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公开(公告)号：US06350892B1
公开(公告)日：2002-02-26
申请号：US09507782
申请日：2000-02-18
IPC分类号： C07F704
CPC分类号： C07D207/08 , C07C17/269 , C07C25/18 , C07C45/515 , C07C45/673 , C07C45/74 , C07C49/245 , C07C49/248 , C07C49/255 , C07C69/63 , C07C69/712 , C07C69/738 , C07C217/22 , C07C229/12 , C07C233/18 , C07C235/20 , C07C311/04 , C07C317/18 , C07C323/12 , C07D207/12 , C07D207/16 , C07D211/14 , C07D211/46 , C07D215/14 , C07D231/12 , C07D271/06 , C07D277/04 , C07D311/20 , C07D313/08 , C07D317/34 , C07F7/1804 , C07F9/113 , C07F9/2458
摘要： Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where (R′), p, D, Y, Z, Ra, Rb and A are as defined in the specification.
摘要翻译： 提供cPLA2酶的选择性抑制剂，其可用于控制多种炎性疾病。 本发明的抑制剂具有通式（R'），p，D，Y，Z，Ra，Rb和A如说明书中所定义。
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公开(公告)号：US06255496B1
公开(公告)日：2001-07-03
申请号：US09300111
申请日：1999-04-27
IPC分类号： C07D20708
CPC分类号： C07D207/08 , C07C17/269 , C07C25/18 , C07C45/515 , C07C45/673 , C07C45/74 , C07C49/245 , C07C49/248 , C07C49/255 , C07C69/63 , C07C69/712 , C07C69/738 , C07C217/22 , C07C229/12 , C07C233/18 , C07C235/20 , C07C311/04 , C07C317/18 , C07C323/12 , C07D207/12 , C07D207/16 , C07D211/14 , C07D211/46 , C07D215/14 , C07D231/12 , C07D271/06 , C07D277/04 , C07D311/20 , C07D313/08 , C07D317/34 , C07F7/1804 , C07F9/113 , C07F9/2458
摘要： Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula
摘要翻译： 提供cPLA2酶的选择性抑制剂，其可用于控制多种炎性疾病。 本发明的抑制剂具有通式
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公开(公告)号：US09938291B2
公开(公告)日：2018-04-10
申请号：US14775546
申请日：2014-03-13
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D498/04 , C07D213/79 , C07D249/04 , C07D237/28 , C07D471/08 , C07D237/24 , C07D487/04 , C07C233/56 , C07D213/80 , C07D231/56 , C07D239/28 , C07D471/04 , C07D491/052
CPC分类号： C07D498/04 , C07C233/56 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07D239/28 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20160368925A1
公开(公告)日：2016-12-22
申请号：US15254966
申请日：2016-09-01
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3r R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
摘要翻译： 或其药学上可接受的盐。
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公开(公告)号：US08795782B2
公开(公告)日：2014-08-05
申请号：US13355072
申请日：2012-01-20
IPC分类号： C09D201/02 , C08L101/02
CPC分类号： C08J7/16 , C08F2438/03
摘要： The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerization initiators and a plurality of surface binding groups. Pendant polymers may be grafted from at least some of the polymerization initiators.
摘要翻译： 本发明涉及一种可控制的聚合物表面涂层，其包括共价结合到基底表面的大分子，该大分子包括多个聚合引发剂和多个表面结合基团。 侧链聚合物可以从至少一些聚合引发剂接枝。
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6.发明申请公开(公告)号：US20120083495A1
公开(公告)日：2012-04-05
申请号：US13310965
申请日：2011-12-05
申请人： Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
发明人： Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
IPC分类号： A61K31/5377 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D405/10 , A61K31/4035 , A61K31/4439 , A61K31/506 , A61K31/454 , A61K31/403 , C12N5/071 , A61P25/16 , A61P25/28 , A61P25/00 , A61P25/08 , A61P35/00 , A61P3/10 , A61P21/00 , A61P31/12 , C07D209/46
CPC分类号： C07D209/46 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Compounds useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
摘要翻译： 可用于治疗脊髓性肌萎缩或其他用途的化合物，以及使用这些化合物增加SMN表达，增加EAAT2表达或增加编码通过突变或移码引入的翻译终止密码子的核酸的表达的方法。
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7.发明授权公开(公告)号：US08110681B2
公开(公告)日：2012-02-07
申请号：US12293268
申请日：2007-03-13
申请人： Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
发明人： Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
IPC分类号： C07D413/04 , C07D239/24 , C07D401/04 , C07D209/46 , C07D206/56 , A61K31/535 , A61K31/44 , A61K31/40 , A01N43/54
CPC分类号： C07D209/46 , C07D401/04 , C07D403/04 , C07D409/04
摘要： Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
摘要翻译： 可用于治疗脊髓性肌萎缩或其他用途的式（I）或（II）化合物，以及使用这些化合物增加SMN表达的方法，增加EAAT2表达，或增加编码 通过突变或移码引入的翻译终止密码子。
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公开(公告)号：US20080029167A1
公开(公告)日：2008-02-07
申请号：US11826289
申请日：2007-07-13
申请人： Carol Norma Eastwick , Kathryn Anne Simmons , Graham Johnson , Stephen John Pickering , Mark Farrall
发明人： Carol Norma Eastwick , Kathryn Anne Simmons , Graham Johnson , Stephen John Pickering , Mark Farrall
IPC分类号： F16C1/24
CPC分类号： F01D25/186 , F01D25/125 , F01D25/16 , F05D2240/50 , F16C19/06 , F16C33/6685 , F16C2360/23 , Y10T137/85938
摘要： A flow control arrangement 10 for controlling the flow of lubricant discharged from a bearing 12 includes a flow control member 24 locatable, in use, adjacent to the bearing 12. The flow control member 24 defines a generally circumferential outer edge 26a and is rotatable to direct lubricant discharged onto the flow control member 24 radially outwardly towards the outer edge 26a for ejection therefrom.
摘要翻译： 用于控制从轴承12排出的润滑剂的流动的流量控制装置10包括在使用中可与轴承12相邻定位的流量控制构件24。 流量控制构件24限定大致圆周的外边缘26a，并且可旋转以将排出到流量控制构件24上的润滑剂径向向外朝向外边缘26a排出以从其中弹出。
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公开(公告)号：US20070023715A1
公开(公告)日：2007-02-01
申请号：US11265668
申请日：2005-11-02
申请人： Gary Ross , Graham Johnson , Barrie Clark , Simon Forrest
发明人： Gary Ross , Graham Johnson , Barrie Clark , Simon Forrest
CPC分类号： C03C12/00 , C03C3/095 , G06K9/00577 , G06K9/2018
摘要： A method of identifying a source of a marking fluid applied to a person or an object comprises applying a marking fluid including one or more security markers to a person or an object and illuminating the applied marking fluid to excite the security markers. Photoluminescent emission from the security markers in response to the excitation is measured and compared with one or more pre-defined photoluminescent signatures associated with the source of the marking fluid. The source of the marking fluid is identified based on a match between the detected photoluminescent emission and at least one of the pre-defined photoluminescent signatures.
摘要翻译： 识别施用于人或物体的标记液的源的方法包括将包括一个或多个安全标记的标记流体施加到人或物体，并照亮所施加的标记液以激发安全标记。 测量响应于激发的来自安全标记物的光致发光，并将其与与标记液源相关联的一个或多个预定义的光致发光标记进行比较。 基于检测到的光致发光发射与至少一个预定义的光致发光标记之间的匹配来识别标记液的来源。
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公开(公告)号：US5973089A
公开(公告)日：1999-10-26
申请号：US776997
申请日：1997-12-22
IPC分类号： G02C7/04 , A61L27/00 , C08F290/06 , C08F299/02 , C08G18/28 , C08G18/48 , C08G18/50 , C08G18/73 , C08G18/81 , C08G65/32 , G02B1/04 , C08F16/24
CPC分类号： C08G18/8116 , C08F290/062 , C08G18/283 , C08G18/4833 , C08G18/5015 , C08G18/73 , G02B1/043
摘要： Macromonomers of the formula I are described:Q-B(L-B).sub.n T (I)wherein n is at least 1.0;Q is a polymerizable group;B may be the same or different and is a difunctional block of molecular weight in the range of from 100 to 4000 and wherein at least one B is a perfluorinated polyether of formula II;--OCH.sub.2 CF.sub.2 O(CF.sub.2 CF.sub.2 O).sub.x (CF.sub.2 O).sub.y CF.sub.2 CH.sub.2 O-- (II)wherein the CF.sub.2 CF.sub.2 O and CF.sub.2 O units may be randomly distributed or distributed as blocks throughout the chain and wherein x and y may be the same or different such that the molecular weight of the perfluorinated polyether is in the range of from 242 to 4,000;L is a difunctional linking group; andT is a terminal group.These macromonomers may be used in the production of contact lenses, corneal implants, cell growth substrate or medical implant.
摘要翻译： PCT No.PCT / EP96 / 01256 Sec。 371 1997年12月22日第 102（e）日期1997年12月22日PCT 1996年3月22日PCT公布。 出版物WO96 / 31545 日期：1996年10月10日描述式I的共聚单体：其中n为至少1.0的Q-B（L-B）nT（I） Q是可聚合基团; B可以相同或不同，是分子量在100-4000范围内的二官能嵌段，其中至少一个B是式II的全氟化聚醚; -OCH 2 CF 2 O（CF 2 CF 2 O）x（CF 2 O）y CF 2 CH 2 O-（II ），其中CF 2 CF 2 O和CF 2 O单元可以作为整个链中的嵌段无规分布或分布，并且其中x和y可以相同或不同，使得全氟聚醚的分子量在242至4000的范围内; L是双官能连接基团; T是终端组。 这些大分子单体可用于制造隐形眼镜，角膜植入物，细胞生长底物或医用植入物。
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