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    LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS RELATED TO SAME
    1.
    发明申请
    LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS RELATED TO SAME 有权

    公开(公告)号：US20250137930A1

    公开(公告)日：2025-05-01

    申请号：US19010514

    申请日：2025-01-06

    Applicant: Illumina, Inc.

    Inventor： Xiuyu CAI ,  Joseph Francis PINTO ,  Thomas A. BAKER ,  Tracy Helen FUNG

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N21/05 ,  G01N33/58 ,  G02B6/42 ,  H10F39/00 ,  H10F39/10 ,  H10F77/00 ,  H10F77/30 ,  H10F77/40

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

    TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME
    2.
    发明申请
    TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME 审中-公开

    公开(公告)号：US20190196108A1

    公开(公告)日：2019-06-27

    申请号：US16208949

    申请日：2018-12-04

    Applicant: Illumina, Inc.

    Inventor： Xiuyu CAI

    IPC: G02B6/293 ,  G02B5/20 ,  F21V8/00 ,  G01N33/48

    CPC classification number: G02B6/29368 ,  G01J2001/448 ,  G01N21/6454 ,  G01N33/48 ,  G01N2021/0325 ,  G02B5/20 ,  G02B6/0026

    Abstract: Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

    TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME
    5.
    发明申请
    TWO-FILTER LIGHT DETECTION DEVICES AND METHODS RELATED TO SAME 审中-公开

    公开(公告)号：US20200264376A1

    公开(公告)日：2020-08-20

    申请号：US15929503

    申请日：2020-05-06

    Applicant: Illumina, Inc.

    Inventor： Xiuyu CAI

    IPC: G02B6/293 ,  G01N33/48 ,  F21V8/00 ,  G02B5/20 ,  G01N21/64

    Abstract: Light detection devices and corresponding methods are provided. The devices include a reaction structure to contain a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment with the reaction solution. The devices also include a plurality of light sensors and device circuitry. The devices further include a plurality of light guides extending toward at least one corresponding light sensor from input regions that receive the excitation light and the light emissions from at least one corresponding reaction recess. The light guides comprise a first filter region that filters the excitation light and permits the light emissions of a first wavelength to pass to the at least one corresponding light sensor, and a second filter region that filters the excitation light and the permits light emissions of a second wavelength to pass to the at least one corresponding light sensor.

    FLOW CELL SYSTEMS AND METHODS RELATED TO SAME
    7.
    发明公开
    FLOW CELL SYSTEMS AND METHODS RELATED TO SAME 审中-公开

    公开(公告)号：US20230191391A1

    公开(公告)日：2023-06-22

    申请号：US18166023

    申请日：2023-02-08

    Applicant: Illumina, Inc.

    Inventor： Arnaud RIVAL ,  Ali AGAH ,  Dietrich DEHLINGER ,  Tracy H. FUNG ,  Xiuyu CAI

    IPC: B01L3/00 ,  G01N21/05 ,  G01N21/64

    CPC classification number: B01L3/502 ,  G01N21/05 ,  G01N21/6428 ,  B01L2300/0663 ,  G01N2021/6439 ,  B01L2300/042

    Abstract: Flow cells systems and corresponding methods are provided. The flow cells systems may include a socket comprising a base portion, a plurality of electrical contacts and a cover portion that includes a first port. The flow cells systems may also include a flow cell device secured within an enclosure of the socket. The flow cell device may comprise a frameless light detection device comprising a base wafer portion, a plurality of dielectric layers, a reaction structure, a plurality of light guides, a plurality of light sensors, and device circuitry electrically coupled to the light sensors. The flow cell device may also comprise a lid forming a flow channel over the reaction structure that includes a second port in communication with the flow channel and the first port of the socket. The device circuitry of the light detection device may be electrically coupled to the electrical contacts of the socket.

    LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS RELATED TO SAME
    8.
    发明申请
    LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS RELATED TO SAME 有权

    公开(公告)号：US20230125640A1

    公开(公告)日：2023-04-27

    申请号：US18145105

    申请日：2022-12-22

    Applicant: Illumina, Inc.

    Inventor： Xiuyu CAI ,  Joseph Francis PINTO ,  Thomas A. BAKER ,  Tracy Helen FUNG

    IPC: G01N21/64 ,  B01L3/00 ,  G01J1/44 ,  G01N33/58 ,  G02B6/42 ,  H01L27/144 ,  H01L27/146 ,  H01L31/02 ,  H01L31/0216 ,  H01L31/0232

    Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

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