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    PARALLEL SAMPLE AND INDEX SEQUENCING
    1.
    发明公开
    PARALLEL SAMPLE AND INDEX SEQUENCING 审中-公开

    公开(公告)号：US20230183799A1

    公开(公告)日：2023-06-15

    申请号：US18063581

    申请日：2022-12-08

    申请人： Illumina, Inc.

    发明人： Shaun E. Hunter ,  Paul Sangiorgio ,  Aathavan Karunakaran ,  David Bracher

    IPC分类号： C12Q1/6874

    CPC分类号： C12Q1/6874 ,  C12Q1/6806

    摘要： Systems and methods of identifying nucleobases in a template polynucleotide are disclosed. In one embodiment, such a method may include providing a substrate comprising a plurality of the template polynucleotides in a cluster. The method may further include generating light to stimulate fluorescent emissions from the cluster. The method may further include receiving a first signal emitted at a first intensity from a first plurality of nucleotide analogs hybridized to the plurality of template polynucleotides at a first site. The method may further include receiving a second signal emitted at a second intensity from a second plurality of nucleotide analogs hybridized to the plurality of template polynucleotides at a second site. The method may further include identifying the nucleobases hybridized at the first and second sites of the template polynucleotide based on a combination of the first and second signals.

    DYNAMIC DETILT FOCUS TRACKING
    4.
    发明公开
    DYNAMIC DETILT FOCUS TRACKING 审中-公开

    公开(公告)号：US20230228984A1

    公开(公告)日：2023-07-20

    申请号：US18097947

    申请日：2023-01-17

    申请人： ILLUMINA, INC.

    发明人： Dakota Watson ,  Merek Siu ,  Dustin Blair ,  Danilo Condello ,  John Earney ,  Paul Sangiorgio

    IPC分类号： G02B21/24 ,  G02B21/26 ,  G02B21/00 ,  H04N23/56

    CPC分类号： G02B21/245 ,  G02B21/26 ,  G02B21/0036 ,  G02B21/0032 ,  H04N23/56 ,  G02B21/0076 ,  G02B21/362

    摘要： Some implementations of the disclosure relate to an imaging system, including: a sample holder to support a sample container having multiple sample locations; an optical stage having; an assembly comprising one or more actuators physically coupled to the sample holder to tilt the sample holder relative to the optical stage during imaging of the multiple sample locations to focus the optical stage onto a current sample location; a first light source to project a first pair of spots on the sample container; and a controller to control, based on a sample tilt determined from a first separation measurement of the first pair of spots from one or more images taken by an image sensor at one or more of the sample locations, the one or more actuators to tilt the sample holder along a first direction of the imaging or a second direction substantially perpendicular to the first direction.

    System and method for sequestered wash buffered reuse
    5.
    发明授权
    System and method for sequestered wash buffered reuse 有权

    公开(公告)号：US11426723B2

    公开(公告)日：2022-08-30

    申请号：US16584353

    申请日：2019-09-26

    申请人： Illumina, Inc.

    发明人： Wesley A. Cox-Muranami ,  Kay Klausing ,  Bradley Kent Drews ,  Nicholas Watson ,  Jennifer Olivia Foley ,  Murphy Hitchcock ,  Paul Sangiorgio ,  Sz-Chin Steven Lin

    IPC分类号： B01L3/00

    摘要： A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

    JITTER CORRECTION IMAGE ANALYSIS
    6.
    发明公开
    JITTER CORRECTION IMAGE ANALYSIS 审中-公开

    公开(公告)号：US20240257320A1

    公开(公告)日：2024-08-01

    申请号：US18405320

    申请日：2024-01-05

    申请人： Illumina, Inc.

    发明人： Robert Ezra Langlois ,  Hongji Ren ,  Mohamed Khaled Mohamed Geunady ,  John S. Vieceli ,  Gregory Holst ,  Paul Sangiorgio

    IPC分类号： G06T5/80 ,  G06T3/02 ,  G06T7/73

    CPC分类号： G06T5/80 ,  G06T3/02 ,  G06T7/74 ,  G06T2207/30072

    摘要： Systems, methods, and apparatuses are described herein. For instance, a detection apparatus may comprise memory and at least one processor. The detection apparatus may be configured to obtain an image comprising at least one feature and a plurality of fiducials. The plurality of fiducials may be arranged in a pattern. The detection apparatus may be configured to determine a plurality of sub-regions of the image. Each sub-region comprises a subset of the fiducials comprised in the image. The detection apparatus may be configured to perform a geometric transform on each sub-region to generate a respective local transform associated with each sub-region. The detection apparatus may be configured to register respective locations of the fiducials comprised in the image based on the respective local transform associated with each sub-region. A size of each sub-region may be selected such that each sub-region is substantially invariant to stage jitter.