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公开(公告)号：US10252996B2
公开(公告)日：2019-04-09
申请号：US15841971
申请日：2017-12-14
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/16 , C07D211/70
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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公开(公告)号：US11572341B2
公开(公告)日：2023-02-07
申请号：US16820860
申请日：2020-03-17
发明人： Hong Woo Kim , Jae Kap Jeong , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Sung Wuk Kim
IPC分类号： C07C279/26 , C07D211/10 , C07D211/34 , A61K31/155 , A61P35/00
摘要： The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.
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公开(公告)号：US20170073331A1
公开(公告)日：2017-03-16
申请号：US15304798
申请日：2015-04-17
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee , Mi Jeong Kim , Woong Cho
IPC分类号： C07D403/12 , C07C311/47 , C07D295/13 , C07D211/14 , C07D319/18 , C07D333/20 , C07D251/18 , C07D249/14 , C07D211/54 , C07C279/04 , C07C279/08 , C07D209/44 , C07C279/16 , C07C279/06 , C07D233/91 , C07D213/38 , C07C279/12 , C07D239/42 , C07C279/24 , C07D207/16 , C07D277/46 , C07D263/48 , C07C279/26
CPC分类号： C07D403/12 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/12 , C07C279/16 , C07C279/24 , C07C279/26 , C07C311/47 , C07C311/49 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/16 , C07D209/40 , C07D209/44 , C07D211/14 , C07D211/54 , C07D213/38 , C07D213/40 , C07D233/88 , C07D233/91 , C07D239/42 , C07D249/14 , C07D251/18 , C07D251/48 , C07D263/48 , C07D277/46 , C07D295/13 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
摘要翻译： 本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍化合物及其应用。 更具体地，本发明涉及通过抑制线粒体氧化磷酸化和重新编程细胞代谢来预防或治疗OXPHOS相关疾病，特别是癌症的药物组合物。
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公开(公告)号：US10058558B2
公开(公告)日：2018-08-28
申请号：US14893433
申请日：2014-05-20
发明人： Sung Wuk Kim , Soon Im Lee , Yeon Jung Song , Min Jae Shin , Kook Hwan Oh , Kyung Don Ju , Eun Kyoung Shin , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Min Jeong Kim , Hye Soun Eum
IPC分类号： A61K31/165 , A61K31/55 , A61K31/155 , C07C279/26 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445
CPC分类号： A61K31/55 , A61K31/155 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445 , C07C279/26
摘要： The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.
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5.发明申请PHARMACEUTICAL COMPOSITION COMPRISING N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES AS AN INGREDIENT FOR PREVENTING OR TREATING FIBROSIS 审中-公开包含N1循环胺-N5取代的双胍衍生物作为预防或治疗纤维化成分的药物组合物公开(公告)号：US20160101112A1
公开(公告)日：2016-04-14
申请号：US14893433
申请日：2014-05-20
发明人： Sung Wuk Kim , Soon Im Lee , Yeon Jung Song , Min Jae Shin , Kook Hwan Oh , Kyung Don Ju , Eun Kyoung Shin , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Min Jeong Kim , Hye Soun Eum
IPC分类号： A61K31/55 , A61K31/44 , A61K31/397 , A61K31/445 , A61K31/40
CPC分类号： A61K31/55 , A61K31/155 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445 , C07C279/26
摘要： The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.
摘要翻译： 本发明提供了N1环胺-N5取代双胍衍生物用于制备预防或治疗纤维化的药物的新用途。 根据本发明的N1环胺-N5取代双胍衍生物能够通过有效地抑制EMT而有效地抑制纤维化。
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公开(公告)号：US10590081B2
公开(公告)日：2020-03-17
申请号：US15569584
申请日：2015-04-30
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee
IPC分类号： C07D295/215 , C07D211/38 , C07C279/26 , C07D221/20 , C07D207/10 , C07D277/04 , C07D209/52 , A61K31/155 , A61K31/40 , A61K45/06 , A61K31/44
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
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公开(公告)号：US20190144464A1
公开(公告)日：2019-05-16
申请号：US16244721
申请日：2019-01-10
发明人： Hong Woo Kim , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Jae Kap Jeong , Ji Hyun Park , Seo-il Kim , Young Woo Lee
IPC分类号： C07D495/04 , C07D241/04 , C07D401/12 , C07D405/12 , C07D207/16 , C07D211/60
摘要： The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.
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公开(公告)号：US10221190B2
公开(公告)日：2019-03-05
申请号：US14528468
申请日：2014-10-30
发明人： Hong Woo Kim , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Jae Kap Jeong , Ji Hyun Park , Seo-il Kim , Young Woo Lee
IPC分类号： C07D207/16 , C07D211/60 , C07D241/04 , C07D401/12 , C07D495/04 , C07D405/12
摘要： The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.
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公开(公告)号：US11465989B2
公开(公告)日：2022-10-11
申请号：US15304798
申请日：2015-04-17
发明人： Sung Wuk Kim , Hong Woo Kim , Sang Hee Yoo , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Young Woo Lee , Mi Jeong Kim , Woong Cho
IPC分类号： C07D295/13 , C07D213/38 , C07D213/40 , C07D333/20 , C07D333/16 , C07D249/14 , C07D251/18 , C07D251/48 , C07D211/14 , C07D211/54 , C07D209/44 , C07D209/40 , C07D233/88 , C07D233/91 , C07D207/46 , C07D279/08 , C07D203/12 , C07D239/42 , C07D263/48 , C07D319/18 , C07D317/58 , C07D277/46 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P5/50 , A61P13/00 , A61P21/00 , A61P35/00 , A61P35/04 , A61P9/00 , A61P19/10 , A61P1/16 , A61P15/00 , C07C279/16 , C07C311/47 , C07C311/49 , C07C279/12 , C07C279/26 , C07C279/24 , C07C279/08 , C07C279/04 , C07C279/06 , C07D403/12 , C07D207/16
摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
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公开(公告)号：US09884821B2
公开(公告)日：2018-02-06
申请号：US14766203
申请日：2014-02-06
发明人： Chang Hee Min , Yong Eun Kim , Byung Kyu Oh , Ji Sun Lee , Hye Jin Heo , Ju Hoon Oh , Woong Cho
IPC分类号： C07D207/20 , C07D211/14 , C07D211/70 , C07D211/16
CPC分类号： C07D211/70 , C07D207/20 , C07D211/14 , C07D211/16
摘要： The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
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