公开(公告)号：US20220062419A1

公开(公告)日：2022-03-03

申请号：US17227753

申请日：2021-04-12

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Mark OLDHAM ,  Justus ADAMSON ,  Mark W. DEWHIRST ,  Paul YOON ,  Harold WALDER ,  Frederic A. Bourke, JR. ,  Zakaryae FATHI ,  Wayne F. BEYER, JR.

IPC: A61K41/00 ,  A61N5/06 ,  A61K31/655 ,  A61K33/02 ,  A61K31/409 ,  A61K31/525 ,  A61K31/352 ,  A61K31/403 ,  A61K33/242 ,  A61K33/244 ,  A61K33/24 ,  A61N5/10

Abstract: A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

公开(公告)号：US20240216713A1

公开(公告)日：2024-07-04

申请号：US18435235

申请日：2024-02-07

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER, JR. ,  Ronald A. RUDDER ,  Joseph H. SIMMONS

IPC: A61N5/06 ,  A61K35/12 ,  A61K41/00 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/06 ,  H01L31/055

CPC classification number: A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

Abstract: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, such as color enhancement, and color enhancement structures containing the same.

公开(公告)号：US20210353954A1

公开(公告)日：2021-11-18

申请号：US17443981

申请日：2021-07-29

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER, JR.

IPC: A61N5/06 ,  A61K31/015 ,  A61K31/37 ,  A61K31/519 ,  A61K41/00 ,  A61M31/00 ,  A61N1/40

Abstract: A system and method for emitting a wavelength of energy internal to a medium or internal to a human or animal subject, and methods for using the system in the treatment of a condition, disorder, or disease. The system includes 1) a source configured to produce an initiation signal penetrating at least a part of the medium or the human or animal subject and 2) an insertion device having an electronics assembly unit. The assembly unit includes 1) an emitter configured to emit the wavelength of energy of a predetermined type to treat a disease or disorder in the human or animal subject or to produce a change in the medium and 2) a receiver that receives the signal.

公开(公告)号：US20150202294A1

公开(公告)日：2015-07-23

申请号：US14603539

申请日：2015-01-23

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Wenle XIA ,  David GOODEN ,  Erik J. SODERBLOM ,  Eric J. TOONE ,  Neil L. SPECTOR ,  Wayne F. BEYER, JR. ,  Harold WALDER

IPC: A61K41/00 ,  A61K51/12 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/436 ,  A61K31/517

CPC classification number: A61K31/436 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/517 ,  A61K41/0066 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

Abstract translation: 用于治疗受试者细胞增殖疾病或病症的方法，包括将缺乏DNA交联基序的补骨脂素衍生物施用于癌细胞，施用补骨脂素或其衍生物和拉帕替尼，或施用补骨脂素或其衍生物和神经胶质细胞 ，并且进一步施加起始辐射能量形成能量源。

公开(公告)号：US20240115878A1

公开(公告)日：2024-04-11

申请号：US18541531

申请日：2023-12-15

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. BOURKE, JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER, JR. ,  Ronald A. RUDDER ,  Daniel I. BECKER ,  Joseph H. SIMMONS

IPC: A61N5/06 ,  A61K35/12 ,  A61K41/00 ,  A61N5/067 ,  C09J133/08 ,  C09K11/02 ,  C09K11/59 ,  C09K11/76 ,  C09K11/77 ,  C12N15/01 ,  F21K2/00 ,  F21S11/00 ,  F21V9/40 ,  H01J45/00 ,  H01L23/00 ,  H01L31/0352 ,  H01L31/054 ,  H01L31/06

CPC classification number: A61N5/0625 ,  A61K35/12 ,  A61K41/00 ,  A61K41/0057 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/067 ,  C09J133/08 ,  C09K11/025 ,  C09K11/595 ,  C09K11/76 ,  C09K11/7701 ,  C09K11/7792 ,  C12N15/01 ,  F21K2/00 ,  F21S11/007 ,  F21V9/40 ,  H01J45/00 ,  H01L24/29 ,  H01L24/83 ,  H01L31/035281 ,  H01L31/054 ,  H01L31/06 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/0663 ,  H01L31/055 ,  H01L2224/2919 ,  H01L2224/29393 ,  H01L2224/8322 ,  H01L2224/83855

Abstract: An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, especially in the field of solar cells and other energy conversion devices.

公开(公告)号：US20190134419A1

公开(公告)日：2019-05-09

申请号：US16096174

申请日：2017-04-25

Applicant: Immunolight, LLC

Inventor： Frederic A. BOURKE JR. ,  Harold WALDER ,  Zakaryae FATHI ,  Wayne F. BEYER, JR.

IPC: A61N5/06 ,  A61N1/40 ,  A61N5/04 ,  A61M31/00 ,  A61K41/00

Abstract: A system and method for emitting a wavelength of energy internal to a medium or internal to a human or animal subject, and methods for using the system in the treatment of a condition, disorder, or disease. The system includes 1) a source configured to produce an initiation signal penetrating at least a part of the medium or the human or animal subject and 2) an insertion device having an electronics assembly unit. The assembly unit includes 1) an emitter configured to emit the wavelength of energy of a predetermined type to treat a disease or disorder in the human or animal subject or to produce a change in the medium and 2) a receiver that receives the signal.

公开(公告)号：US20240042233A1

公开(公告)日：2024-02-08

申请号：US18360187

申请日：2023-07-27

Applicant: Immunolight, LLC ,  DUKE UNIVERSITY

Inventor： Harold WALDER ,  Frederic A. BOURKE, JR. ,  Zakaryae FATHI ,  Wayne F. BEYER, JR. ,  Mark DEWHIRST ,  Mark OLDHAM ,  Justus ADAMSON ,  Michael NOLAN

IPC: A61N5/06 ,  A61K41/17 ,  A61K39/00 ,  A61K41/00 ,  A61K49/04 ,  A61N5/02 ,  A61N5/10

CPC classification number: A61N5/062 ,  A61K41/17 ,  A61K39/0011 ,  A61K41/0066 ,  A61K49/0423 ,  A61N5/022 ,  A61N5/10 ,  A61N5/1081 ,  A61K2039/585 ,  A61N2005/0627 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1089 ,  A61N2005/1098

Abstract: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

公开(公告)号：US20220159998A1

公开(公告)日：2022-05-26

申请号：US17650997

申请日：2022-02-14

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. BOURKE, JR. ,  Zakaryae FATHI ,  Harold WALDER ,  Wayne F. BEYER, JR.

IPC: A23L3/28 ,  A23L3/26 ,  A61L2/08 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  A61M1/34 ,  C23C16/458

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US20180271121A1

公开(公告)日：2018-09-27

申请号：US15895231

申请日：2018-02-13

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. BOURKE, JR. ,  Zakaryae FATHI ,  Harold WALDER ,  Wayne F. BEYER, JR.

IPC: A23L3/28 ,  A61L2/00 ,  A61M1/36 ,  A61N5/06 ,  C02F1/32 ,  C23C16/458 ,  G03F7/20 ,  A23L3/26 ,  A61L2/08

Abstract: A phosphor composition, containing one or more phosphors having on a surface thereof a coating selected from silica, diamond, and diamond-like carbon, wherein the one or more phosphors are configured to emit radiation upon interaction with an initiation energy.