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    Valve prosthesis
    4.
    发明授权
    Valve prosthesis 有权
    瓣膜假体

    公开(公告)号：US09289291B2

    公开(公告)日：2016-03-22

    申请号：US13505885

    申请日：2010-11-05

    申请人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Matthew J. Gillespie

    发明人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Matthew J. Gillespie

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2436 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2230/0058 ,  A61F2230/0078 ,  A61F2250/003 ,  A61F2250/0039 ,  A61F2250/0069

    摘要： The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

    摘要翻译： 本公开涉及可替换为用于基于导管的部署到植入部位的瓣膜置换装置，以及用于递送瓣膜假体的系统，包括具有所公开的瓣膜置换装置的特殊特征的假体。 这些装置包括用于安全和持久精密植入的高效粘附机构。 附着机构可以采用独特的密封机构，其包括缓慢扩张的袖带，由此装置未固定就位直到完成植入程序。 植入的装置，可选地与袖带一起防止了周围的泄漏并且并入适当的小叶系统以便在原位可靠地起作用。

    IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION
    5.
    发明申请
    IN VIVO MEASUREMENT OF MITOCHONDRIAL FUNCTION 有权
    人体功能测量

    公开(公告)号：US20110288418A1

    公开(公告)日：2011-11-24

    申请号：US12935755

    申请日：2009-04-01

    申请人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Mahsa Ranji

    发明人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Mahsa Ranji

    IPC分类号： A61B6/00

    CPC分类号： A61B5/413 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.

    摘要翻译： 本文公开了用于评估活体受试者的线粒体功能的装置，其包括导管，其包括限定内腔，远端和近端的护套，所述护套包括用于将光照射到受试者内的靶上的光导，并用于接收来自 目标; 光源，其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。 还公开了评估活体受试者线粒体功能的方法，包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。

    VALVE PROSTHESIS
    6.
    发明申请
    VALVE PROSTHESIS 有权
    阀门优先

    公开(公告)号：US20120303116A1

    公开(公告)日：2012-11-29

    申请号：US13505885

    申请日：2010-11-05

    申请人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Matthew J. Gillespie

    发明人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Matthew J. Gillespie

    IPC分类号： A61F2/24 ,  A61F2/84

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2436 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0061 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2230/0058 ,  A61F2230/0078 ,  A61F2250/003 ,  A61F2250/0039 ,  A61F2250/0069

    摘要： The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

    摘要翻译： 本公开涉及可替换为用于基于导管的部署到植入部位的瓣膜置换装置，以及用于递送瓣膜假体的系统，包括具有所公开的瓣膜置换装置的特殊特征的假体。 这些装置包括用于安全和持久精密植入的高效粘附机构。 附着机构可以采用独特的密封机构，其包括缓慢扩张的袖带，由此装置未固定就位直到完成植入程序。 植入的装置，可选地与袖带一起防止了周围的泄漏并且并入适当的小叶系统以便在原位可靠地起作用。

    AUTOMATIC QUANTIFICATION OF MITRAL VALVE DYNAMICS WITH REAL-TIME 3D ULTRASOUND
    8.
    发明申请
    AUTOMATIC QUANTIFICATION OF MITRAL VALVE DYNAMICS WITH REAL-TIME 3D ULTRASOUND 有权
    用实时三维超声波自动定量麻醉动力学

    公开(公告)号：US20130195335A1

    公开(公告)日：2013-08-01

    申请号：US13580833

    申请日：2011-02-25

    申请人： Robert C. Gorman ,  Alison Pouch ,  Joseph H. Gorman, III ,  Chandra Sehgal ,  Paul A. Yushkevich ,  Benjamin Jackson

    发明人： Robert C. Gorman ,  Alison Pouch ,  Joseph H. Gorman, III ,  Chandra Sehgal ,  Paul A. Yushkevich ,  Benjamin Jackson

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G06T7/12 ,  G06T7/174 ,  G06T2207/10076 ,  G06T2207/20128 ,  G06T2207/30048

    摘要： A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.

    摘要翻译： 定量分析二尖瓣的一系列rt-3DE图像，以便例如预测复发性缺血性二尖瓣反流程度（IMR）的程度，并综合评估整个二尖瓣的小叶束缚和“起搏”。 根据该方法，首先，rt-3DE图像以对称不同形态记录，以获得关于二尖瓣随时间变化的信息。 其次，在心脏周期的每个时间点，二尖瓣与水平集或其他已知的分割方法分段，最小的用户交互作用。 第三，关于二尖瓣结构的信息被简化为3D中间模型，形状的紧凑表示。 换句话说，二尖瓣的体积分割被冷凝成适合临床相关形态测定的形式。

    In vivo measurement of mitochondrial function
    9.
    发明授权
    In vivo measurement of mitochondrial function 有权
    体内线粒体功能测定

    公开(公告)号：US08473036B2

    公开(公告)日：2013-06-25

    申请号：US12935755

    申请日：2009-04-01

    申请人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Mahsa Ranji

    发明人： Joseph H. Gorman, III ,  Robert C. Gorman ,  Mahsa Ranji

    IPC分类号： A61B6/00

    CPC分类号： A61B5/413 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.

    摘要翻译： 本文公开了用于评估活体受试者的线粒体功能的装置，其包括导管，其包括限定内腔，远端和近端的护套，所述护套包括用于将光照射到受试者内的靶上的光导，并用于接收来自 目标; 光源，其中所述导管适于将光从所述光源传输到所述光导; 以及用于从光导接收荧光信号并将荧光信号与靶的线粒体功能相关联的检测器。 还公开了评估活体受试者线粒体功能的方法，包括将导管放置在受试者内的感兴趣位点附近; 使用导管从感兴趣的位点的细胞获得荧光信号; 并将荧光信号与细胞的线粒体功能相关联。

    Automatic quantification of mitral valve dynamics with real-time 3D ultrasound
    10.
    发明授权
    Automatic quantification of mitral valve dynamics with real-time 3D ultrasound 有权
    用实时三维超声自动量化二尖瓣动态

    公开(公告)号：US09129392B2

    公开(公告)日：2015-09-08

    申请号：US13580833

    申请日：2011-02-25

    申请人： Robert C. Gorman ,  Alison Pouch ,  Joseph H. Gorman, III ,  Chandra Sehgal ,  Paul A. Yushkevich ,  Benjamin Jackson

    发明人： Robert C. Gorman ,  Alison Pouch ,  Joseph H. Gorman, III ,  Chandra Sehgal ,  Paul A. Yushkevich ,  Benjamin Jackson

    IPC分类号： G06K9/00 ,  G06T7/00

    CPC分类号： G06T7/0012 ,  G06T7/12 ,  G06T7/174 ,  G06T2207/10076 ,  G06T2207/20128 ,  G06T2207/30048

    摘要： A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.

    摘要翻译： 定量分析二尖瓣的一系列rt-3DE图像，以便例如预测复发性缺血性二尖瓣反流程度（IMR）的程度，并综合评估整个二尖瓣的小叶束缚和“起搏”。 根据该方法，首先，rt-3DE图像以对称不同形态记录，以获得关于二尖瓣随时间变化的信息。 其次，在心脏周期的每个时间点，二尖瓣与水平集或其他已知的分割方法分段，最小的用户交互作用。 第三，关于二尖瓣结构的信息被简化为3D中间模型，形状的紧凑表示。 换句话说，二尖瓣的体积分割被冷凝成适合临床相关形态测定的形式。