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39 条记录 (耗时 0.039 秒)

    Dendrimer conjugates
    2.
    发明授权
    Dendrimer conjugates 有权

    公开(公告)号：US08445528B2

    公开(公告)日：2013-05-21

    申请号：US13547929

    申请日：2012-07-12

    申请人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Dendrimer conjugates
    3.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08252834B2

    公开(公告)日：2012-08-28

    申请号：US12403179

    申请日：2009-03-12

    申请人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    Dendrimer conjugates
    4.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08889635B2

    公开(公告)日：2014-11-18

    申请号：US12570977

    申请日：2009-09-30

    申请人： James R. Baker, Jr. ,  Xue-min Cheng ,  Abraham F. L. Van Der Spek ,  Baohua Mark Huang ,  Thommey P. Thomas

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Abraham F. L. Van Der Spek ,  Baohua Mark Huang ,  Thommey P. Thomas

    IPC分类号： A61K31/5513 ,  A61K31/485 ,  A61K31/5377 ,  C07D489/02 ,  A61K47/48

    CPC分类号： A61K47/483 ,  A61K31/485 ,  A61K47/595

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    Pro-drug complexes and related methods of use
    5.
    发明授权
    Pro-drug complexes and related methods of use 有权
    前药复合物及相关使用方法

    公开(公告)号：US08853151B2

    公开(公告)日：2014-10-07

    申请号：US13378178

    申请日：2010-06-30

    申请人： James R. Baker, Jr. ,  Baohua M. Huang ,  Thommey P. Thomas

    发明人： James R. Baker, Jr. ,  Baohua M. Huang ,  Thommey P. Thomas

    IPC分类号： A61K31/4745 ,  A61K38/12 ,  C07D491/147 ,  C07K7/64 ,  A61K31/437 ,  A61K47/48

    CPC分类号： A61K31/437 ,  A61K47/64

    摘要： The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising one or more functional groups (e.g., imaging agents, targeting agents, and trigger agents) conjugated with a therapeutic agent (e.g., a chemotherapeutic agent), methods of synthesizing the same, as well as systems and methods utilizing the therapeutic and diagnostic compositions (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.))). Trigger agents include an indolequinone; attachment groups include a triazole ring; and therapeutic agents include camptothecin.

    摘要翻译： 本发明提供了使用包含与治疗剂缀合的一种或多种官能团（例如成像剂，靶向剂和触发剂）的前药复合物进行有效的位点特异性药物递送的方法，组合物和应用（例如， 化学治疗剂），其合成方法以及利用治疗和诊断组合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如， ，疾病（例如癌症）诊断和/或治疗等）））。 触发剂包括吲哚醌; 连接基团包括三唑环; 治疗剂包括喜树碱。

    Methods of preventing and treating microbial infections
    8.
    发明授权
    Methods of preventing and treating microbial infections 有权
    预防和治疗微生物感染的方法

    公开(公告)号：US06506803B1

    公开(公告)日：2003-01-14

    申请号：US09561111

    申请日：2000-04-28

    申请人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    发明人： James R. Baker, Jr. ,  Tarek Hamouda ,  Amy Shih ,  Andrzej Myc

    IPC分类号： A01N2500

    CPC分类号： A61K9/1075 ,  A61K45/06 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/938

    摘要： The present invention provides methods and compositions for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of microorganisms including bacteria, bacterial spores, fungi, fungal spores and enveloped viruses.

    摘要翻译： 本发明提供了使用水包油乳液灭活包括细菌孢子在内的细菌的方法和组合物。 水包油乳液包含油，表面活性剂和有机磷酸盐基溶剂。 这些方法可用于灭活多种微生物，包括细菌，细菌孢子，真菌，真菌孢子和包膜病毒。

    Multifunctional nanodevice platform
    9.
    发明授权
    Multifunctional nanodevice platform 失效
    多功能纳米设备平台

    公开(公告)号：US06471968B1

    公开(公告)日：2002-10-29

    申请号：US09570198

    申请日：2000-05-12

    申请人： James R. Baker, Jr. ,  Donald A. Tomalia

    发明人： James R. Baker, Jr. ,  Donald A. Tomalia

    IPC分类号： C07H2104

    CPC分类号： B82Y5/00 ,  A61K41/0057 ,  A61K41/0071 ,  A61K47/6949 ,  C08G83/003

    摘要： The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems generally comprise two or more separate components for targeting, imaging, sensing, and/or triggering release of a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

    摘要翻译： 本发明涉及新的治疗和诊断阵列。 更具体地，本发明涉及用于疾病诊断和治疗（例如癌症诊断和治疗）的基于树枝状大分子的多功能组合物和系统。 组合物和系统通常包含用于靶向，成像，感测和/或触发治疗或诊断材料释放并监测对细胞或组织（例如肿瘤）的治疗的反应的两个或更多个单独组分。