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    NEUROLOGICAL MONITORING AND ALERTS
    2.
    发明申请
    NEUROLOGICAL MONITORING AND ALERTS 有权
    神经监测和警报

    公开(公告)号：US20110201944A1

    公开(公告)日：2011-08-18

    申请号：US13026961

    申请日：2011-02-14

    申请人： Jason A. Higgins ,  Michael Bland ,  Kent W. Leyde ,  W. Douglas Sheffield ,  John F. Harris ,  David M. Himes

    发明人： Jason A. Higgins ,  Michael Bland ,  Kent W. Leyde ,  W. Douglas Sheffield ,  John F. Harris ,  David M. Himes

    IPC分类号： A61B5/0205 ,  A61B5/0476 ,  A61N1/36

    CPC分类号： A61N1/37258 ,  A61B5/4094 ,  A61N1/00 ,  A61N1/0529 ,  G16H40/67

    摘要： A system for providing alerts of neurological events occurring in a human subject is provided. The system includes: a monitoring module adapted to detect and sample a neurological signal; an event detection module coupled to the monitoring module for detecting one or more types of predetermined reportable events based on the detected neurological signal; and an alert module coupled to the event detection module, wherein upon the detection of a reportable event by the event detection module, said alert module selects a first alert contact from a plurality of contacts contained in a contact list, and generates a first alert communication to the first alert contact.

    摘要翻译： 提供了一种用于提供在人类受试者中发生的神经系统事件的警报的系统。 该系统包括：适于检测和采样神经信号的监测模块; 事件检测模块，耦合到监视模块，用于基于检测到的神经信号检测一种或多种类型的预定可报告事件; 以及耦合到所述事件检测模块的警报模块，其中当所述事件检测模块检测到可报告事件时，所述警报模块从包含在联系人列表中的多个联系人中选择第一警报联系人，并且生成第一警报通信 到第一个警报联系人。

    Patient Advisory Device
    3.
    发明申请
    Patient Advisory Device 有权
    患者咨询设备

    公开(公告)号：US20090062682A1

    公开(公告)日：2009-03-05

    申请号：US12180996

    申请日：2008-07-28

    申请人： Michael Bland ,  Kent W. Leyde ,  Neil G. McIlvaine ,  Shan Gaw ,  Peter Weiss ,  John F. Harris

    发明人： Michael Bland ,  Kent W. Leyde ,  Neil G. McIlvaine ,  Shan Gaw ,  Peter Weiss ,  John F. Harris

    IPC分类号： A61B5/0476

    CPC分类号： A61B5/0476 ,  A61B5/0031 ,  A61B5/4094

    摘要： A patient advisory device (“PAD”) and its methods of use. The PAD may be configured to alert the patient about an estimated brain state of the patient. In preferred embodiments, the PAD is adapted to alert the patient of the patient's brain state, which corresponds to the patient's propensity of transitioning into an ictal brain state, e.g., having a seizure. Based on the specific type of alert, the patient will be made aware whether they are highly unlikely to have a seizure for a given period of time, an elevated propensity of having a seizure, a seizure is occurring or imminent, or the patient's brain state is unknown.

    摘要翻译： 患者咨询器（“PAD”）及其使用方法。 PAD可以被配置为警告患者关于患者的估计的脑状态。 在优选实施例中，PAD适于警告患者患者的脑状态，其对应于患者转变为脑血管状态的倾向，例如具有癫痫发作。 根据具体的警戒类型，患者将会意识到他们是否不太可能在给定的时间内癫痫发作，癫痫发作，癫痫发作或迫在眉睫的倾向，或患者的大脑状态 是未知数

    Multi-Channel Amplifier Techniques
    5.
    发明申请
    Multi-Channel Amplifier Techniques 审中-公开
    多通道放大器技术

    公开(公告)号：US20120257339A1

    公开(公告)日：2012-10-11

    申请号：US13441609

    申请日：2012-04-06

    申请人： Kent W. Leyde ,  Tyler R. Hart ,  Khaled M. Boulos ,  Jason A. Higgins

    发明人： Kent W. Leyde ,  Tyler R. Hart ,  Khaled M. Boulos ,  Jason A. Higgins

    IPC分类号： H05K7/00 ,  H03F3/45 ,  H03F3/68

    CPC分类号： H03F3/45475 ,  H03F2200/261 ,  H03F2203/45528 ,  H03F2203/45594 ,  H03F2203/45631

    摘要： Techniques for amplifying a plurality of input voltages to generate a corresponding plurality of output voltages. In an exemplary embodiment, each of the plurality of input voltages is referenced to a common voltage comprising the average of the plurality of input voltages, without the need to reference an independently provided common voltage. In an alternative exemplary embodiment, techniques are provided for automatically measuring the input impedance between any two nodes corresponding to the plurality of input voltages. Further techniques are provided for coupling input nodes of the amplifier modules to a common reference voltage, and to the housing of the apparatus.

    摘要翻译： 用于放大多个输入电压以产生相应的多个输出电压的技术。 在示例性实施例中，多个输入电压中的每一个参考包括多个输入电压的平均值的公共电压，而不需要参考独立提供的公共电压。 在替代示例性实施例中，提供了用于自动测量对应于多个输入电压的任何两个节点之间的输入阻抗的技术。 提供了用于将放大器模块的输入节点耦合到公共参考电压的另外的技术，并且耦合到设备的外壳。

    Communication Error Alerting in an Epilepsy Monitoring System
    6.
    发明申请
    Communication Error Alerting in an Epilepsy Monitoring System 有权
    癫痫监测系统通信错误警报

    公开(公告)号：US20110213222A1

    公开(公告)日：2011-09-01

    申请号：US13070333

    申请日：2011-03-23

    申请人： Kent W. Leyde ,  John F. Harris

    发明人： Kent W. Leyde ,  John F. Harris

    IPC分类号： A61B5/00 ,  A61B5/04

    CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/4094 ,  A61B2560/0271 ,  A61M5/14276 ,  A61N1/36082 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/37282 ,  G06F19/3418

    摘要： Systems and methods for monitoring neurological signals in a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable communication device external to the patient's body, said communication device configured to wirelessly communicate with the implantable assembly and to transmit a communication error alert to a caregiver advisory device in the event of a communication error between the implantable assembly and the communication device.

    摘要翻译： 提供了用于监测患者神经信号的系统和方法。 该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及在患者身体外部的可充电通信设备，所述通信设备被配置为与可植入组件进行无线通信，并且在可植入组件和通信设备之间发生通信错误的情况下向通知设备发送通信错误警报。

    Patient Entry Recording in an Epilepsy Monitoring System
    7.
    发明申请
    Patient Entry Recording in an Epilepsy Monitoring System 审中-公开
    癫痫监测系统中的患者进入记录

    公开(公告)号：US20110172554A1

    公开(公告)日：2011-07-14

    申请号：US13070357

    申请日：2011-03-23

    申请人： Kent W. Leyde ,  John F. Harris

    发明人： Kent W. Leyde ,  John F. Harris

    IPC分类号： A61B5/048

    CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/4094 ,  A61B2560/0271 ,  A61M5/14276 ,  A61N1/36082 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/37282 ,  G06F19/3418

    摘要： Systems and methods for monitoring a patient are provided. The system includes: an implantable sensor adapted to collect neurological signals; an implantable assembly configured to sample the neurological signals collected by the sensor; and a rechargeable external assembly configured to wirelessly receive the sampled neurological signals from the implantable assembly, said external assembly being further configured to record a patient entry in response to receiving an input from the patient. The method includes: collecting neurological signals with a sensor implanted in the patient; sampling the neurological signals collected by the sensor with an implantable assembly implanted in the patient; and transmitting the sampled neurological signals from the implantable assembly to a rechargeable external assembly external to the patient; and recording a patient entry in response to receiving an input from the patient.

    摘要翻译： 提供了用于监测患者的系统和方法。 该系统包括：适于收集神经信号的可植入传感器; 植入式组件，被配置为对由所述传感器收集的神经信号进行采样; 以及可充电外部组件，其被配置为从所述可植入组件无线地接收所述取样的神经信号，所述外部组件还被配置为响应于接收到来自所述患者的输入而记录患者入口。 该方法包括：用植入患者的传感器收集神经信号; 用植入患者的可植入组件对由传感器收集的神经信号进行采样; 以及将所述取样的神经信号从所述可植入组件传输到患者外部的可再充电外部组件; 以及响应于从患者接收到输入而记录患者入口。

    Methods and Systems for Measuring a Subject's Susceptibility to a Seizure
    8.
    发明申请
    Methods and Systems for Measuring a Subject's Susceptibility to a Seizure 审中-公开
    测量受试者对癫痫发作敏感性的方法和系统

    公开(公告)号：US20080183097A1

    公开(公告)日：2008-07-31

    申请号：US12020507

    申请日：2008-01-25

    申请人： Kent W. Leyde ,  John F. Harris

    发明人： Kent W. Leyde ,  John F. Harris

    IPC分类号： A61B5/0476

    CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/4094 ,  A61B2560/0271 ,  A61M5/14276 ,  A61N1/36082 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/37282 ,  G06F19/3418

    摘要： Systems and methods for monitoring physiological signals from a subject to determine the subject's susceptibility for having a seizure. Also includes are systems and methods for activating an alert when there is a communication error between an implanted device and the external assembly. Additionally included are systems and method for long-term substantially continuous physiological signal data collection. At least a portion of the systems of the present invention may be implanted within the subject. In some embodiments, brain activity signals are sampled from the subject with implanted electrodes and are communicated to an external assembly where the brain activity signals are analyzed to determine the subject's susceptibility for having a seizure.

    摘要翻译： 用于监测来自受试者的生理信号的系统和方法，以确定受试者具有癫痫发作的易感性。 还包括当在植入装置和外部组件之间存在通信错误时激活警报的系统和方法。 另外包括用于长期基本上连续的生理信号数据收集的系统和方法。 本发明的系统的至少一部分可以植入对象内。 在一些实施例中，从植入电极的受试者采集脑活动信号，并将其传达到外部组件，其中分析脑活动信号以确定受试者对于发作的易感性。

    Implantable systems and methods for identifying a contra-ictal condition in a subject
    10.
    发明授权
    Implantable systems and methods for identifying a contra-ictal condition in a subject 有权
    用于识别受试者的反面条件的植入式系统和方法

    公开(公告)号：US08036736B2

    公开(公告)日：2011-10-11

    申请号：US12053312

    申请日：2008-03-21

    申请人： David Snyder ,  Kent W. Leyde ,  John F. Harris

    发明人： David Snyder ,  Kent W. Leyde ,  John F. Harris

    IPC分类号： A61B5/04

    CPC分类号： A61B5/02055 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0452 ,  A61B5/048 ,  A61B5/08 ,  A61B5/145 ,  A61B5/14552 ,  A61B5/4094 ,  A61B5/7232 ,  A61B2560/0219

    摘要： Systems and methods of monitoring a subject's neurological condition are provided. In some embodiments, the method includes the steps of analyzing a physiological signal (such as an EEG) from a subject to determine if the subject is in a contra-ictal condition; and if the subject is in a contra-ictal condition, providing an indication (e.g., to the subject and/or to a caregiver) that the subject is in the contra-ictal condition. The systems and methods may utilize a minimally invasive, leadless device to monitor the subject's condition. In some embodiments, if the subject is in a pro-ictal condition, the method includes the step of providing an indication (such as a red light) that the subject is in the pro-ictal condition.

    摘要翻译： 提供了监测受试者神经系统状况的系统和方法。 在一些实施例中，该方法包括分析来自受试者的生理信号（例如EEG）以确定受试者是否处于对立状态的步骤; 并且如果受试者处于对立状态，则向对象提供指示（例如，对受试者和/或照顾者）对象处于对立状态。 系统和方法可以利用微创无引导装置来监测受检者的状况。 在一些实施例中，如果受试者处于预备状态，则该方法包括提供受试者处于预防状态的指示（例如红光）的步骤。