公开(公告)号：US09515083B2

公开(公告)日：2016-12-06

申请号：US14723296

申请日：2015-05-27

申请人： Jae-Eun Lee ,  Sunghoon Kim

发明人： Jae-Eun Lee ,  Sunghoon Kim

IPC分类号： G11C16/08 ,  H01L27/115

CPC分类号： H01L27/11582 ,  G11C16/08 ,  H01L23/5226 ,  H01L23/528 ,  H01L23/535 ,  H01L24/05 ,  H01L27/11568 ,  H01L27/1157 ,  H01L27/11573 ,  H01L2224/0235 ,  H01L2224/02381 ,  H01L2224/04042 ,  H01L2224/05093 ,  H01L2224/05569 ,  H01L2224/05571 ,  H01L2224/056 ,  H01L2924/10252 ,  H01L2924/10253 ,  H01L2924/10329 ,  H01L2924/10335 ,  H01L2924/1434 ,  H01L2924/1438 ,  H01L2924/1443 ,  H01L2924/145 ,  H01L2924/1451 ,  H01L2924/14511 ,  H01L2924/00012

摘要： A nonvolatile memory device includes a memory cell array including a plurality of memory cells, a first metal layer, a peripheral circuit configured to control the memory cell array, a second metal layer, and a pad. The first metal layer is disposed on the memory cell array and includes a plurality of cell region interconnections connected to the memory cell array. The second metal layer is disposed on the peripheral circuit and includes a plurality of peripheral region interconnections connecting the peripheral circuit and the plurality of cell region interconnections. The pad is disposed on the second metal layer and exchanges data, an address, or a command with the peripheral circuit during operation of the device. The second metal layer is lower than the first metal layer relative to a substrate of the device.

摘要翻译： 非易失性存储器件包括包括多个存储单元的存储单元阵列，第一金属层，被配置为控制存储单元阵列的外围电路，第二金属层和衬垫。 第一金属层设置在存储单元阵列上，并且包括连接到存储单元阵列的多个单元区域互连。 第二金属层设置在外围电路上，并且包括连接外围电路和多个单元区域互连的多个周边区域互连。 焊盘设置在第二金属层上，并在设备的操作期间与外围电路交换数据，地址或命令。 第二金属层相对于器件的衬底低于第一金属层。

公开(公告)号：US10130611B2

公开(公告)日：2018-11-20

申请号：US13465709

申请日：2012-05-07

申请人： Sunghoon Kim ,  Jin Woo Choi ,  Jin Young Lee ,  Dae Gyu Kim ,  Gyoon Hee Han ,  Jee Sun Yang ,  Chul Ho Lee

发明人： Sunghoon Kim ,  Jin Woo Choi ,  Jin Young Lee ,  Dae Gyu Kim ,  Gyoon Hee Han ,  Jee Sun Yang ,  Chul Ho Lee

IPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428

摘要： This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.

公开(公告)号：US10068913B2

公开(公告)日：2018-09-04

申请号：US15633941

申请日：2017-06-27

申请人： Jaeick Son ,  Sunghoon Kim

发明人： Jaeick Son ,  Sunghoon Kim

IPC分类号： H01L29/06 ,  H01L47/00 ,  H01L27/11573 ,  G11C13/00 ,  G11C16/30 ,  H01L23/528 ,  H01L27/11524 ,  H01L27/11529 ,  H01L27/11556 ,  H01L27/1157 ,  H01L27/11582 ,  H01L27/24 ,  H01L29/94

CPC分类号： H01L27/11573 ,  G11C13/0038 ,  G11C16/30 ,  H01L23/5286 ,  H01L27/11524 ,  H01L27/11529 ,  H01L27/11556 ,  H01L27/11565 ,  H01L27/1157 ,  H01L27/11575 ,  H01L27/11582 ,  H01L27/2436 ,  H01L27/2454 ,  H01L27/249 ,  H01L29/94

摘要： A three-dimensional semiconductor device includes a semiconductor substrate including a cell array region and a peripheral circuit region, an electrode structure including electrodes vertically stacked on the cell array region, a MOS capacitor on the peripheral circuit region, an interlayer dielectric layer covering the electrode structure and the MOS capacitor, first and second power lines spaced apart from each other in a first direction and extending in a second direction on the interlayer dielectric layer, first lower plugs connected to the first power line and a first terminal of the MOS capacitor, and second lower plugs connected to the second power line to a second terminal of the MOS capacitor. The second power line is on one of the first lower plugs that is adjacent to some of the second lower plugs in one of the first and second directions.

公开(公告)号：US08784300B2

公开(公告)日：2014-07-22

申请号：US13364876

申请日：2012-02-02

申请人： Olajire Idowu ,  Sunghoon Kim

发明人： Olajire Idowu ,  Sunghoon Kim

IPC分类号： A61B1/00

CPC分类号： A61B1/00094 ,  A61B1/00165 ,  A61B1/05 ,  A61M27/00 ,  A61M2250/00

摘要： Pleural empyema removal devices are provided and enable the removal of empyema from the pleural cavity of a human or veterinary patient. The pleural empyema removal devices may be coupled with one or more additional devices, such as suction source, gas source, light source and/or camera source, and monitor. The devices and systems including the devices facilitate the removal of empyema from the pleural cavity of a patient while providing protections from damage to untargeted tissues. The devices, systems, and methods can be used in the treatment process to treat pleural empyema resulting from pleural effusions and infections stemming from various illnesses and disorders, such as pneumonia.

摘要翻译： 提供胸膜积液除去装置，并能够从人或兽医患者的胸膜腔中除去脓胸。 胸膜积液除去装置可以与一个或多个附加装置（例如抽吸源，气体源，光源和/或照相机源）和监视器耦合。 包括装置的装置和系统有助于从患者的胸膜腔中除去脓肿，同时提供保护以免对非靶向组织的损伤。 装置，系统和方法可用于治疗由胸膜积液引起的胸膜积液和由各种疾病和疾病如肺炎引起的感染的治疗过程。

公开(公告)号：US08563327B2

公开(公告)日：2013-10-22

申请号：US13198990

申请日：2011-08-05

申请人： Sang Gyu Park ,  Kyong Soo Park ,  Sunghoon Kim

发明人： Sang Gyu Park ,  Kyong Soo Park ,  Sunghoon Kim

IPC分类号： G01N33/564 ,  G01N33/536 ,  G01N33/543 ,  G01N33/573 ,  G01N33/66 ,  C07K16/40

CPC分类号： G01N33/6893 ,  G01N2800/042

摘要： The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.

摘要翻译： 本发明提供了作为1型糖尿病的新型诊断标记物，包含丙氨酰-tRNA合成酶，甘氨酰-tRNA合成酶，天冬酰胺酰-tRNA合成酶或色氨酰-tRNA合成酶的1型糖尿病诊断组合物，其包含 相同，以及使用其的诊断方法。 根据本发明的组合物，试剂盒和方法可以用于1型糖尿病的早期诊断和确认诊断，因为可以容易地从患者样品中诊断1型糖尿病。

公开(公告)号：US20120322802A1

公开(公告)日：2012-12-20

申请号：US13505651

申请日：2010-11-02

申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

IPC分类号： A61K31/505 ,  C07D401/12 ,  A61K31/506 ,  C40B30/04 ,  A61K31/5377 ,  A61P29/00 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12

CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

公开(公告)号：US20120283300A1

公开(公告)日：2012-11-08

申请号：US13465709

申请日：2012-05-07

申请人： Sunghoon Kim ,  Jin Woo Choi ,  Jin Young Lee ,  Dae Gyu Kim ,  Gyoon Hee Han ,  Jee Sun Yang ,  Chul Ho Lee

发明人： Sunghoon Kim ,  Jin Woo Choi ,  Jin Young Lee ,  Dae Gyu Kim ,  Gyoon Hee Han ,  Jee Sun Yang ,  Chul Ho Lee

IPC分类号： A61K31/423 ,  C07D263/57 ,  C07D209/14 ,  A61K31/4045 ,  A61P7/06 ,  A61K31/428 ,  C07D277/66 ,  A61P35/00 ,  A61P35/04 ,  C07D263/58 ,  C07D277/82

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428

摘要： This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.

摘要翻译： 本申请涉及新的苯并杂环衍生物，更具体地说，涉及用于预防和治疗癌症或抑制转移的组合物，其包含苯并杂环衍生物或其药学上可接受的盐作为活性成分。 本发明人证实，KRS通过与67LR相互作用促进癌症（或肿瘤）细胞迁移而对癌症转移有影响，并且还发现抑制KRS和67LR之间的相互作用的物质可以通过抑制癌细胞转移来预防和治疗癌症。 因此，本发明的组合物可以抑制癌症转移，从而提供预防和治疗癌症的新手段。

公开(公告)号：US20120010141A1

公开(公告)日：2012-01-12

申请号：US13155750

申请日：2011-06-08

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： A61K38/18 ,  A61P17/02 ,  A61K38/16

CPC分类号： A61K38/19

摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell re-epithelization, proliferation of fibroblasts or angiogenesis.

摘要翻译： 本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中 组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。 本发明方法中使用的组合物可有效地用于伤口愈合，因为组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有优异的作用 再上皮化，成纤维细胞增殖或血管生成。

公开(公告)号：US08003780B2

公开(公告)日：2011-08-23

申请号：US12255943

申请日：2008-10-22

申请人： Sunghoon Kim ,  Jin Woo Choi

发明人： Sunghoon Kim ,  Jin Woo Choi

IPC分类号： C07H21/04

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57423 ,  G01N33/57438 ,  G01N2500/04

摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer.

摘要翻译： 本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 靶向AIMP2-DX2的AIMP2-DX2基因和siRNA可以成功地用于诊断和治疗癌症。

公开(公告)号：US07282208B2

公开(公告)日：2007-10-16

申请号：US10623567

申请日：2003-07-22

申请人： Sunghoon Kim

发明人： Sunghoon Kim

IPC分类号： A61K38/17 ,  A61K38/18 ,  C07K14/435 ,  C07K14/475

CPC分类号： A61K38/19

摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.

摘要翻译： 本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中 组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。 用于本发明方法的组合物可以有效地用于伤口愈合，因为组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有优异的效果 ，再上皮化，成纤维细胞增殖或血管发生。