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公开(公告)号：US09694081B2
公开(公告)日：2017-07-04
申请号：US13805501
申请日：2011-06-17
摘要： The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
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公开(公告)号：US20140148395A1
公开(公告)日：2014-05-29
申请号：US13805501
申请日：2011-06-17
摘要： The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
摘要翻译： 本发明涉及包含（i）生物相容性水凝胶和（ii）包含在所述水凝胶内的一种或多种治疗剂的组合物; 其中所述水凝胶使用包含能够被酶降解的肽序列的交联剂进行交联; 治疗剂作为与酶的存在相关的病症的治疗是有效的。
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3.发明申请MICROSPHERE/NANOFIBER COMPOSITES FOR DELIVERY OF DRUGS, GROWTH FACTORS, AND OTHER AGENTS 审中-公开用于输送药物，生长因子和其他药剂的MICROSPHERE / NANOFIBER复合材料公开(公告)号：US20120093717A1
公开(公告)日：2012-04-19
申请号：US13148965
申请日：2010-01-29
申请人： Robert Mauck , Lara Ionescu , Jason Alan Burdick , Brendon Baker
发明人： Robert Mauck , Lara Ionescu , Jason Alan Burdick , Brendon Baker
CPC分类号： A61L27/18 , A61L27/22 , A61L27/24 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2300/44 , A61L2300/442 , A61L2300/45 , A61L2300/604 , A61L2300/622 , A61L2400/12 , C08L67/04 , C08L89/00
摘要： Provided are compositions that include polymeric fibers and microspheres entrapped within the fibers, the compositions being capable of controlled delivery of one or more agents while also maintaining their structural properties. Also provided are related methods of fabricating these compositions and methods of utilizing the compositions to deliver agents to a subject.
摘要翻译： 提供的是包含聚合物纤维和包含在纤维内的微球的组合物，该组合物能够控制递送一种或多种试剂，同时还保持其结构性质。 还提供了制造这些组合物的相关方法和利用组合物将药物递送至受试者的方法。
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4.发明申请Aligned Fibrous Materials With Spatially Varying Fiber Orientation and Related Methods 审中-公开具有空间变化的光纤取向和相关方法的对准纤维材料公开(公告)号：US20120265300A1
公开(公告)日：2012-10-18
申请号：US13422027
申请日：2012-03-16
申请人： Robert L. Mauck , Matthew B. Fisher , Brendon M. Baker , Amy M. Silverstein , Jason Alan Burdick
发明人： Robert L. Mauck , Matthew B. Fisher , Brendon M. Baker , Amy M. Silverstein , Jason Alan Burdick
IPC分类号： B32B5/16 , B32B27/02 , D02G3/22 , A61K35/00 , B32B37/14 , B29C47/00 , A61K9/00 , B32B5/12 , A61F2/38
CPC分类号： A61F2/3872 , A61F2/3094 , A61F2/30965 , B29C48/05 , B32B5/12 , B32B5/26 , B32B37/182 , B32B2250/02 , B32B2305/28 , B32B2310/0843 , B32B2535/00 , B82Y30/00 , D01D5/003 , D01F1/10 , Y10T428/24124 , Y10T428/24132 , Y10T428/25 , Y10T428/268 , Y10T428/31504
摘要： Provided are materials comprising layers of anisotropically aligned fibers, the alignment of which fibers may be adjusted so as to give rise to circumferentially-aligned fibers that replicate the fiber alignment of native fibrous tissue, such as the meniscus or the annulus fibrosis. Also provided are laminates formed from the disclosed materials, as well as methods of fabricating the disclosed materials and laminates.
摘要翻译： 提供的是包含各向异性取向纤维层的材料，可以调整纤维的对准，以便产生复制天然纤维组织（例如弯液面或环状纤维化）的纤维排列的周向排列的纤维。 还提供了由所公开的材料形成的层压体，以及制造所公开的材料和层压材料的方法。
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公开(公告)号：US20120114615A1
公开(公告)日：2012-05-10
申请号：US13139537
申请日：2009-12-08
申请人： Jason Alan Burdick , Sujata Sahoo , Cindy Chung
发明人： Jason Alan Burdick , Sujata Sahoo , Cindy Chung
CPC分类号： A61K47/36 , A61L27/18 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/442 , A61L2300/604 , A61L2430/06 , C12N5/0012 , C12N5/0663 , C12N2533/40 , C12N2533/80 , C08L67/04
摘要： Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used.
摘要翻译： 提供能够可控制的水解降解并适合治疗剂的控制释放的多糖组合物。 还提供了合成这种组合物的方法和可以使用组合物的各种应用。
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公开(公告)号：US11090387B2
公开(公告)日：2021-08-17
申请号：US13139537
申请日：2009-12-08
申请人： Jason Alan Burdick , Sujata Sahoo , Cindy Chung
发明人： Jason Alan Burdick , Sujata Sahoo , Cindy Chung
IPC分类号： A61K35/12 , A61K47/36 , A61K38/19 , C08B37/08 , C08B37/00 , A61K47/34 , A61L27/58 , A61L27/52 , A61L27/18 , A61L27/38 , A61L27/54 , C12N5/0775 , C12N5/00
摘要： Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compositions and a variety of applications in which the compositions may be used.
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公开(公告)号：US08808681B2
公开(公告)日：2014-08-19
申请号：US11758078
申请日：2007-06-05
IPC分类号： A61K47/32 , A61K35/00 , C08F2/48 , C08G73/00 , C08F299/04 , C08F290/06 , C08F283/00 , C08G73/02 , C08F299/02 , C08L79/02 , C08G63/685
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译： 丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。 这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。 因此，可以调整材料的性质以达到期望的用途。 制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。
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公开(公告)号：US20080145338A1
公开(公告)日：2008-06-19
申请号：US11758078
申请日：2007-06-05
CPC分类号： C08L79/02 , C08F283/00 , C08F290/06 , C08F290/061 , C08F290/065 , C08F299/024 , C08F299/0485 , C08G63/6858 , C08G73/02
摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
摘要翻译： 丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。 这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。 因此，可以调整材料的性质以达到期望的用途。 制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。
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