin ,  Mark Gelfand ,  Steve Bernard

    IPC分类号： A61M3100

    CPC分类号： A61M25/0069 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1095

    摘要： A kidney perfusion catheter assembly is disclosed having an introducer catheter, a renal artery seal, a perfusion tip, and a guide wire. The perfusion catheter provides a flow of supplemental blood to increase the local blood pressure in the renal artery and to perfuse the kidney. The introducer catheter is maneuvered through the femoral artery to the aorta and positioned at the branch of a renal artery. The perfusion catheter tip is telescoped from the distal end of the introducer catheter into the renal artery. A blood pump attached to the proximal end of the perfusion catheter assembly provides a flow of blood that streams from the perfusion catheter tip into the renal artery. This stream of blood increases the pressure and volume of the blood flowing through the renal artery. The catheter includes a seal to block the opening of the renal artery to prevent the runoff of the blood from the renal artery into the aorta. The catheter also includes a brace to secure the perfusion catheter tip in the aorta without distending the renal artery.

    摘要翻译： 公开了一种具有导引导管，肾动脉密封，灌注尖和导丝的肾灌注导管组件。 灌注导管提供补充血液的流动，以增加肾动脉中的局部血压并灌注肾脏。 引导导管通过股动脉操纵到主动脉并且位于肾动脉的分支处。 灌注导管尖端从导引导管的远端伸入肾动脉。 附接到灌注导管组件的近端的血泵提供从灌注导管尖端流入肾动脉的血液流。 血流增加了流经肾动脉的血液的压力和体积。 该导管包括封闭肾动脉开口以防止血液从肾动脉径流进入主动脉的密封。 导管还包括支架，用于将灌注导管尖端固定在主动脉中，而不会使肾动脉膨胀。

    Method and apparatus for ultrafiltration of blood
    8.
    发明授权
    Method and apparatus for ultrafiltration of blood 有权
    超滤血液的方法和装置

    公开(公告)号：US08603021B2

    公开(公告)日：2013-12-10

    申请号：US13098853

    申请日：2011-05-02

    申请人： Howard R. Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

    发明人： Howard R. Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

    IPC分类号： A61M37/00 ,  C02F1/44

    CPC分类号： A61M1/341 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/361 ,  A61M1/3612 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/7563

    摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.

    摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。