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公开(公告)号：US20080142002A1
公开(公告)日：2008-06-19
申请号：US12018716
申请日：2008-01-23
申请人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
IPC分类号： A61M11/00
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.
摘要翻译： 公开了用于间歇递送雾化药物的系统。 该系统可以包括气溶胶发生器，控制器和导管。 气溶胶发生器可以构造成使药物雾化。 控制器可以被配置为接收关于患者的生理特征信息，并且至少部分地基于生理特征信息来控制气溶胶发生器。 导管可以被构造成将雾化的药物供应到患者的气道。
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公开(公告)号：US08196573B2
公开(公告)日：2012-06-12
申请号：US12018716
申请日：2008-01-23
申请人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.
摘要翻译： 公开了用于间歇递送雾化药物的系统。 该系统可以包括气溶胶发生器，控制器和导管。 气溶胶发生器可以构造成使药物雾化。 控制器可以被配置为接收关于患者的生理特征信息，并且至少部分地基于生理特征信息来控制气溶胶发生器。 导管可以被构造成将雾化的药物供应到患者的气道。
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公开(公告)号：US07971588B2
公开(公告)日：2011-07-05
申请号：US11090328
申请日：2005-03-24
申请人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.
摘要翻译： 一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。 另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100μg至约500mg药物的雾化气雾剂。 另外，一种用于治疗肺部疾病的雾化药物，其中药物包含与调节pH约5.5至约6.3的水溶液混合的阿米卡星。 通过向水溶液中加入盐酸和氢氧化钠来调节pH。
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公开(公告)号：US20100126502A1
公开(公告)日：2010-05-27
申请号：US11990587
申请日：2006-08-21
申请人： James B. Fink , Gavan O'Sullivan , Paul Dunne , Declan Moran , John Power , Niall Smith
发明人： James B. Fink , Gavan O'Sullivan , Paul Dunne , Declan Moran , John Power , Niall Smith
IPC分类号： A61M11/00
CPC分类号： A61M16/0833 , A61M11/00 , A61M15/009 , A61M16/0057 , A61M16/08 , A61M16/0875 , A61M16/14 , A61M16/20
摘要： Apparatus (500) and components for coupling fluid or gas conducting elements, such as apparatus and components for connecting a nebulizer (501) with a gas flow system. In particular, the apparatus (500) and components are useful for connecting, in a gas-tight and quick release manner, a nebulizer (501) to a pressure-assisted breathing system, such as a mechanical ventilator or a continuous positive airway pressure (“CPAP”) system.
摘要翻译： 用于耦合流体或气体传导元件的装置（500）和用于将雾化器（501）与气体流动系统连接的装置和部件。 特别地，装置（500）和部件可用于以气密和快速释放的方式将雾化器（501）连接到诸如机械呼吸机或持续正气道压力的压力辅助呼吸系统（501） “CPAP”）系统。
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公开(公告)号：US20050217666A1
公开(公告)日：2005-10-06
申请号：US11090328
申请日：2005-03-24
申请人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.
摘要翻译： 一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。 另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100至500mg药物的雾化气雾剂。 另外，一种用于治疗肺部疾病的雾化药物，其中药物包含与调节pH约5.5至约6.3的水溶液混合的阿米卡星。 通过向水溶液中加入盐酸和氢氧化钠来调节pH。
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公开(公告)号：US20050011514A1
公开(公告)日：2005-01-20
申请号：US10833932
申请日：2004-04-27
申请人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
发明人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebuliser to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebuliser and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebuliser.
摘要翻译： 一种用于递送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气溶胶发生器，其中发生器将至少一部分药物雾化成气溶胶，气体通气入口 允许气体进入雾化器并与气溶胶形成混合物，以及将气溶胶和气体的混合物输送到雾化器的出口的通道。
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公开(公告)号：US08616195B2
公开(公告)日：2013-12-31
申请号：US10833932
申请日：2004-04-27
申请人： John S Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
发明人： John S Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebulizer and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer.
摘要翻译： 一种用于递送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气溶胶发生器，其中发生器将至少一部分药物雾化成气溶胶，气体通气入口 允许气体进入雾化器并与气溶胶形成混合物，以及将气溶胶和气体的混合物输送到喷雾器的出口的通道。
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公开(公告)号：US07331339B2
公开(公告)日：2008-02-19
申请号：US10996994
申请日：2004-11-23
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.
摘要翻译： 包含至少一个识别标记物或标记物的星云可以与气溶胶发生器连接。 识别标记可以由气溶胶发生器上的感测装置感测，以便识别烟雾中的液体到气溶胶发生器的控制器。 气溶胶发生器的控制器可以基于从识别标记读取的信息来控制气溶胶发生器。
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公开(公告)号：US06968840B2
公开(公告)日：2005-11-29
申请号：US10345875
申请日：2003-01-15
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61K9/12 , A61J1/06 , A61K47/04 , A61M15/00 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/08 , B05B15/00 , B05B17/06 , B65D1/09 , B05D7/14 , B05D83/06
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.
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公开(公告)号：US07748377B2
公开(公告)日：2010-07-06
申请号：US11928214
申请日：2007-10-30
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.
摘要翻译： 通过振动雾化元件产生的雾化流体在患者呼吸周期的一定间隔期间被引入呼吸回路中。 在一些实施方案中，流体包含选择用于治疗由机械通气引起的肺部感染的抗生素。
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