MICROARRAY CHIP AND METHOD FOR DETECTION OF CHROMOSOMAL ABNORMALITY
    1.
    发明申请
    MICROARRAY CHIP AND METHOD FOR DETECTION OF CHROMOSOMAL ABNORMALITY 审中-公开
    微波芯片和检测染色体异常的方法

    公开(公告)号:US20100210469A1

    公开(公告)日:2010-08-19

    申请号:US12440397

    申请日:2007-09-07

    IPC分类号: C40B30/00 C40B40/06 C40B50/14

    摘要: The present invention relates to techniques to detect chromosomal columns abnormalities. More specifically, the present invention is directed to a microarray chip for detecting chromosomal abnormalities comprising one or more pooled probe sets, wherein the pooled probe set is specific to a chromosomal abnormality and all probes of each pooled probe set are immobilized together in at least one spot; a method of detecting chromosomal abnormalities using the microarray chip; a kit for diagnosing diseases associated with chromosomal abnormalities comprising the microarray chip; and a method of diagnosing a disease associated with a chromosomal abnormality by identifying the chromosomal abnormality specific to the disease using the microarray chip. The present invention relates to techniques to detect chromosomal abnormalities. More specifically, the present invention is directed to a microarray chip for detecting chromosomal abnormalities comprising one or more pooled probe sets, wherein the pooled probe set is specific to a chromosomal abnormality and all probes of each pooled probe set are immobilized together in at least one spot; a method of detecting chromosomal abnormalities using the microarray chip; a kit for diagnosing diseases associated with chromosomal abnormalities comprising the microarray chip; and a method of diagnosing a disease associated with a chromosomal abnormality by identifying the chromosomal abnormality specific to the disease using the microarray chip.

    摘要翻译: 本发明涉及检测染色体柱异常的技术。 更具体地,本发明涉及一种用于检测染色体异常的微阵列芯片,其包含一个或多个汇集的探针组,其中所述合并的探针组对于染色体异常是特异性的,并且每个合并的探针组的所有探针在至少一个 点; 使用微阵列芯片检测染色体异常的方法; 用于诊断与包含微阵列芯片的染色体异常相关疾病的试剂盒; 以及通过使用微阵列芯片鉴定对疾病特异性的染色体异常来诊断与染色体异常相关的疾病的方法。 本发明涉及检测染色体异常的技术。 更具体地,本发明涉及一种用于检测染色体异常的微阵列芯片,其包含一个或多个汇集的探针组,其中所述合并的探针组对于染色体异常是特异性的,并且每个合并的探针组的所有探针在至少一个 点; 使用微阵列芯片检测染色体异常的方法; 用于诊断与包含微阵列芯片的染色体异常相关疾病的试剂盒; 以及通过使用微阵列芯片鉴定对疾病特异性的染色体异常来诊断与染色体异常相关的疾病的方法。

    TRANSFORMANT FOR PRODUCTION OF LACTIC ACID OF HIGH OPTICAL PURITY AND METHOD FOR PRODUCING LACTIC ACID USING THE SAME
    3.
    发明申请
    TRANSFORMANT FOR PRODUCTION OF LACTIC ACID OF HIGH OPTICAL PURITY AND METHOD FOR PRODUCING LACTIC ACID USING THE SAME 有权
    用于生产高光泽度的酸的转化剂及使用其生产酸乳酸的方法

    公开(公告)号:US20140128635A1

    公开(公告)日:2014-05-08

    申请号:US14001123

    申请日:2011-02-23

    IPC分类号: C12P7/56 C07C59/08

    摘要: Disclosed is the biological production of lactic acid using a microorganism. A transformant capable of producing lactic acid of high optical purity at high yield, a method for the preparation thereof, and a method for producing lactic acid in a convenient and economically beneficial manner using the same are provided. The Zymomonas mobilis transformant can produce lactic acid of high optical purity at high yield without a stringent limitation to production conditions and a regulation of the intracellular metabolism pathway. Because it requires no additional separation and purification steps, the use of the transformant allows the production of lactic acid in a short process, resulting in a significant reduction in production cost, and avoiding the environment problems caused by precipitate wastes, which brings about environmental issues.

    摘要翻译: 公开了使用微生物的乳酸的生物生产。 提供能够以高收率生产高光学纯度的乳酸的转化体,其制备方法,以及使用该乳酸的方便且经济有益的方法生产乳酸的方法。 运动发酵单胞菌转化体可以以高产率生产高光学纯度的乳酸,而不会严格限制生产条件和细胞内代谢途径的调节。 因为不需要额外的分离和纯化步骤,因此转化体的使用允许在短时间内生产乳酸,导致生产成本显着降低,并避免沉淀废物引起的环境问题,从而带来环境问题 。

    Transformant for production of lactic acid of high optical purity and method for producing lactic acid using the same
    4.
    发明授权
    Transformant for production of lactic acid of high optical purity and method for producing lactic acid using the same 有权
    用于生产高光学纯度的乳酸的转化体和使用其制备乳酸的方法

    公开(公告)号:US09428775B2

    公开(公告)日:2016-08-30

    申请号:US14001123

    申请日:2011-02-23

    摘要: Disclosed is the biological production of lactic acid using a microorganism. A transformant capable of producing lactic acid of high optical purity at high yield, a method for the preparation thereof, and a method for producing lactic acid in a convenient and economically beneficial manner using the same are provided. The Zymomonas mobilis transformant can produce lactic acid of high optical purity at high yield without a stringent limitation to production conditions and a regulation of the intracellular metabolism pathway. Because it requires no additional separation and purification steps, the use of the transformant allows the production of lactic acid in a short process, resulting in a significant reduction in production cost, and avoiding the environment problems caused by precipitate wastes, which brings about environmental issues.

    摘要翻译: 公开了使用微生物的乳酸的生物生产。 提供能够以高收率生产高光学纯度的乳酸的转化体,其制备方法,以及使用该乳酸的方便且经济有益的方法生产乳酸的方法。 运动发酵单胞菌转化体可以以高产率生产高光学纯度的乳酸,而不会严格限制生产条件和细胞内代谢途径的调节。 因为不需要额外的分离和纯化步骤,因此转化体的使用允许在短时间内生产乳酸,导致生产成本的显着降低,并避免沉淀废物引起的环境问题,从而产生环境问题 。