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1.发明申请CIDEA MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开CIDEA调节器治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA公开(公告)号：US20110165168A1
公开(公告)日：2011-07-07
申请号：US12991254
申请日：2009-05-07
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C07H21/00 , C07K2/00 , C07K16/18 , A61P17/10 , A61P17/08
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6872 , G01N2500/00 , G01N2800/20 , G01N2800/202
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the CIDEA protein, and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与超星球症相关的皮肤病症的体外或体内方法包括测定化合物调节CIDEA蛋白质的表达或活性的能力 ，并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。
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2.发明申请MODULATORS OF ACETYL-COENZYME A ACYLTRANSFERASE 1 OR 2 IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开乙酰苯胺的调节剂ACYLTRANSFERASE 1或2治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA公开(公告)号：US20110150773A1
公开(公告)日：2011-06-23
申请号：US12991060
申请日：2009-05-07
申请人： Jérôme Aubert , Michel Rivier , Johannes Voegel
发明人： Jérôme Aubert , Michel Rivier , Johannes Voegel
IPC分类号： A61K49/00 , G01N33/53 , C12Q1/68 , A61K39/395 , C07H21/00 , C12N9/10 , A61P17/08 , A61P17/10
CPC分类号： G01N33/6893 , G01N2333/91057 , G01N2500/10 , G01N2800/20
摘要： An in vitro method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of acetyl-coenzyme A acyltransferase 1 (ACAA1) or of acetyl-coenzyme A acyltransferase 2 (ACAA2), and also utilizes modulators of the expression or of the activity of either of these enzymes, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外方法包括测定化合物调节乙酰辅酶A酰基转移酶1的表达或活性的能力 （ACAA1）或乙酰辅酶A酰基转移酶2（ACAA2），并且还利用这些酶的表达或活性的调节剂用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。
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公开(公告)号：US20130017969A1
公开(公告)日：2013-01-17
申请号：US13516834
申请日：2010-12-16
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： Markers for rosacea among the chemokines and cytokines and their receptors, selected from interleukin 8 (IL-8), CXCL1, CXCL2, CXCL3 and CXCL5, the CXCR1 receptor and the CXCR2 receptor are described. Also described, is a method for the diagnosis of rosacea.
摘要翻译： 描述了选自白介素8（IL-8），CXCL1，CXCL2，CXCL3和CXCL5，CXCR1受体和CXCR2受体的趋化因子和细胞因子及其受体中的红斑痤疮的标志物。 还描述了用于诊断酒渣鼻的方法。
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4.发明申请MODULATORS OF MONOGLYCERIDE LIPASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开单核细胞脂质体在ACNE，SEBORRHOEIC DERMATITIS或HYPERSEBORRHOEA治疗中的调节剂公开(公告)号：US20110262450A1
公开(公告)日：2011-10-27
申请号：US12991088
申请日：2009-05-07
申请人： Pascale Reiniche , Michel Rivier
发明人： Pascale Reiniche , Michel Rivier
IPC分类号： A61K39/395 , C12Q1/68 , A61P17/10 , C07K16/40 , C07H21/04 , C12N9/16 , C12Q1/44 , G01N33/566
CPC分类号： G01N33/6881 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2333/4724 , G01N2333/92 , G01N2800/20
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of monoglyceride lipase (MGLL), and also utilizes modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤病症的体外或体内方法包括测定化合物调节甘油单酯脂肪酶的表达或活性的能力（ MGLL），并且还利用该酶的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。
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公开(公告)号：US20100099689A1
公开(公告)日：2010-04-22
申请号：US12562665
申请日：2009-09-18
申请人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/425 , A61K31/506 , A61K31/44 , A61P17/00
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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6.发明授权Compounds that modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof 失效调节PPARγ型受体的化合物和包含它们的化妆品/药物组合物公开(公告)号：US07625914B2
公开(公告)日：2009-12-01
申请号：US11311449
申请日：2005-12-20
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/445 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/415 , A61K31/38 , A61K31/34 , C07D239/02 , C07D211/06 , C07D213/00 , C07D285/10 , C07D277/20 , C07D249/14 , C07D233/28 , C07D333/36 , C07D307/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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7.发明申请SCREENING FOR MODULATORS OF CYP2B15 AND/OR GPD1 FOR THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开CYP2B15和/或GPD1调节剂的筛选用于治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA公开(公告)号：US20110189686A1
公开(公告)日：2011-08-04
申请号：US12991168
申请日：2009-05-07
申请人： Michel Rivier , Isabelle Carlavan , Jérôme Aubert
发明人： Michel Rivier , Isabelle Carlavan , Jérôme Aubert
CPC分类号： G01N33/5008 , G01N33/5735 , G01N2333/80 , G01N2333/90245 , G01N2333/904 , G01N2500/10 , G01N2800/20
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the CYP2B15 and/or glycerol-3-phosphate dehydrogenase 1 (GPD1) proteins.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤病症的体外或体内方法包括测定化合物调节CYP2B15的表达或活性的能力，以及 /或甘油-3-磷酸脱氢酶1（GPD1）蛋白。
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8.发明申请Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds 失效调节PPARγ型受体的化合物和包含所述化合物的化妆品/药物组合物公开(公告)号：US20100247468A1
公开(公告)日：2010-09-30
申请号：US12585634
申请日：2009-09-21
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K8/49 , C07D417/10 , A61K31/427 , A61P17/14 , A61P35/00 , A61Q19/00 , A61Q5/00 , A61P17/10 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/02 , A61P9/10 , A61P9/12 , A61P11/06 , C07D333/24 , A61K31/381 , C07D213/75 , A61K31/4418 , C07D249/14 , A61K31/4196 , C07D213/56
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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9.发明申请PCTP MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA的PCTP调节剂公开(公告)号：US20110268742A1
公开(公告)日：2011-11-03
申请号：US12991093
申请日：2009-05-07
申请人： Jérôme Aubert , Sophie Deret , Isabelle Carlavan , Michel Rivier
发明人： Jérôme Aubert , Sophie Deret , Isabelle Carlavan , Michel Rivier
IPC分类号： A61K39/395 , G01N33/566 , C12Q1/02 , A61P17/08 , C07H21/04 , C07K16/18 , A61P17/10 , C12Q1/68 , C07K14/47
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2500/10 , G01N2800/20
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the phosphatidylcholine transfer protein (PCTP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节磷脂酰胆碱转运的表达或活性的能力 蛋白质（PCTP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。
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10.发明申请MODULATORS OF ISOVALERYL-COENZYME A DEHYDROGENASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开ISO L Y EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA EA公开(公告)号：US20110262451A1
公开(公告)日：2011-10-27
申请号：US12991178
申请日：2009-05-07
申请人： Jérôme Aubert , Tony Minier , Valérie Trinquet , Michel Rivier
发明人： Jérôme Aubert , Tony Minier , Valérie Trinquet , Michel Rivier
IPC分类号： A61K39/395 , C12Q1/32 , G01N33/573 , A61P17/08 , C07H21/04 , C07K16/40 , A61P17/10 , C12Q1/68 , C12N9/02
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , G01N2333/90206 , G01N2500/10 , G01N2800/20
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of isovaleryl-coenzyme A dehydrogenase (IVD), and also utilizes modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节异戊酰辅酶的表达或活性的能力 脱氢酶（IVD），并且还利用该酶的表达或活性的调节剂用于治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。
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