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公开(公告)号：US07495231B2
公开(公告)日：2009-02-24
申请号：US11223285
申请日：2005-09-08
CPC分类号： H01J49/0418 , G03B15/07
摘要： The invention provides an apparatus for producing an image of a global surface of an ion source sample plate that is exterior to an ion source. In general terms, the apparatus contains a sample plate for an ion source, an imaging device (e.g., a CCD or CMOS camera) and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate surface. The apparatus may be present at a location that is remote to the ion source.
摘要翻译： 本发明提供了一种用于产生离子源外部的离子源样品板的全局表面的图像的装置。 通常，该装置包含用于离子源的样品板，成像装置（例如，CCD或CMOS照相机）和照明装置，其被配置为产生接触样品板表面以限定掠入角的光束 在光束和样品板表面之间。 该装置可以存在于远离离子源的位置处。
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公开(公告)号：US07435951B2
公开(公告)日：2008-10-14
申请号：US11148786
申请日：2005-06-08
CPC分类号： H01J49/0418 , G03B15/07 , H01J49/0004
摘要： The invention provides a mass spectrometry system ion source containing a sample plate and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate surface. The ion source may also contain an imaging device, e.g., a CCD or CMOS camera or the like, for viewing the area. In one embodiment, the imaging device may be connected to a display, e.g., a video monitor. Methods and mass spectrometry systems empliying the ion source are also provided.
摘要翻译： 本发明提供一种包含样品板和照明装置的质谱系统离子源，其被配置为产生与样品板表面接触以限定光束和样品板表面之间的掠射角的光束。 离子源还可以包含用于观察该区域的成像装置，例如CCD或CMOS照相机等。 在一个实施例中，成像装置可以连接到显示器，例如视频监视器。 还提供了使用离子源的方法和质谱系统。
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公开(公告)号：US20080226133A1
公开(公告)日：2008-09-18
申请号：US11686200
申请日：2007-03-14
申请人： Jean-Luc Truche , Gregor T. Overney
发明人： Jean-Luc Truche , Gregor T. Overney
IPC分类号： G06K9/00
CPC分类号： B41J2/2142 , G06T7/001 , G06T2207/30144 , H01J49/165
摘要： An automated method of evaluating an electrospray jet includes: capturing image information about the electrospray jet, enhancing the image information to provide a clearer image when needed, comparing the captured image information, and generating a signal to indicative of the electrospray jet operation. The signal may be used to automatically adjust the electrospray.
摘要翻译： 评估电喷雾射流的自动化方法包括：捕获关于电喷雾射流的图像信息，增强图像信息以在需要时提供更清晰的图像，比较所捕获的图像信息，以及生成指示电喷射射流操作的信号。 该信号可用于自动调节电喷雾。
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4.发明授权公开(公告)号：US07723678B2
公开(公告)日：2010-05-25
申请号：US11398305
申请日：2006-04-04
申请人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
发明人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
IPC分类号： H01J49/14
CPC分类号： H01J49/142
摘要： An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
摘要翻译： 一种用于从样品中产生分析物离子的装置和方法。 提供一种离子产生装置，其具有具有出口的腔室和具有材料的表面，以及用于将高速气流经由腔室朝向出口施加的装置，使得通过高速气体和材料之间的物理相互作用产生带电粒子 。 带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。 主要离子从离子产生装置的出口朝向样品承载表面发射，分析物离子通过主离子冲击表面上的分析物样品而产生。
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公开(公告)号：US07262841B2
公开(公告)日：2007-08-28
申请号：US11083236
申请日：2005-03-17
IPC分类号： G01B11/26
CPC分类号： G01B11/27 , H01J49/0418 , H01J49/164
摘要： An apparatus and method for aligning a laser beam in an ion source. A mounting member has a first end, a second end, and an axis. An awl is positioned on the axis and operably connected to the first end. A biasing member is arranged to urge the awl along the axis when the apparatus is mounted on the ion source to create a mark for aligning the laser beam.
摘要翻译： 用于对准离子源中的激光束的装置和方法。 安装构件具有第一端，第二端和轴。 锥体位于轴上并且可操作地连接到第一端。 偏置构件布置成当装置安装在离子源上时沿着轴推动锥形以产生用于对准激光束的标记。
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公开(公告)号：US20070051899A1
公开(公告)日：2007-03-08
申请号：US11223285
申请日：2005-09-08
申请人： Jean-Luc Truche , Gregor Overney , William Fisher , Richard Tella
发明人： Jean-Luc Truche , Gregor Overney , William Fisher , Richard Tella
CPC分类号： H01J49/0418 , G03B15/07
摘要： The invention provides an apparatus for producing an image of a global surface of an ion source sample plate that is exterior to an ion source. In general terms, the apparatus contains a sample plate for an ion source, an imaging device (e.g., a CCD or CMOS camera) and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate surface. The apparatus may be present at a location that is remote to the ion source.
摘要翻译： 本发明提供了一种用于产生离子源外部的离子源样品板的全局表面的图像的装置。 通常，该装置包含用于离子源的样品板，成像装置（例如，CCD或CMOS照相机）和照明装置，其被配置为产生接触样品板表面以限定掠入角的光束 在光束和样品板表面之间。 该装置可以存在于远离离子源的位置处。
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公开(公告)号：US20060278824A1
公开(公告)日：2006-12-14
申请号：US11148786
申请日：2005-06-08
申请人： Jean-Luc Truche , Gregor Overney , William Fisher , Richard Tella
发明人： Jean-Luc Truche , Gregor Overney , William Fisher , Richard Tella
IPC分类号： H01J49/16
CPC分类号： H01J49/0418 , G03B15/07 , H01J49/0004
摘要： The invention provides a mass spectrometry system ion source containing a sample plate and an illumination device that is configured to produce a light beam that contacts the sample plate surface to define a grazing angle between the light beam and the sample plate surface. The ion source may also contain an imaging device, e.g., a CCD or CMOS camera or the like, for viewing the area. In one embodiment, the imaging device may be connected to a display, e.g., a video monitor. Methods and mass spectrometry systems empliying the ion source are also provided.
摘要翻译： 本发明提供一种包含样品板和照明装置的质谱系统离子源，其被配置为产生与样品板表面接触以限定光束和样品板表面之间的掠射角的光束。 离子源还可以包含用于观察该区域的成像装置，例如CCD或CMOS照相机等。 在一个实施例中，成像装置可以连接到显示器，例如视频监视器。 还提供了使用离子源的方法和质谱系统。
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公开(公告)号：US07132670B2
公开(公告)日：2006-11-07
申请号：US11015190
申请日：2004-12-16
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.
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公开(公告)号：US07115860B2
公开(公告)日：2006-10-03
申请号：US11065516
申请日：2005-02-23
申请人： Paul C. Goodley , Jean-Luc Truche
发明人： Paul C. Goodley , Jean-Luc Truche
CPC分类号： H01J49/167 , H01J49/0018 , H01J49/04
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid, a manifold having a plurality of nozzles, a conduit connecting the reservoir to the manifold and a counter electrode having a potential different between the counter electrode and the nozzles to enable liquid to be ejected from the nozzles in droplets and to enable ions to be ejected from the droplets.
摘要翻译： 用于分析器的离子源包括用于容纳液体的储存器，具有多个喷嘴的歧管，将储存器连接到歧管的导管和在对电极和喷嘴之间具有不同电位的对电极， 从喷嘴喷出液滴，并使离子从液滴中喷出。
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公开(公告)号：US20050274905A1
公开(公告)日：2005-12-15
申请号：US11155070
申请日：2005-06-16
申请人： Timothy Joyce , Jean-Luc Truche , Jian Bai
发明人： Timothy Joyce , Jean-Luc Truche , Jian Bai
CPC分类号： H01J49/164 , H01J49/0422 , H01J49/0477 , H01J49/0486
摘要： The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.
摘要翻译： 本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。 离子源还可以包括温度传感器。 加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。 还公开了具有基于基质的离子源的质谱仪系统。 还提供了使用被加热到预定温度的气体产生离子的方法。
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