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    Cephalosporin C acylase
    3.
    发明授权
    Cephalosporin C acylase 失效
    头孢菌素C酰基转移酶

    公开(公告)号：US5320948A

    公开(公告)日：1994-06-14

    申请号：US935312

    申请日：1992-08-26

    申请人： Morita Iwami ,  Ichiro Aramori ,  Masao Fukagawa ,  Takao Isogai ,  Hitoshi Kojo

    发明人： Morita Iwami ,  Ichiro Aramori ,  Masao Fukagawa ,  Takao Isogai ,  Hitoshi Kojo

    IPC分类号： C12N1/21 ,  C12N9/80 ,  C12N15/09 ,  C12N15/56 ,  C12P35/04 ,  C12P35/06 ,  C12R1/19 ,  C12R1/38 ,  C12P35/00 ,  C12P21/02

    CPC分类号： C12N9/80 ,  C12P35/04

    摘要： A cephalosporin C acylase from Pseudomonas diminuta N-176 is characterized by its ability to catalyze the conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin, N-benzoylcephalosporin C and cephalothin into 7-aminocephalosporanic acid. The enzyme contains an .alpha.-subunit having a molecular weight of 26 kDA and a .beta.-subunit having a molecular weight of 58 kDa. A method for the recombinant production of the present cephalosporin C acylase in Escherichia coli is provided.

    摘要翻译： 来自假单胞菌N-176的头孢菌素C酰基转移酶的特征在于其能够催化头孢菌素C，戊二酰7-ACA，己二酰基7-ACA，琥珀酰基7-ACA，N-乙酰头孢菌素，N-苯甲酰头孢菌素C和头孢噻吩转化为7 - 氨基头孢烷酸。 该酶含有分子量为26kDA的α亚基和分子量为58kDa的β亚基。 提供了在大肠杆菌中重组生产本发明头孢菌素C酰基转移酶的方法。

    ISOFORMS OF NUCLEAR RECEPTOR RXR a
    6.
    发明申请
    ISOFORMS OF NUCLEAR RECEPTOR RXR a 审中-公开
    核受体RXR的ISOFORMS a

    公开(公告)号：US20050203283A1

    公开(公告)日：2005-09-15

    申请号：US10507696

    申请日：2003-03-25

    申请人： Hitoshi Kojo ,  Kaoru Tajima ,  Masao Fukagawa ,  Shintaro Nishimura ,  Takao Isogai

    发明人： Hitoshi Kojo ,  Kaoru Tajima ,  Masao Fukagawa ,  Shintaro Nishimura ,  Takao Isogai

    IPC分类号： C07K14/705 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  A01K67/00 ,  C07H21/04 ,  C07K14/72 ,  C12N15/09

    CPC分类号： C07K14/70567

    摘要： The present invention relates to the novel isoforms, RXRα2 and RXRα3, of nuclear receptor RXRα. Unlike known isoform RXRα1, the transcriptional activation functions of RXRα2 and RXRα3 are augmented by SRC-1. The present invention provides methods for evaluating the function of regulating augmentation by co-activators of these RXRα isoforms, and screening methods based on these evaluation methods. By controlling the interaction between isoforms and co-activators, transcription-controlling activity can be regulated in an isoform-specific manner.

    摘要翻译： 本发明涉及核受体RXRα的新型异构体RXRalpha2和RXRalpha3。 与已知同种型RXRalpha1不同，RXRalpha2和RXRalpha3的转录激活功能被SRC-1增强。 本发明提供了通过这些RXRα同种型的共激活剂来评价调节功能的方法以及基于这些评价方法的筛选方法。 通过控制异构体和共激活物之间的相互作用，转录调控活性可以以异构体特异性方式调节。

    Nuclear receptor err y 3
    7.
    发明申请
    Nuclear receptor err y 3 审中-公开
    核受体错误3

    公开(公告)号：US20060148030A1

    公开(公告)日：2006-07-06

    申请号：US10507700

    申请日：2003-03-25

    申请人： Hitoshi Kojo ,  Kaoru Tajima ,  Masao Fukagawa ,  Shintaro Nishimura ,  Takao Isogai

    发明人： Hitoshi Kojo ,  Kaoru Tajima ,  Masao Fukagawa ,  Shintaro Nishimura ,  Takao Isogai

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/72

    CPC分类号： C07K14/70567 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/6897 ,  G01N33/6875 ,  G01N2333/70567 ,  G01N2333/723 ,  G01N2500/00

    摘要： The present invention relates to novel nuclear receptor ERRγ3. Although ERRγ3 itself lacks a DNA binding domain, it comprises the function of enhancing the transcriptional activation function of arbitrary nuclear receptors, such as ERR, ER, or TR. Moreover, the present inventors found that, like ERRγ3, the known proteins ERRγ1 and ERRγ2 also comprise the function of enhancing the transcriptional activation function of other nuclear receptors. Thus, the present invention provides methods for evaluating the regulatory function of these ERRγ subtypes in enhancing the transcriptional activation function of other nuclear receptors, and screening methods based on these evaluation methods.

    摘要翻译： 本发明涉及新的核受体ERRγAM3。 尽管ERRgamma3本身缺乏DNA结合结构域，但其包含增强任意核受体如ERR，ER或TR的转录激活功能的功能。 此外，本发明人发现，与ERRγAM3一样，已知蛋白质ERRgamma1和ERRgamma2还包含增强其他核受体的转录激活功能的功能。 因此，本发明提供了用于评估这些ERRγ亚型在增强其他核受体的转录激活功能中的调节功能的方法，以及基于这些评价方法的筛选方法。

    Loading/discarding acquired data for vector load instruction upon determination of prediction success of multiple preceding branch instructions
    8.
    发明授权
    Loading/discarding acquired data for vector load instruction upon determination of prediction success of multiple preceding branch instructions 有权
    在确定多个先前分支指令的预测成功之后，加载/丢弃用于向量加载指令的获取数据

    公开(公告)号：US08850167B2

    公开(公告)日：2014-09-30

    申请号：US13240614

    申请日：2011-09-22

    申请人： Masao Fukagawa

    发明人： Masao Fukagawa

    IPC分类号： G06F9/38 ,  G06F17/16 ,  G06F9/30

    CPC分类号： G06F9/38 ,  G06F9/30036 ,  G06F9/30043 ,  G06F9/3859 ,  G06F17/16

    摘要： Provided is a processor including an instruction issue unit that issues a vector load instruction read from a main memory based on branch target prediction of a branch target in a branch instruction, a data acquisition unit that starts issue of a plurality of acquisition requests for acquiring a plurality of vector data based on the issued vector load instruction from the main memory, a determination unit that determines a success or a failure of the branch target prediction after the branch target is determined, and a vector load management unit that, when the branch target prediction is determined to be a success, acquires all vector data based on the plurality of acquisition requests and then transfers all the vector data to a vector register, and, when the branch target prediction is determined to be a failure, discards the vector data acquired by the issued acquisition requests.

    摘要翻译： 提供了一种处理器，包括：指令发布单元，其基于分支指令中的分支目标的分支目标预测发出从主存储器读取的向量加载指令;数据获取单元，其开始发出多个获取请求， 基于来自主存储器的所发出的矢量加载指令的多个向量数据，确定分支目标确定之后的分支目标预测的成功或失败的确定单元;以及矢量负载管理单元，当分支目标 确定预测成功，基于多个获取请求获取所有矢量数据，然后将所有矢量数据传送到向量寄存器，并且当分支目标预测被确定为故障时，丢弃所获取的矢量数据 由发出的收购要求。

    Processor for managing latest speculation states and efficiently reusing reorder buffer entries
    10.
    发明授权
    Processor for managing latest speculation states and efficiently reusing reorder buffer entries 有权
    用于管理最新投机状态的处理器，并有效地重用重新排序缓冲区条目

    公开(公告)号：US06938150B2

    公开(公告)日：2005-08-30

    申请号：US10040392

    申请日：2002-01-09

    申请人： Masao Fukagawa

    发明人： Masao Fukagawa

    IPC分类号： G06F9/38 ,  G06F9/00

    CPC分类号： G06F9/3836 ,  G06F9/3838 ,  G06F9/384 ,  G06F9/3842 ,  G06F9/3855 ,  G06F9/3861

    摘要： By using an entry number (WRB number) of a re-order buffer 6, each of function units such as an operation unit 3, a store unit 4, a load unit 5, etc. notifies to the re-order buffer 6 the processing end for a instruction stored in the entry concerned in the unit thereof. The load unit 5 manages the latest speculation state of a load instruction issued on the basis of a branch prediction success/failure signal output from the branch unit 2, and makes no notification to the re-order buffer 6 on the basis of WRB number for subsequent load instructions of a branch-prediction failed branch instruction even when the processing of the instruction is finished. Accordingly, the re-order buffer 6 can re-use entries in which the subsequent instructions of the branch prediction failed branch instruction are stored.

    摘要翻译： 通过使用重新排序缓冲器6的入口号（WRB号），诸如操作单元3，存储单元4，加载单元5等功能单元中的每个功能单元向重新排序缓冲器6通知处理 结束存储在其单元中的相关条目中的指令。 负载单元5管理基于从分支单元2输出的分支预测成功/失败信号而发出的加载指令的最新推测状态，并且根据WRB号不向重新排序缓冲器6发送通知 即使当指令的处理结束时，分支预测失败分支指令的后续加载指令。 因此，重新排序缓冲器6可以重新使用存储分支预测失败分支指令的后续指令的条目。