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公开(公告)号：US20220315809A1
公开(公告)日：2022-10-06
申请号：US17433734
申请日：2020-02-27
申请人： IMMUNOLIGHT, LLC
发明人： Frederic A. BOURKE, JR. , Harold WALDER , Zakaryae FATHI , Wayne F. BEYER , Ronald A. RUDDER , Joseph H. SIMMONS
IPC分类号： C09J133/08
摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.
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公开(公告)号：US20220181292A1
公开(公告)日：2022-06-09
申请号：US17647275
申请日：2022-01-06
申请人： IMMUNOLIGHT, LLC
IPC分类号： H01L23/00 , C08K3/00 , B41J2/175 , C09J4/00 , A61B17/00 , A61L24/06 , B32B37/12 , B32B37/18 , B32B38/00 , C09J133/08 , C09K11/02 , C09K11/77 , H01L25/065 , H01L25/00 , B32B3/26 , B32B7/14 , B32B9/04 , C09J9/02 , C09J11/04 , C09J11/06 , H01L23/522
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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公开(公告)号：US20200215611A1
公开(公告)日：2020-07-09
申请号：US16819806
申请日：2020-03-16
申请人： IMMUNOLIGHT, LLC.
IPC分类号： B22F3/105 , B33Y30/00 , B23K26/354 , B33Y10/00 , B22F7/06 , B23K26/34 , B33Y80/00 , B33Y50/02 , B22F5/04
摘要： A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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4.发明申请公开(公告)号：US20160362534A1
公开(公告)日：2016-12-15
申请号：US15183110
申请日：2016-06-15
申请人： Immunolight, LLC.
CPC分类号： C08J11/10 , B32B7/04 , B32B38/10 , B32B43/006 , C08J2321/00 , Y02W30/702 , Y10T156/1153 , Y10T156/1917
摘要： A method is provided for de-bonding objects contained in an article at an interface between the objects, wherein the objects are joined at the interface through an intermediate layer, which involves applying energy from a radiation source, wherein the energy is sufficient to cause destruction of bonds within the intermediate layer; and separating the two objects from one another.
摘要翻译： 提供了一种用于将包含在物品中的物体去粘合在物体之间的界面处的物体的方法，其中物体在界面处通过中间层连接，该中间层涉及从辐射源施加能量，其中能量足以引起破坏 的中间层内的键; 并将两个物体彼此分开。
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公开(公告)号：US20160325111A1
公开(公告)日：2016-11-10
申请号：US15151642
申请日：2016-05-11
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
CPC分类号： A61N5/062 , A61K41/0057 , A61K41/0061 , A61K47/6923 , A61N5/022 , A61N5/0618 , A61N5/0622 , A61N5/10 , A61N2005/0642 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在存在一种或多种等离子体激元活性剂的情况下进行，从而产生效果或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。
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公开(公告)号：US20210353954A1
公开(公告)日：2021-11-18
申请号：US17443981
申请日：2021-07-29
申请人： IMMUNOLIGHT, LLC
IPC分类号： A61N5/06 , A61K31/015 , A61K31/37 , A61K31/519 , A61K41/00 , A61M31/00 , A61N1/40
摘要： A system and method for emitting a wavelength of energy internal to a medium or internal to a human or animal subject, and methods for using the system in the treatment of a condition, disorder, or disease. The system includes 1) a source configured to produce an initiation signal penetrating at least a part of the medium or the human or animal subject and 2) an insertion device having an electronics assembly unit. The assembly unit includes 1) an emitter configured to emit the wavelength of energy of a predetermined type to treat a disease or disorder in the human or animal subject or to produce a change in the medium and 2) a receiver that receives the signal.
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公开(公告)号：US20200323711A1
公开(公告)日：2020-10-15
申请号：US16915058
申请日：2020-06-29
申请人： Immunolight, LLC
IPC分类号： A61F13/551 , A61F13/20 , A61F13/26
摘要： A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.
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公开(公告)号：US20200078600A1
公开(公告)日：2020-03-12
申请号：US16516463
申请日：2019-07-19
申请人： Immunolight, LLC. , Duke University
发明人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian Nicholas STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
IPC分类号： A61N5/06 , A61K49/00 , A61N1/40 , A61N5/02 , A61B5/00 , A61B5/055 , A61B6/00 , A61K41/00 , A61M5/00 , A61L2/00
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号：US20190336786A1
公开(公告)日：2019-11-07
申请号：US16511605
申请日：2019-07-15
申请人： Immunolight, LLC. , Duke University
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
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公开(公告)号：US20190336605A1
公开(公告)日：2019-11-07
申请号：US16514066
申请日：2019-07-17
申请人： Immunolight, LLC.
IPC分类号： A61K41/00 , A61K31/37 , A61F7/00 , A61K45/06 , A61K31/35 , A61K31/714 , A61N5/06 , A61H23/00 , A61K31/366 , A61N2/02 , A61K47/02 , A61N5/10
摘要： Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.
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