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公开(公告)号：US06900232B2
公开(公告)日：2005-05-31
申请号：US09882186
申请日：2001-06-15
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D213/72
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译： 本发明涉及由式I表示的一类化合物，其中A 1是下式的吡啶基，其任选被一个或多个选自下组的R 0选自 羟基，烷基，烷氧基，烷氧基烷基，硫代烷基，卤代烷基，氰基，氨基烷基氨基，卤素，酰氨基，磺酰胺和-COR; 且R为羟基，烷氧基，烷基或氨基; 和其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α3β3和/或α / 5> 5＆lt; 5＆gt;整联蛋白。
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公开(公告)号：US06949578B2
公开(公告)日：2005-09-27
申请号：US10891361
申请日：2004-07-14
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/415 , A61K31/4172 , C07D233/38
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α
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3.发明授权公开(公告)号：US06921767B2
公开(公告)日：2005-07-26
申请号：US10326299
申请日：2002-12-20
申请人： Nagarajan R. Srinivasan , Ish Kumar Khanna , Michael Clare , Alan Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu , Yu Yi , Renee M. Huff , Bipinchandra N. Desai , Balekudru Devadas , Mihir D. Parikh , Thomas Penning
发明人： Nagarajan R. Srinivasan , Ish Kumar Khanna , Michael Clare , Alan Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu , Yu Yi , Renee M. Huff , Bipinchandra N. Desai , Balekudru Devadas , Mihir D. Parikh , Thomas Penning
IPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D239/14 , A61K31/505 , A61P9/10 , A61P19/10
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α
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公开(公告)号：US06833366B1
公开(公告)日：2004-12-21
申请号：US10657932
申请日：2003-09-09
申请人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
发明人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
IPC分类号： A61K3133
CPC分类号： C07D213/74 , C07D239/14 , C07D401/12
摘要： The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
摘要翻译： 本发明涉及一类由式1表示的化合物或其药学上可接受的盐，包含式1的化合物的药物组合物，以及选择性抑制或拮抗阿尔法博三唑和/或阿尔法肽5整联蛋白的方法。
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公开(公告)号：US06720315B2
公开(公告)日：2004-04-13
申请号：US09882137
申请日：2001-06-15
申请人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan , Heather Stenmark
发明人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan , Heather Stenmark
IPC分类号： A61K3133
CPC分类号： C07D213/74 , C07D239/14 , C07D401/12
摘要： The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译： 本发明涉及一类由式1表示的化合物或其药学上可接受的盐，包含式1化合物的药物组合物和选择性抑制或拮抗αVβ3和/或αVbeta5整联蛋白的方法。
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公开(公告)号：US06531494B1
公开(公告)日：2003-03-11
申请号：US09942214
申请日：2001-08-29
申请人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
发明人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/73 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白的方法。
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公开(公告)号：US07119098B2
公开(公告)日：2006-10-10
申请号：US10311385
申请日：2001-06-15
申请人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara B. Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark L. Boys , Nizal S. Chandrakumar , Hwang-Fun Lu
发明人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara B. Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark L. Boys , Nizal S. Chandrakumar , Hwang-Fun Lu
IPC分类号： C07D403/12 , C07D403/14 , C07D401/12 , A61K31/443 , A61K31/4375
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the ανβ5 integrin without significantly antagonizing the IIb/IIIa integrin.
摘要翻译： 本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐，包含式（I）化合物的药物组合物，和选择性拮抗化合物3和/或 在不显着拮抗IIb / IIIa整联蛋白的情况下，所述的5'-整联蛋白。
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公开(公告)号：US06933304B2
公开(公告)日：2005-08-23
申请号：US09881913
申请日：2001-06-15
申请人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
发明人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
IPC分类号： A61K31/4245 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07D213/74 , C07D231/38 , C07D233/60 , C07D233/88 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/04
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the αVβ3 and/or the αVβ5 integrin without significantly antagonizing the IIb/IIIa or αVβ6 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性拮抗α-β3 和/或α5AT55整联蛋白，而不显着拮抗IIb / IIIa或α5β6 / SUB>整合素。
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公开(公告)号：US5852210A
公开(公告)日：1998-12-22
申请号：US825080
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
IPC分类号： A61K31/00 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/275 , A61K31/277 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/54 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/14 , A61P19/00 , A61P19/10 , A61P35/00 , A61P35/04 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D231/06 , C07D233/50 , C07D233/54 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12 , C07C241/00 , C07C205/00 , C07D233/44 , C07D239/02
CPC分类号： C07D231/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D233/50 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。
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公开(公告)号：US20110086074A1
公开(公告)日：2011-04-14
申请号：US12995711
申请日：2009-06-02
申请人： Pradeep Jairao Karatgi , Thilek Kumar Muniyappan , Shantanu Yeshwant Damle , Sesha Sai Marella , Harshal Prabhakar Bhagwatwar , Raviraj Sukumar Pillai , Ish Kumar Khanna
发明人： Pradeep Jairao Karatgi , Thilek Kumar Muniyappan , Shantanu Yeshwant Damle , Sesha Sai Marella , Harshal Prabhakar Bhagwatwar , Raviraj Sukumar Pillai , Ish Kumar Khanna
IPC分类号： A61K31/549 , A61K9/00 , A61P29/00 , A61P3/06 , A61P3/10
CPC分类号： A61K31/455 , A61K9/2081 , A61K9/209 , A61K9/2886 , A61K9/5026 , A61K9/5073 , A61K9/5084 , A61K31/54 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical formulations comprising a combination of niacin and an oxicam NSAID, for oral administration, and methods of preparing the formulations.
摘要翻译： 包含烟酸和奥昔康NSAID的组合用于口服给药的药物制剂和制备该制剂的方法。
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