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公开(公告)号：US20180185840A1
公开(公告)日：2018-07-05
申请号：US15841113
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： James Christopher Blake , Umberto Ulmanella , Bradley Kent Drews , Michael Dai Wang , Stephen Wayne Clark , Michael Adalbert Niziolek
Abstract: Disclosed herein are devices and techniques for providing for enhanced fluid mixing in a sample vial. A plunger head may be removably housed inside of a cap that is attached to a container; the cap may have an opening allowing a shaft, e.g., a probe or sipper shaft, to be inserted into the cap and into the plunger head. The shaft may be used to push the plunger head free of the cap, and then to reciprocate the plunger head within the container to mix the content. Withdrawal of the shaft may then cause the plunger head to disengage from the shaft and remain in the container.
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公开(公告)号：US10830784B2
公开(公告)日：2020-11-10
申请号：US15846885
申请日：2017-12-19
Applicant: Illumina, Inc.
Inventor： Johanna L. Whitacre , Steven S. Phelps , Bradley Kent Drews , Debra Sue Bryan, II , Michael A. Niziolek , Joshua A. Darland , Umberto Ulmanella , Michael Dai Wang , Michelle L. Alvarez , Stephen Wayne Clark
IPC: G01N35/10 , G01N35/00 , B01L3/00 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08 , B01F13/10 , C12Q1/6874 , B01F15/00 , B01L3/02 , B01F11/00
Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
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公开(公告)号：US11192105B2
公开(公告)日：2021-12-07
申请号：US16827391
申请日：2020-03-23
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing.
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公开(公告)号：US20180188141A1
公开(公告)日：2018-07-05
申请号：US15841098
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , James Michael Osmus , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
IPC: G01N1/38 , G01N1/14 , B01L3/00 , G01N35/10 , C12Q1/6874 , B01F13/10 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08
CPC classification number: G01N1/38 , B01F3/0861 , B01F3/088 , B01F5/0065 , B01F5/0647 , B01F11/0074 , B01F13/1055 , B01F15/00876 , B01F15/0243 , B01F15/0283 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/502738 , B01L3/52 , B01L3/527 , B01L2200/027 , B01L2200/16 , B01L2300/0832 , B01L2300/0877 , B01L2300/0883 , B01L2400/0644 , C12Q1/6874 , G01N1/14 , G01N35/1002 , G01N35/1016 , G01N35/1095 , G01N35/1097 , G01N2001/1418 , G01N2001/1436 , G01N2001/386 , G01N2035/1058
Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
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公开(公告)号：US12072343B2
公开(公告)日：2024-08-27
申请号：US17062288
申请日：2020-10-02
Applicant: Illumina, Inc.
Inventor： Johanna L. Whitacre , Steven S. Phelps , Bradley Kent Drews , Debra Sue Bryan, II , Michael A. Niziolek , Joshua A. Darland , Umberto Ulmanella , Michael Dai Wang , Michelle L. Alvarez , Stephen Wayne Clark
IPC: G01N35/10 , B01F23/40 , B01F23/45 , B01F25/10 , B01F25/433 , B01F31/65 , B01F33/84 , B01F35/53 , B01F35/71 , B01F35/75 , B01L3/00 , B01L3/02 , C12Q1/6874 , G01N35/00 , B01F101/23
CPC classification number: G01N35/1016 , B01F23/45 , B01F23/49 , B01F25/103 , B01F25/4331 , B01F31/651 , B01F33/84 , B01F35/53 , B01F35/7176 , B01F35/7544 , B01L3/0293 , B01L3/502 , B01L3/527 , C12Q1/6874 , G01N35/00584 , G01N35/1002 , G01N35/1097 , B01F2101/23 , B01L2200/0621 , B01L2200/16 , B01L2300/06 , B01L2300/0867 , B01L2300/0883 , B01L2400/0487 , B01L2400/0622 , B01L2400/0633 , B01L2400/086 , G01N2035/1058
Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
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Patent Agency Ranking
公开(公告)号：US20210270708A1
公开(公告)日：2021-09-02
申请号：US17303043
申请日：2021-05-19
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , James Michael Osmus , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
IPC: G01N1/38 , B01L3/00 , G01N35/10 , C12Q1/6874 , B01F13/10 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08 , G01N1/14 , B01F11/00 , B01F15/00
Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
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公开(公告)号：US11016008B2
公开(公告)日：2021-05-25
申请号：US15841098
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , James Michael Osmus , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
IPC: G01N1/38 , G01N1/14 , B01L3/00 , G01N35/10 , C12Q1/6874 , B01F13/10 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08 , B01F11/00 , B01F15/00
Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.
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公开(公告)号：US20180185842A1
公开(公告)日：2018-07-05
申请号：US15841102
申请日：2017-12-13
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01F11/0074 , B01F13/0059 , B01F15/0258 , B01L3/50273 , B01L3/502738 , B01L3/52 , B01L2200/027 , B01L2200/14 , B01L2200/16 , B01L2300/0832 , B01L2300/0877 , B01L2300/0883 , B01L2400/04 , B01L2400/0622 , B01L2400/0644 , C12Q1/6869 , G01N35/1002 , G01N35/1097 , G01N2035/00881 , G01N2035/1034 , C12Q2565/629
Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing
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公开(公告)号：US20210018527A1
公开(公告)日：2021-01-21
申请号：US17062288
申请日：2020-10-02
Applicant: Illumina, Inc.
Inventor： Johanna L. Whitacre , Steven S. Phelps , Bradley Kent Drews , Debra Sue Bryan, II , Michael A. Niziolek , Joshua A. Darland , Umberto Ulmanella , Michael Dai Wang , Michelle L. Alvarez , Stephen Wayne Clark
IPC: G01N35/10 , G01N35/00 , B01L3/00 , B01F15/02 , B01F5/00 , B01F5/06 , B01F3/08 , B01F13/10 , C12Q1/6874 , B01F15/00 , B01L3/02 , B01F11/00
Abstract: A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.
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公开(公告)号：US20200230598A1
公开(公告)日：2020-07-23
申请号：US16827391
申请日：2020-03-23
Applicant: Illumina, Inc.
Inventor： Bradley Kent Drews , Michael Dai Wang , Umberto Ulmanella , Stephen Wayne Clark , Johanna Lynn Whitacre , Steven Scott Phelps , Michelle L. Alvarez , Michael Adalbert Niziolek , Debra Sue Bryan , Joshua Augustin Darland
Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel. For this, the reagents may be aspirated from a recipient into the volume or channel, ejected back into the recipient, and this process may be performed repeatedly to enhance mixing
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