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公开(公告)号：US11333604B2
公开(公告)日：2022-05-17
申请号：US16948524
申请日：2020-09-22
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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公开(公告)号：US20250052565A1
公开(公告)日：2025-02-13
申请号：US18799507
申请日：2024-08-09
Applicant: ILLUMINA, INC.
Inventor： Shamsul Abedin , John Earney , Charles Hubert , Joseph Pinto , Arthur Pitera , Spencer Williams , Brandon Wenning , Clayton Braga
IPC: G01B11/27
Abstract: An example optical alignment target includes a translucent or transparent substrate having a bottom surface; an opaque material formed over the bottom surface in a pattern; an enclosed channel disposed below the bottom surface; and a fluid suspension contained in the enclosed channel. The pattern has an opaque portion of an opaque material and has a gap portion devoid of the opaque material. The fluid suspension includes a carrier liquid and a light emitting material suspended in the carrier liquid. The light emitting material is selected from the group consisting of quantum dots and cerium powder.
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公开(公告)号：US20230393379A1
公开(公告)日：2023-12-07
申请号：US18236088
申请日：2023-08-21
Applicant: ILLUMINA, INC.
Inventor： Robert Langlois , Bo Lu , Hongji Ren , Joseph Pinto , Simon Prince , Austin Corbett
CPC classification number: G02B21/367 , G02B21/14 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
Abstract: A method is used to generate a distortion model for a structured illumination microscopy (SIM) optical system. A sliding window is moved in relation to a plurality of images to define a plurality of sub-tiles. Each sub-tile represents a portion of the corresponding image. Parameters are estimated for each sub-tiles. The parameters include two or more parameters selected from the group consisting of modulation, angle, spacing, phase offset, and phase deviation. A full width at half maximum (FWHM) value associated with each sub-tile is estimated. A distortion model is estimated, based at least in part on a combination of the estimated parameters and FWHM values stored in the predetermined format and an estimated center window parameter. A two-dimensional image may be generated, based at least in part on the estimated distortion model. The two-dimensional image may include representations indicating where distortions occur in the optical system.
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公开(公告)号：US11243390B2
公开(公告)日：2022-02-08
申请号：US17110406
申请日：2020-12-03
Applicant: ILLUMINA, INC.
Inventor： Austin Corbett , Bo Lu , Robert Langlois , Joseph Pinto , Yu Chen , Peter Newman , Hongji Ren
Abstract: A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.
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公开(公告)号：US10005083B2
公开(公告)日：2018-06-26
申请号：US15382684
申请日：2016-12-18
Applicant: Illumina, Inc.
Inventor： John Earney , Dakota Watson , Joseph Pinto
CPC classification number: B01L3/502715 , B01L3/502723 , B01L2300/0816 , B01L2300/0819 , B01L2300/0883 , B01L2300/14 , C12Q1/6874 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/058 , G01N2021/6439 , G01N2021/6482 , H04N17/002
Abstract: Provided is an inspection apparatus including: (a) a translucent or transparent plate having a bottom surface, at least a portion of the bottom surface having an opaque material printed thereon in a pattern having at least one transparent or translucent portion; and (b) a chamber disposed below the bottom surface, whereby light emitted from the chamber or through the chamber can pass through the at least one transparent or translucent portion.
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Patent Agency Ranking
公开(公告)号：US20170151565A1
公开(公告)日：2017-06-01
申请号：US15382684
申请日：2016-12-18
Applicant: Illumina, Inc.
Inventor： John Earney , Dakota Watson , Joseph Pinto
CPC classification number: B01L3/502715 , B01L3/502723 , B01L2300/0816 , B01L2300/0819 , B01L2300/0883 , B01L2300/14 , C12Q1/6874 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/058 , G01N2021/6439 , G01N2021/6482 , H04N17/002
Abstract: Provided is an inspection apparatus including: (a) a translucent or transparent plate having a bottom surface, at least a portion of the bottom surface having an opaque material printed thereon in a pattern having at least one transparent or translucent portion; and (h) a chamber disposed below the bottom surface, whereby light emitted from the chamber or through the chamber can pass through the at least one transparent or translucent portion.
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公开(公告)号：US12204086B2
公开(公告)日：2025-01-21
申请号：US18236088
申请日：2023-08-21
Applicant: ILLUMINA, INC.
Inventor： Robert Langlois , Bo Lu , Hongji Ren , Joseph Pinto , Simon Prince , Austin Corbett
Abstract: A method is used to generate a distortion model for a structured illumination microscopy (SIM) optical system. A sliding window is moved in relation to a plurality of images to define a plurality of sub-tiles. Each sub-tile represents a portion of the corresponding image. Parameters are estimated for each sub-tiles. The parameters include two or more parameters selected from the group consisting of modulation, angle, spacing, phase offset, and phase deviation. A full width at half maximum (FWHM) value associated with each sub-tile is estimated. A distortion model is estimated, based at least in part on a combination of the estimated parameters and FWHM values stored in the predetermined format and an estimated center window parameter. A two-dimensional image may be generated, based at least in part on the estimated distortion model. The two-dimensional image may include representations indicating where distortions occur in the optical system.
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公开(公告)号：US12123833B2
公开(公告)日：2024-10-22
申请号：US18512284
申请日：2023-11-17
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
CPC classification number: G01N21/6428 , G01N21/6454 , G01N33/53 , G01N2021/6471 , G01N2201/08
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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公开(公告)号：US10883937B2
公开(公告)日：2021-01-05
申请号：US16778935
申请日：2020-01-31
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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公开(公告)号：US10551317B2
公开(公告)日：2020-02-04
申请号：US16206564
申请日：2018-11-30
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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