公开(公告)号：US08086412B2

公开(公告)日：2011-12-27

申请号：US12457730

申请日：2009-06-19

申请人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

发明人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

IPC分类号： G01N33/48 ,  G06F19/00

CPC分类号： G06F19/20 ,  G06F19/24

摘要： A corrective method is described for processing results of transcriptome experiments obtained by differential analysis includes the following steps: obtaining the results of the level of expression of genes under a reference condition, and calculating the mean level of expression of each of such genes; obtaining the results of the level of expression of such genes under a treatment condition, and calculating the mean level of expression for each of such genes; calculating the modulation coefficient for the level of expression for each of such genes; calculating a p-value associated with each modulation coefficient; and calculating isobar curves of p-value as a function of the mean level of expression of each of such genes under the reference condition; calculating and associating a median modulation coefficient on the isobar curve of each p-value observed. The processing of results of experiments carried out on DNA chips is also described.

摘要翻译： 描述了通过差异分析获得的转录组实验处理结果的校正方法，包括以下步骤：获得参考条件下基因表达水平的结果，并计算每个这样的基因的平均表达水平; 在治疗条件下获得这些基因表达水平的结果，并计算每个这样的基因的平均表达水平; 计算每个这样的基因的表达水平的调节系数; 计算与每个调制系数相关联的p值; 并计算p值的等压曲线作为参考条件下每个这样的基因的平均表达水平的函数; 计算和关联每个p值的等压曲线上的中值调制系数。 还描述了对DNA芯片进行的实验结果的处理。

公开(公告)号：US20100057369A1

公开(公告)日：2010-03-04

申请号：US12457730

申请日：2009-06-19

申请人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

发明人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

IPC分类号： G06F19/00

CPC分类号： G06F19/20 ,  G06F19/24

摘要： A corrective method for processing results of transcriptome experiments obtained by differential analysis includes the following steps: obtaining the results of the level of expression of genes under a reference condition, and calculating the mean level of expression of each of such genes; obtaining the results of the level of expression of such genes under a treatment condition, and calculating the mean level of expression for each of such genes; calculating the modulation coefficient for the level of expression for each of such genes; calculating a p-value associated with each modulation coefficient; and calculating isobar curves of p-value as a function of the mean level of expression of each of such genes under the reference condition; calculating and associating a median modulation coefficient on the isobar curve of each p-value observed; this method applies in particular to the processing of results of experiments carried out on DNA chips.

摘要翻译： 通过差异分析获得的转录组实验处理结果的校正方法包括以下步骤：获得参考条件下基因表达水平的结果，并计算各基因的平均表达水平; 在治疗条件下获得这些基因表达水平的结果，并计算每个这样的基因的平均表达水平; 计算每个这样的基因的表达水平的调节系数; 计算与每个调制系数相关联的p值; 并计算p值的等压曲线作为参考条件下每个这样的基因的平均表达水平的函数; 计算和关联每个p值的等压曲线上的中值调制系数; 该方法特别适用于对DNA芯片进行的实验结果的处理。

公开(公告)号：US20110268742A1

公开(公告)日：2011-11-03

申请号：US12991093

申请日：2009-05-07

申请人： Jérôme Aubert ,  Sophie Deret ,  Isabelle Carlavan ,  Michel Rivier

发明人： Jérôme Aubert ,  Sophie Deret ,  Isabelle Carlavan ,  Michel Rivier

IPC分类号： A61K39/395 ,  G01N33/566 ,  C12Q1/02 ,  A61P17/08 ,  C07H21/04 ,  C07K16/18 ,  A61P17/10 ,  C12Q1/68 ,  C07K14/47

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/10 ,  G01N2800/20

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the phosphatidylcholine transfer protein (PCTP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节磷脂酰胆碱转运的表达或活性的能力 蛋白质（PCTP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20110213009A1

公开(公告)日：2011-09-01

申请号：US12991329

申请日：2009-05-07

申请人： Jérôme Aubert ,  Sophie Deret ,  Valérie Trinquet

发明人： Jérôme Aubert ,  Sophie Deret ,  Valérie Trinquet

IPC分类号： A61K31/713 ,  C12Q1/68 ,  C07H21/04 ,  C40B30/04 ,  G01N33/53 ,  C07H21/02 ,  A61K31/56 ,  A61P17/00 ,  A61P17/10 ,  A61P17/08

CPC分类号： G01N33/566 ,  C12N15/1086 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6881 ,  G01N2800/20 ,  G01N2800/202 ,  G01N2800/56

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the adipose differentiation-related protein (ADFP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与超星球症相关的皮肤病症的体外或体内方法包括测定化合物调节脂肪分化的表达或活性的能力 相关蛋白（ADFP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20110189686A1

公开(公告)日：2011-08-04

申请号：US12991168

申请日：2009-05-07

申请人： Michel Rivier ,  Isabelle Carlavan ,  Jérôme Aubert

发明人： Michel Rivier ,  Isabelle Carlavan ,  Jérôme Aubert

IPC分类号： C12Q1/68 ,  C12Q1/32 ,  C12Q1/26 ,  C12N9/04 ,  C12N9/02 ,  C07H21/00

CPC分类号： G01N33/5008 ,  G01N33/5735 ,  G01N2333/80 ,  G01N2333/90245 ,  G01N2333/904 ,  G01N2500/10 ,  G01N2800/20

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the CYP2B15 and/or glycerol-3-phosphate dehydrogenase 1 (GPD1) proteins.

摘要翻译： 用于筛选候选化合物以预防或治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤病症的体外或体内方法包括测定化合物调节CYP2B15的表达或活性的能力，以及 /或甘油-3-磷酸脱氢酶1（GPD1）蛋白。

公开(公告)号：US20110150773A1

公开(公告)日：2011-06-23

申请号：US12991060

申请日：2009-05-07

申请人： Jérôme Aubert ,  Michel Rivier ,  Johannes Voegel

发明人： Jérôme Aubert ,  Michel Rivier ,  Johannes Voegel

IPC分类号： A61K49/00 ,  G01N33/53 ,  C12Q1/68 ,  A61K39/395 ,  C07H21/00 ,  C12N9/10 ,  A61P17/08 ,  A61P17/10

CPC分类号： G01N33/6893 ,  G01N2333/91057 ,  G01N2500/10 ,  G01N2800/20

摘要： An in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of acetyl-coenzyme A acyltransferase 1 (ACAA1) or of acetyl-coenzyme A acyltransferase 2 (ACAA2), and also utilizes modulators of the expression or of the activity of either of these enzymes, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外方法包括测定化合物调节乙酰辅酶A酰基转移酶1的表达或活性的能力 （ACAA1）或乙酰辅酶A酰基转移酶2（ACAA2），并且还利用这些酶的表达或活性的调节剂用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20130017969A1

公开(公告)日：2013-01-17

申请号：US13516834

申请日：2010-12-16

申请人： Jérôme Aubert ,  Martin Steinhoff ,  Michel Rivier ,  Johannes Voegel

发明人： Jérôme Aubert ,  Martin Steinhoff ,  Michel Rivier ,  Johannes Voegel

IPC分类号： C40B30/04 ,  A61B10/02

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： Markers for rosacea among the chemokines and cytokines and their receptors, selected from interleukin 8 (IL-8), CXCL1, CXCL2, CXCL3 and CXCL5, the CXCR1 receptor and the CXCR2 receptor are described. Also described, is a method for the diagnosis of rosacea.

摘要翻译： 描述了选自白介素8（IL-8），CXCL1，CXCL2，CXCL3和CXCL5，CXCR1受体和CXCR2受体的趋化因子和细胞因子及其受体中的红斑痤疮的标志物。 还描述了用于诊断酒渣鼻的方法。

公开(公告)号：US20110263677A1

公开(公告)日：2011-10-27

申请号：US12990995

申请日：2009-05-07

申请人： Jérôme Aubert ,  Isabelle Carlavan ,  Johannes Voegel

发明人： Jérôme Aubert ,  Isabelle Carlavan ,  Johannes Voegel

IPC分类号： A61K31/713 ,  C12Q1/68 ,  A61P17/08 ,  C07H21/02 ,  C07H21/04 ,  G01N33/566 ,  C12Q1/02

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of G0/G1 switch protein 2 (GOS2), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节G0 / G1的表达或活性的能力 开关蛋白2（GOS2），并且还利用这种蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与超球囊相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20110165168A1

公开(公告)日：2011-07-07

申请号：US12991254

申请日：2009-05-07

申请人： Jérôme Aubert ,  Pascale Reiniche ,  Michel Rivier ,  Johannes Voegel

发明人： Jérôme Aubert ,  Pascale Reiniche ,  Michel Rivier ,  Johannes Voegel

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/53 ,  C07H21/00 ,  C07K2/00 ,  C07K16/18 ,  A61P17/10 ,  A61P17/08

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/6872 ,  G01N2500/00 ,  G01N2800/20 ,  G01N2800/202

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the CIDEA protein, and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与超星球症相关的皮肤病症的体外或体内方法包括测定化合物调节CIDEA蛋白质的表达或活性的能力 ，并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20110262451A1

公开(公告)日：2011-10-27

申请号：US12991178

申请日：2009-05-07

申请人： Jérôme Aubert ,  Tony Minier ,  Valérie Trinquet ,  Michel Rivier

发明人： Jérôme Aubert ,  Tony Minier ,  Valérie Trinquet ,  Michel Rivier

IPC分类号： A61K39/395 ,  C12Q1/32 ,  G01N33/573 ,  A61P17/08 ,  C07H21/04 ,  C07K16/40 ,  A61P17/10 ,  C12Q1/68 ,  C12N9/02

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/136 ,  G01N2333/90206 ,  G01N2500/10 ,  G01N2800/20

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of isovaleryl-coenzyme A dehydrogenase (IVD), and also utilizes modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节异戊酰辅酶的表达或活性的能力 脱氢酶（IVD），并且还利用该酶的表达或活性的调节剂用于治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。