公开(公告)号：US4603345A

公开(公告)日：1986-07-29

申请号：US590651

申请日：1984-03-19

申请人： James C. K. Lee ,  Gene M. Amdahl ,  Carlton G. Amdahl ,  Robert J. Beall ,  Anthony Matouk ,  John W. Sliwa ,  Andrzej Kucharek

发明人： James C. K. Lee ,  Gene M. Amdahl ,  Carlton G. Amdahl ,  Robert J. Beall ,  Anthony Matouk ,  John W. Sliwa ,  Andrzej Kucharek

IPC分类号： H01L23/34 ,  H01L23/473 ,  H01L23/50 ,  H01L23/46

CPC分类号： H01L23/473 ,  H01L23/50 ,  H01L2924/0002

摘要： A module for a semiconductor chip is disclosed. The module includes a heat sink with a flat surface to which the back face of the semiconductor chip is directly bonded. The exposed face of the chip has an array of power, ground and signal contacts. A plurality of alternating power and ground bus bars span the exposed face of the chip. A multilayer ceramic is located on the other side of the bus bar array and has a surface proximate the power and ground bus bars with an array of contacts which correspond to at least the signal contacts on the chip. Power leads connect the power bus bars to adjacent power contacts on the chip; ground leads connect the ground bus bars to adjacent ground contacts on the chip; and signal leads pass between adjacent power and ground bus bars and interconnect the signal contacts on the chip with the corresponding signal contacts on the ceramic. A plurality of connectors emanate from the ceramic and are electrically coupled by vias or traces through the ceramic to the signal contacts for the transmission of signals to and from the chip.

摘要翻译： 公开了一种用于半导体芯片的模块。 该模块包括具有平坦表面的散热器，半导体芯片的背面直接粘合在该散热器上。 芯片的暴露面具有电源，接地和信号触点阵列。 多个交流电源和接地母线跨越芯片的暴露面。 多层陶瓷位于母线阵列的另一侧，并且具有靠近电源和接地母线的表面，其具有至少对应于芯片上的信号触点的触点阵列。 电源引线将电源总线连接到芯片上的相邻电源触点; 接地引线将接地母线连接到芯片上的相邻接地触点; 并且信号引线在相邻的电源和接地母线之间通过，并将芯片上的信号触点与陶瓷上的相应信号触点相互连接。 多个连接器从陶瓷发出并且通过陶瓷的通孔或迹线电耦合到信号触头，以将信号传输到芯片和从芯片传输。

公开(公告)号：US08864757B2

公开(公告)日：2014-10-21

申请号：US12347607

申请日：2008-12-31

申请人： Gleb V. Klimovitch ,  John W. Sliwa

发明人： Gleb V. Klimovitch ,  John W. Sliwa

IPC分类号： A61B18/18 ,  A61B18/04 ,  A61B17/42 ,  A61B17/46 ,  A61D1/10 ,  A61B8/00 ,  A61B5/04 ,  A61B18/14 ,  A61B5/00 ,  A61B5/042 ,  A61B18/02 ,  A61B19/00 ,  A61N7/02 ,  A61B18/24

CPC分类号： A61B5/6885 ,  A61B5/042 ,  A61B8/12 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/24 ,  A61B2090/065 ,  A61B2218/002 ,  A61N1/05 ,  A61N7/022

摘要： A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including insulation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.

摘要翻译： 一种接触检测组件，包括导管，其包括具有邻近导管主体的头部安装的基部的电极。 传感器邻近基部设置，用于测量施加到电极末端部分的压缩或拉伸力，并且包括预定的灵敏度。 基部和头部包括预定的刚度，使得施加到电极末端部分的力可以根据灵敏度和传感器输出来确定。 接触检测组件还包括可操作地连接到导管主体的用于与导管主体一起移动和弯曲的电极管，以及设置在电极管中并包括绝缘体的电极线。 在导管弯曲期间由电极线向电极管的移动或电极线与电极管的接触的电容变化与施加于导管的力相关。

公开(公告)号：US07877854B2

公开(公告)日：2011-02-01

申请号：US11958862

申请日：2007-12-18

申请人： John W. Sliwa ,  John P. Goetz ,  Zhenyi Ma

发明人： John W. Sliwa ,  John P. Goetz ,  Zhenyi Ma

IPC分类号： H04R31/00

CPC分类号： G10K11/30 ,  Y10T29/49005 ,  Y10T29/49007 ,  Y10T29/4908 ,  Y10T29/49172 ,  Y10T29/49194

摘要： A focused ultrasound transducer includes a first ultrasonic emitter and at least one metallic ultrasonic lens acoustically coupled thereto. The emitter generates ultrasonic energy that propagates along a beam path projecting therefrom. The at least one metallic ultrasonic lens is positioned at least partially in the beam path so that it can direct (e.g., focus, defocus, and/or collimate) in at least one direction (or along at least one plane) at least some of the ultrasonic energy propagating from the emitter. The metallic lens may be formed by extrusion, by molding (e.g., diecast molding or thermoforming), or by sintering (e.g., powder metallurgy). The metallic lens also advantageously functions as a heat sink, improving thermal performance of the ultrasound transducer.

摘要翻译： 聚焦超声波换能器包括第一超声波发射器和声耦合到其上的至少一个金属超声波透镜。 发射器产生沿着从其突出的光束路径传播的超声波能量。 至少一个金属超声波透镜至少部分地定位在光束路径中，使得其可以在至少一个方向（或沿着至少一个平面）上引导（例如，聚焦，散焦和/或准直）至少一个 超声能量从发射器传播。 金属透镜可以通过挤出，模制（例如，压铸模塑或热成型）或通过烧结（例如粉末冶金）形成。 金属透镜还有利地用作散热器，从而改善超声换能器的热性能。

公开(公告)号：US20100233021A1

公开(公告)日：2010-09-16

申请号：US12381423

申请日：2009-03-11

申请人： John W. Sliwa ,  George W. Keilman ,  Bryan T. Oronsky ,  Carol A. Tosaya ,  Herbert L. Berman

发明人： John W. Sliwa ,  George W. Keilman ,  Bryan T. Oronsky ,  Carol A. Tosaya ,  Herbert L. Berman

IPC分类号： A61L2/10 ,  A61L2/03 ,  A61L2/025 ,  A61N1/32

CPC分类号： A61M25/0017 ,  A61B90/70 ,  A61M27/00 ,  A61M37/00 ,  A61M2025/0019 ,  A61N1/205 ,  A61N1/32 ,  A61N1/40

摘要： Disclosed are methods of inhibiting, avoiding or destroying existing, potential or incipient biodeposits, biofilms or pathogens any of (a) in or on a living body including in or on a medical device or implement placed, inserted or insertable in the body, (b) in, on or in contact with an ex vivo bodily tissue or fluid, or (c) in, on or in contact with a medium or matter to be consumed, ingested by or exposed to a living being or entity. Also disclosed are medical devices, implements, and prostheses that can be kept in a safe defouled, pathogen-free or pathogen-reduced condition with the help of an electric field(s). Also disclosed are medical or industrial devices, implements, equipment-articles and storage/handling-entities that can be kept in a safely defouled, pathogen-free or pathogen-reduced condition with the help of a membrane or orifice that has one or more of the antifouling or antipathogenic attributes.

摘要翻译： 公开了抑制，避免或破坏现有的，潜在的或初期的生物沉积物，生物膜或病原体（a）在生物体内或之上的生物体，包括在放置，插入或插入体内的医疗装置或器具中或之上，（b） ）在离体身体组织或流体接触或接触时，或（c）在要消费的介质或物质中或与其接触或摄入或暴露于活体或实体时。 还公开了医疗装置，器具和假体，其可以在电场的帮助下保持在安全的防污染，无病原体或病原体减少的状态。 还公开了医疗或工业装置，器具，设备制品和储存/处理实体，其可以在具有一个或多个以下的膜或孔的帮助下保持在安全脱钩，无病原体或病原体减少的状态 防污或抗病原性。

公开(公告)号：US20100168620A1

公开(公告)日：2010-07-01

申请号：US12347607

申请日：2008-12-31

申请人： Gleb V. Klimovitch ,  John W. Sliwa

发明人： Gleb V. Klimovitch ,  John W. Sliwa

IPC分类号： A61B5/00

CPC分类号： A61B5/6885 ,  A61B5/042 ,  A61B8/12 ,  A61B18/02 ,  A61B18/1492 ,  A61B18/24 ,  A61B2090/065 ,  A61B2218/002 ,  A61N1/05 ,  A61N7/022

摘要： A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including isolation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.

摘要翻译： 一种接触检测组件，包括导管，其包括具有邻近导管主体的头部安装的基部的电极。 传感器邻近基部设置，用于测量施加到电极末端部分的压缩或拉伸力，并且包括预定的灵敏度。 基部和头部包括预定的刚度，使得施加到电极尖端部分的力可以作为灵敏度和传感器输出的函数来确定。 接触检测组件还包括可操作地连接到导管主体的电极管，用于与导管主体一起移动和弯曲，以及设置在电极管中并包括隔离的电极线。 在导管弯曲期间由电极线向电极管的移动或电极线与电极管的接触的电容变化与施加于导管的力相关。

公开(公告)号：US20100168569A1

公开(公告)日：2010-07-01

申请号：US12346132

申请日：2008-12-30

申请人： John W. Sliwa ,  Stephen A. Morse

发明人： John W. Sliwa ,  Stephen A. Morse

IPC分类号： A61B8/00 ,  A61B18/14

CPC分类号： A61B8/12 ,  A61B8/00 ,  A61B8/0841 ,  A61B8/4245 ,  A61B8/445 ,  A61B8/463 ,  A61B18/02 ,  A61B18/14 ,  A61B18/18 ,  A61B18/20 ,  A61B2090/3782 ,  A61B2090/3784 ,  A61N7/02 ,  A61N7/022

摘要： An ablation system comprises a tool including an shaft having proximal and distal end portions, a handle at the proximal end portion, and a lumen extending between the proximal and distal end portions. The system further includes an ablation subsystem comprised of an ablation element at the distal end portion of the shaft, and an ablation source connected to the ablation element. The system further includes an imaging subsystem comprising an ultrasound imaging transducer disposed proximate the ablation element. The transducer is pivotally attached to the shaft or the ablation element to allow the transducer to articulate between stowed and deployed positions. The imaging subsystem further comprises a processor connected to the transducer configured to receive image data acquired by the transducer, and to generate an image corresponding thereto. The imaging subsystem still further includes a display connected to the processor configured to display the generated image.

摘要翻译： 消融系统包括工具，其包括具有近端部分和远端部分的轴，在近端部分处的手柄以及在近端部分和远端部分之间延伸的内腔。 该系统还包括消融子系统，其包括在轴的远端部分处的消融元件和连接到消融元件的消融源。 该系统还包括成像子系统，其包括邻近消融元件设置的超声成像换能器。 换能器枢转地附接到轴或消融元件，以允许换能器在收起位置和展开位置之间铰接。 成像子系统还包括连接到换能器的处理器，其被配置为接收由换能器获取的图像数据，并且生成与其对应的图像。 成像子系统还包括连接到处理器的显示器，其被配置为显示生成的图像。

公开(公告)号：US20090163836A1

公开(公告)日：2009-06-25

申请号：US11963784

申请日：2007-12-21

申请人： John W. Sliwa

发明人： John W. Sliwa

IPC分类号： A61N7/00 ,  A61H1/00

CPC分类号： A61N7/02 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00642 ,  A61N2007/0056

摘要： The invention discloses a system for delivering acoustic energy to a subject in connection with high intensity focused ultrasound (HIFU) systems. In an embodiment, the system comprises an optionally disposable waveguide-attached ablation applicator coupled with an optionally re-usable waveguide, and an optional acoustic power source. The systems may comprise acoustic energy exit port intensity control, waveguide heat-sinking, and transducer operational adjustments that accommodate waveguide effects on the traversing acoustic power.

摘要翻译： 本发明公开了一种用于将声能传递到与高强度聚焦超声（HIFU）系统相关的受试者的系统。 在一个实施例中，系统包括可选地一次性波导附着的消融施涂器，其与可选择地可重复使用的波导和可选的声功率源耦合。 这些系统可以包括声能出口强度控制，波导散热以及适应波导对穿越声功率的影响的换能器操作调整。

公开(公告)号：US20080140026A1

公开(公告)日：2008-06-12

申请号：US12001701

申请日：2007-12-11

申请人： John W. Sliwa ,  Herbert L. Berman ,  Bryan T. Oronsky ,  Carol A. Tosaya

发明人： John W. Sliwa ,  Herbert L. Berman ,  Bryan T. Oronsky ,  Carol A. Tosaya

IPC分类号： A61M35/00

CPC分类号： A61M37/0092 ,  A61M35/00

摘要： An apparatus and method are provided for delivering to a patient's first bodily site and allowing bodily transport therefrom to one or more second bodily sites of a medically, physiologically, neurologically or other health-beneficial species, the at least one species or species precursor which would normally be one or more of volatile, gaseous, vaporous, sublimating, reactive, unacceptably degradable, toxic, hazardous, metastable or unstable if stored in unprotected ambient atmospheric conditions

摘要翻译： 提供了一种装置和方法，用于递送给患者的第一身体部位，并允许从身体转运到医疗，生理学，神经学或其他健康有益物种的一个或多个第二身体部位，所述至少一种物种或物质前体将 通常是一种或多种挥发性，气态，气态，升华，反应性，不可接受的降解，有毒，危险，亚稳或不稳定，如果储存在无保护的环境大气条件

公开(公告)号：US20080033297A1

公开(公告)日：2008-02-07

申请号：US11890027

申请日：2007-08-02

申请人： John W. Sliwa

发明人： John W. Sliwa

IPC分类号： A61B18/00

CPC分类号： A61N7/00 ,  A61B5/0051 ,  A61B5/0059 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/055 ,  A61B5/4041 ,  A61B8/0816 ,  A61N1/40 ,  A61N2/002

摘要： A system is disclosed for the diagnostic or therapeutic treatment of a patient's neural tissues. The system includes at least a means to directly or indirectly acoustically expose or acoustically displace at least a first tissue portion. The system further includes a means to impose, directly or indirectly, an electromagnetic, electrical, magnetic or optical field on at least a second neural tissue portion. The combined or cooperative action of the acoustic exposure/displacement and the field, whether sequentially or simultaneously applied, causes at least one diagnostically or therapeutically useful mechanism. The two tissue portions may be the same portion or different portions.

摘要翻译： 公开了用于诊断或治疗患者神经组织的系统。 该系统至少包括直接或间接声学地暴露或声学地移位至少第一组织部分的装置。 该系统还包括在至少第二神经组织部分上直接或间接施加电磁，电，磁或光场的装置。 声学暴露/位移和场的组合或协同作用，无论是依次还是同时施用，都会导致至少一种诊断或治疗有用的机制。 两个组织部分可以是相同的部分或不同部分。

公开(公告)号：US06645145B1

公开(公告)日：2003-11-11

申请号：US09962427

申请日：2001-09-24

申请人： William R. Dreschel ,  Terry Kling ,  John W. Sliwa ,  Stuart L. Carp ,  Sevig Ayter

发明人： William R. Dreschel ,  Terry Kling ,  John W. Sliwa ,  Stuart L. Carp ,  Sevig Ayter

IPC分类号： A61B800

CPC分类号： B06B1/00 ,  A61B8/445 ,  A61B8/4483 ,  H01H59/0009

摘要： The use of any micro-mechanical component in an ultrasound system is disclosed. In particular, the use of micro-mechanical ultrasound transducers, micro-relays, micro-switches and inductors in the transducer probe head, in the transducer connector, coupled with the system transducer connector(s) or anywhere else in the system. In an ultrasound system, micro-mechanical components such as micro-mechanical ultrasound transducers, micro-fabricated switches, relays and inductors permit impressive size reduction, cost reduction, signal-integrity enhancement and improved operational flexibility.

摘要翻译： 公开了在超声系统中使用任何微机械部件。 特别地，在换能器探头中，在换能器连接器中使用微机械超声换能器，微型继电器，微型开关和电感器，与系统换能器连接器或系统中的任何其他地方相结合。 在超声系统中，诸如微机械超声换能器，微型开关，继电器和电感器的微机械组件允许显着的尺寸减小，成本降低，信号完整性增强和改进的操作灵活性。