Quantitative two-photon flow cytometry
    5.
    发明授权
    Quantitative two-photon flow cytometry 有权
    定量双光子流式细胞术

    公开(公告)号:US08486371B2

    公开(公告)日:2013-07-16

    申请号:US11662835

    申请日:2005-09-16

    IPC分类号: A61K49/00

    摘要: A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.

    摘要翻译: 使用流式细胞仪对颗粒进行多染色分析的方法和装置。 该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒,使得两种或更多种染料各自发荧光,从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。 使用多光子激发激光束激发毛细管内的第二颗粒,使得两种或更多种染料各自发出荧光,从而分别产生第三输出信号和第四输出信号。 该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较,以检测颗粒中期望的变化。

    Burst spread spectrum radio system and method for site monitoring
    6.
    发明授权
    Burst spread spectrum radio system and method for site monitoring 有权
    突发扩频无线电系统和现场监测方法

    公开(公告)号:US07796675B1

    公开(公告)日:2010-09-14

    申请号:US12046950

    申请日:2008-03-12

    IPC分类号: H04B1/00

    摘要: A device for site monitoring is disclosed. The device may include a communication interface configured to receive site monitoring data from a site monitoring system. The communication interface may also be configured to wirelessly transmit the site monitoring data to a base station. The site monitoring data may include a device identification. The device also may include a processor and memory. The memory also may include two pseudonoise (PN) codes, namely a first PN code and a second PN code. The site monitoring data may be received from the site monitoring system. The site monitoring data may be spread using the first PN code to provide first spread site monitoring data. The first spread site monitoring data may be spread using the second PN code to provide second spread site monitoring data. The second spread site monitoring data may be transmitted using a burst direct sequence spread spectrum radio signal.

    摘要翻译: 公开了一种用于现场监控的设备。 该设备可以包括被配置为从站点监视系统接收站点监视数据的通信接口。 通信接口还可以被配置为将站点监视数据无线地发送到基站。 站点监视数据可以包括设备标识。 该设备还可以包括处理器和存储器。 存储器还可以包括两个伪噪声(PN)码,即第一PN码和第二PN码。 站点监视数据可以从站点监视系统接收。 可以使用第一PN码来传播站点监视数据,以提供第一扩散站监视数据。 可以使用第二PN码来扩展第一扩散站点监视数据,以提供第二扩散站点监视数据。 可以使用突发直接序列扩频无线电信号来发送第二扩展站点监视数据。

    Nanoemulsion vaccines
    7.
    发明授权
    Nanoemulsion vaccines 有权
    纳米乳剂疫苗

    公开(公告)号:US07314624B2

    公开(公告)日:2008-01-01

    申请号:US10162970

    申请日:2002-06-05

    IPC分类号: A61K39/12

    摘要: The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

    摘要翻译: 本发明提供了用于刺激免疫应答的方法和组合物。 具体地,本发明提供了使用纳米乳液化合物作为粘膜佐剂以诱导对环境病原体免疫的方法和组合物。 因此,在一些实施方案中,本发明提供了包含纳米乳剂和衍生自病原体的灭活病原体或蛋白质的纳米乳剂疫苗。 因此,本发明提供了针对各种环境和人释放的病原体的改进的疫苗。

    Implantable generating system
    8.
    发明授权
    Implantable generating system 失效
    植入式发电系统

    公开(公告)号:US07729767B2

    公开(公告)日:2010-06-01

    申请号:US11058403

    申请日:2005-02-15

    IPC分类号: A61N1/378

    CPC分类号: A61N1/3785

    摘要: An implantable generating system includes a generator assembly configured to be positioned within a living organism for converting mechanical motion into electrical energy. A linkage assembly is configured to be positioned within the living organism for mechanically coupling the generator assembly with one or more body parts displaceable during respiratory-based diaphragm motion.

    摘要翻译: 植入式发电系统包括发电机组件,其被配置为定位在活体内用于将机械运动转换为电能。 连杆组件被配置为定位在活体内,用于将发生器组件与在基于呼吸的隔膜运动期间可移位的一个或多个主体部件机械联接。