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公开(公告)号：US20080032995A1
公开(公告)日：2008-02-07
申请号：US11829836
申请日：2007-07-27
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
IPC分类号： A61K31/352 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/496 , A61P25/30 , C07D311/04 , C07D405/02 , C07D413/02 , C07D417/02
CPC分类号： C07D413/12 , C07D311/36 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译： 公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。
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公开(公告)号：US20080207610A1
公开(公告)日：2008-08-28
申请号：US12019034
申请日：2008-01-24
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
IPC分类号： A61K31/5377 , C07D311/22 , A61K31/352 , A61P25/30 , C07D413/12 , A61K31/4245
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译： 公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。
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公开(公告)号：US08158810B2
公开(公告)日：2012-04-17
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/35 , C07D307/77
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译： 公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。
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公开(公告)号：US20090209533A1
公开(公告)日：2009-08-20
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/352 , C07D417/12 , C07D413/12 , C07D311/22 , A61K31/427 , A61K31/4245 , A61K31/5377 , A61P25/30
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译： 公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。
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公开(公告)号：US20100113449A1
公开(公告)日：2010-05-06
申请号：US12607833
申请日：2009-10-28
申请人： Matthew Abelman , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Xiaofen Li , Thao Perry , Jeff Zablocki
发明人： Matthew Abelman , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Xiaofen Li , Thao Perry , Jeff Zablocki
IPC分类号： A61K31/18 , A61K31/5375 , A61K31/4406 , A61K31/41 , A61K31/24 , A61K31/196 , C07D295/12 , C07D213/59 , C07D257/04 , C07C311/14 , C07C311/09 , A61P25/00 , A61P9/00 , A61P3/10
CPC分类号： C07C311/08 , C07C311/14 , C07C311/29 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07D213/38 , C07D213/59 , C07D213/82 , C07D257/04 , C07D295/12 , C07D295/13 , C07F9/4021
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (IA) or (IB): as further described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式（IA）或（IB）给出：如本文进一步描述的。 本发明还涉及制备化合物的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US08389500B2
公开(公告)日：2013-03-05
申请号：US12607833
申请日：2009-10-28
申请人： Matthew Abelman , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Xiaofen Li , Thao Perry , Jeff Zablocki
发明人： Matthew Abelman , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Xiaofen Li , Thao Perry , Jeff Zablocki
IPC分类号： A61K31/18 , A61K31/196 , A61K31/24 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K31/662 , A61P3/10 , A61P9/00 , A61P25/02 , A61P25/08 , C07C311/08 , C07C311/14 , C07D213/42 , C07D213/82 , C07D257/04 , C07D295/13 , C07F9/40
CPC分类号： C07C311/08 , C07C311/14 , C07C311/29 , C07C317/32 , C07C2601/02 , C07C2601/08 , C07D213/38 , C07D213/59 , C07D213/82 , C07D257/04 , C07D295/12 , C07D295/13 , C07F9/4021
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (IA) or (IB): as further described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式（IA）或（IB）给出：如本文进一步描述的。 本发明还涉及制备化合物的方法以及含有这些化合物的药物组合物。
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公开(公告)号：US09371329B2
公开(公告)日：2016-06-21
申请号：US14274422
申请日：2014-05-09
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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公开(公告)号：US20140303158A1
公开(公告)日：2014-10-09
申请号：US14274422
申请日：2014-05-09
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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公开(公告)号：US08952034B2
公开(公告)日：2015-02-10
申请号：US12843702
申请日：2010-07-26
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： A01N43/42 , A61K31/44 , C07D491/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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公开(公告)号：US20110021521A1
公开(公告)日：2011-01-27
申请号：US12843702
申请日：2010-07-26
申请人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
发明人： Britton Corkey , Elfatih Elzein , Robert Jiang , Rao Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Gregory Notte , Eric Parkhill , Thao Perry , Jeff Zablocki
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/5025 , A61K31/519 , C07D413/14 , C07D403/14 , A61K31/501 , A61P25/08 , A61P29/00 , A61P9/00 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及钠通道抑制剂及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的化合物。 在具体实施方案中，化合物的结构由式I给出：其中W1，W2，W3，R1，Q，X1，X2和X3如本文所述，用于制备和使用化合物和药物组合物的方法 含有相同的
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