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公开(公告)号：US20050265901A1
公开(公告)日：2005-12-01
申请号：US10853901
申请日：2004-05-25
Applicant: James Sinclair , Brian Grot
Inventor： James Sinclair , Brian Grot
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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公开(公告)号：US20050048575A1
公开(公告)日：2005-03-03
申请号：US10837219
申请日：2004-04-30
Applicant: Peter Coassin , Todd Bennett , Brian Grot , David Nicol
Inventor： Peter Coassin , Todd Bennett , Brian Grot , David Nicol
IPC: B01L3/00 , B01L9/00 , C12M1/34 , G01N33/53 , G01N33/567
CPC classification number: B01L3/50851 , B01L9/523 , B01L2200/025 , B01L2200/142 , B01L2300/0829 , B01L2300/12
Abstract: A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.
Abstract translation: 用于储存和测定的双重用途的高密度板包括包括孔的矩阵的框架。 该基质优选包括3456个孔，顶部优选地与框架的平面大致齐平。 耐溶剂材料如环烯烃聚合物至少形成孔的底部，并且优选地，相同的耐溶剂材料形成框架，尽管通过变得不透明而从孔的底部变化。 蒸发控制孔优选包含在基质的周边，以减少边缘孔蒸发的影响。
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公开(公告)号：US08337754B2
公开(公告)日：2012-12-25
申请号：US12644839
申请日：2009-12-22
Applicant: Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
Inventor： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
IPC: G01N21/00
CPC classification number: G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
Abstract translation: 本文公开了用于开发免疫染色的生物样品的系统和方法。 本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。 可以使用自动注射器分注添加试剂。 试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。
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公开(公告)号：US20120201727A1
公开(公告)日：2012-08-09
申请号：US13450303
申请日：2012-04-18
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: B01L3/00
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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公开(公告)号：US08178055B2
公开(公告)日：2012-05-15
申请号：US12475381
申请日：2009-05-29
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: G01N21/75
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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Patent Agency Ranking
公开(公告)号：US20110151482A1
公开(公告)日：2011-06-23
申请号：US12644839
申请日：2009-12-22
Applicant: Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
Inventor： Michael P. Emery , Matthew C. Wallace , James E. Sinclair , Raymond J. Gonzales , Brian Grot , Sanjay S. Magavi
CPC classification number: G01N1/31 , B01L3/0217 , B01L2200/147 , B01L2200/16 , B01L2300/1822 , B01L2400/0487 , G01N1/30 , G01N27/44721 , G01N33/54366 , G01N35/00029 , G01N35/10 , G01N2035/00425 , Y10T436/2575
Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
Abstract translation: 本文公开了用于开发免疫染色的生物样品的系统和方法。 本文公开的系统是自动化的并且被配置为控制开发过程的一个或多个步骤。 可以使用自动注射器分注添加试剂。 试剂温度，试剂搅拌和洗涤程序是可编程的，可以单独控制，同时进行单独的免疫染色程序。
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7.发明申请Automated laboratory for high-throughput biological assays and RNA interference 有权用于高通量生物测定和RNA干扰的自动化实验室公开(公告)号：US20050054083A1
公开(公告)日：2005-03-10
申请号：US10837218
申请日：2004-04-30
Applicant: Minh Vuong , Todd Bennett , Javier Flores , Brian Grot , Daniel Hale , Huy Nguyen , Walter Niles , Tuong Phan , Steve Rodems , Jeff Stack , Peter Coassin
Inventor： Minh Vuong , Todd Bennett , Javier Flores , Brian Grot , Daniel Hale , Huy Nguyen , Walter Niles , Tuong Phan , Steve Rodems , Jeff Stack , Peter Coassin
IPC: B23B27/04 , C12M1/34 , C12N20060101
CPC classification number: G01N35/1074 , G01N35/028
Abstract: The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.
Abstract translation: 本发明是一种自动多功能综合实验室系统，包括用于构建和测量生物测定的可互换模块化元件。 模块化元件的功能可以包括多井平台处理，化学试剂或细胞管理，用于测定构建的液体的体积转移或用于回收用于分析的反应产物，在受控环境条件下孵育，来自测定的光谱信号的测量，处理 并对所得光谱数据进行分析等功能。 模块化元件围绕若干机器人元件布置，其将板递送到不同的模块元件，将板传递到由不同的机器人元件服务的模块组或板处理中所需的其他动作。 液体转移至多孔平台，用于测定结构或细胞中生理事件发生所必需的多孔平台，在专门用于转移纳升或更小体积量的化学浓缩物或微量的测定试剂，细胞，培养基和 其他检测成分。 本发明的应用包括细胞中多个基因的表达的定量和分析，多基因表达动力学的测定，多重信号转导途径的激活或抑制分析，筛选化合物对多基因表达的调节作用或 信号转导途径或细胞的其他生物化学网络或其他分析生物或生物化学测定。
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公开(公告)号：US07858044B2
公开(公告)日：2010-12-28
申请号：US10837219
申请日：2004-04-30
Applicant: Peter J. Coassin , Todd Bennett , Brian Grot , David Nicol
Inventor： Peter J. Coassin , Todd Bennett , Brian Grot , David Nicol
IPC: B01L3/00
CPC classification number: B01L3/50851 , B01L9/523 , B01L2200/025 , B01L2200/142 , B01L2300/0829 , B01L2300/12
Abstract: A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.
Abstract translation: 用于储存和测定的双重用途的高密度板包括包括孔的矩阵的框架。 该基质优选包括3456个孔，顶部优选地与框架的平面大致齐平。 耐溶剂材料如环烯烃聚合物至少形成孔的底部，并且优选地，相同的耐溶剂材料形成框架，尽管通过变得不透明而从孔的底部变化。 蒸发控制孔优选包含在基质的周边，以减少边缘孔蒸发的影响。
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公开(公告)号：US20090238727A1
公开(公告)日：2009-09-24
申请号：US12475381
申请日：2009-05-29
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
Abstract translation: 这里公开了一种模块化试管架。 机架包含多个可以耦合在一起以形成试管架的子机架。 子机架可以设计成适合各种科学仪器，包括固定式转子离心机。 组装的试管架可以是允许使用标准阵列移液器的格式和尺寸。 因此，提供允许使用标准阵列移液器和高g离心的系统。
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公开(公告)号：US08398941B2
公开(公告)日：2013-03-19
申请号：US13450303
申请日：2012-04-18
Applicant: James E. Sinclair , Brian Grot
Inventor： James E. Sinclair , Brian Grot
IPC: B01L3/00
CPC classification number: B01L9/06 , B01L3/50855 , Y10S436/809 , Y10T436/111666
Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.
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